PERFORMANCE ANALYSIS OF FITTED CURVES FOR STEADY-STATE (IN)ACTIVATION OF IONIC CURRENTS PRESENT IN PURKINJE CELL SOMATA ON SOMATIC MEMBRANE POTENTIAL
In this study sigmoid-shaped curves are fitted for steady-state activation and inactivation data of ionic currents which are defined in literature to be present in Purkinje cell somata. Marquardt-Levenberg nonlinear least-square parameter estimation algorithm is used for curve fitting. Then a somati...
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| Format: | Article |
| Language: | English |
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Pamukkale University
2002-01-01
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| Series: | Pamukkale University Journal of Engineering Sciences |
| Subjects: | |
| Online Access: | http://dergipark.ulakbim.gov.tr/pajes/article/view/5000089788 |
| _version_ | 1797905533358833664 |
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| author | Mahmut ÖZER Temel KAYIKÇIOĞLU |
| author_facet | Mahmut ÖZER Temel KAYIKÇIOĞLU |
| author_sort | Mahmut ÖZER |
| collection | DOAJ |
| description | In this study sigmoid-shaped curves are fitted for steady-state activation and inactivation data of ionic currents which are defined in literature to be present in Purkinje cell somata. Marquardt-Levenberg nonlinear least-square parameter estimation algorithm is used for curve fitting. Then a somatic compartmental model of Purkinje cell is constructed, and somatic membrane potentials are calculated for several different current injection cases. It's shown that means and standard deviations of differences between somatic membrane potentials which are calculated with fitted curves and original equations separately are so small. |
| first_indexed | 2024-04-10T10:06:48Z |
| format | Article |
| id | doaj.art-80f92f0df4eb48bbaea306b9b7857895 |
| institution | Directory Open Access Journal |
| issn | 1300-7009 2147-5881 |
| language | English |
| last_indexed | 2024-04-10T10:06:48Z |
| publishDate | 2002-01-01 |
| publisher | Pamukkale University |
| record_format | Article |
| series | Pamukkale University Journal of Engineering Sciences |
| spelling | doaj.art-80f92f0df4eb48bbaea306b9b78578952023-02-15T16:22:24ZengPamukkale UniversityPamukkale University Journal of Engineering Sciences1300-70092147-58812002-01-018179845000083856PERFORMANCE ANALYSIS OF FITTED CURVES FOR STEADY-STATE (IN)ACTIVATION OF IONIC CURRENTS PRESENT IN PURKINJE CELL SOMATA ON SOMATIC MEMBRANE POTENTIALMahmut ÖZERTemel KAYIKÇIOĞLUIn this study sigmoid-shaped curves are fitted for steady-state activation and inactivation data of ionic currents which are defined in literature to be present in Purkinje cell somata. Marquardt-Levenberg nonlinear least-square parameter estimation algorithm is used for curve fitting. Then a somatic compartmental model of Purkinje cell is constructed, and somatic membrane potentials are calculated for several different current injection cases. It's shown that means and standard deviations of differences between somatic membrane potentials which are calculated with fitted curves and original equations separately are so small.http://dergipark.ulakbim.gov.tr/pajes/article/view/5000089788Purkinje hücresi, Soma, Membran, Aktivasyon, Inaktivasyon |
| spellingShingle | Mahmut ÖZER Temel KAYIKÇIOĞLU PERFORMANCE ANALYSIS OF FITTED CURVES FOR STEADY-STATE (IN)ACTIVATION OF IONIC CURRENTS PRESENT IN PURKINJE CELL SOMATA ON SOMATIC MEMBRANE POTENTIAL Pamukkale University Journal of Engineering Sciences Purkinje hücresi, Soma, Membran, Aktivasyon, Inaktivasyon |
| title | PERFORMANCE ANALYSIS OF FITTED CURVES FOR STEADY-STATE (IN)ACTIVATION OF IONIC CURRENTS PRESENT IN PURKINJE CELL SOMATA ON SOMATIC MEMBRANE POTENTIAL |
| title_full | PERFORMANCE ANALYSIS OF FITTED CURVES FOR STEADY-STATE (IN)ACTIVATION OF IONIC CURRENTS PRESENT IN PURKINJE CELL SOMATA ON SOMATIC MEMBRANE POTENTIAL |
| title_fullStr | PERFORMANCE ANALYSIS OF FITTED CURVES FOR STEADY-STATE (IN)ACTIVATION OF IONIC CURRENTS PRESENT IN PURKINJE CELL SOMATA ON SOMATIC MEMBRANE POTENTIAL |
| title_full_unstemmed | PERFORMANCE ANALYSIS OF FITTED CURVES FOR STEADY-STATE (IN)ACTIVATION OF IONIC CURRENTS PRESENT IN PURKINJE CELL SOMATA ON SOMATIC MEMBRANE POTENTIAL |
| title_short | PERFORMANCE ANALYSIS OF FITTED CURVES FOR STEADY-STATE (IN)ACTIVATION OF IONIC CURRENTS PRESENT IN PURKINJE CELL SOMATA ON SOMATIC MEMBRANE POTENTIAL |
| title_sort | performance analysis of fitted curves for steady state in activation of ionic currents present in purkinje cell somata on somatic membrane potential |
| topic | Purkinje hücresi, Soma, Membran, Aktivasyon, Inaktivasyon |
| url | http://dergipark.ulakbim.gov.tr/pajes/article/view/5000089788 |
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