Construction of PIK3C3 Transgenic Pig and Its Pathogenesis of Liver Damage

Construction of PIK3C3 Transgenic Pig and Its Pathogenesis of Liver Damage

As a member of the PIKs family, PIK3C3 participates in autophagy and plays a central role in liver function. Several studies demonstrated that the complete suppression of PIK3C3 in mammals can cause hepatomegaly and hepatosteatosis. However, the function of PIK3C3 overexpression on the liver and oth...

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Bibliographic Details
Main Authors: Jing Wang, Sami Ullah Khan, Pan Cao, Xi Chen, Fengchong Wang, Di Zou, Honghui Li, Heng Zhao, Kaixiang Xu, Deling Jiao, Chang Yang, Feiyan Zhu, Yaxuan Zhang, Yanhua Su, Wenmin Cheng, Baoyu Jia, Yubo Qing, Muhammad Ameen Jamal, Hong-Ye Zhao, Hong-Jiang Wei
Format: Article
Language:English
Published: MDPI AG 2022-04-01
Series:Life
Subjects:
PIK3C3
transgenic pigs
liver damage
autophagy
Online Access:https://www.mdpi.com/2075-1729/12/5/630

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