Associations of anxiety and depression with restless leg syndrome: a systematic review and meta-analysis
BackgroundThe levels of anxiety and depression among patients with restless leg syndrome (RLS) are controversial. The aim of this systematic review and meta-analysis was to compare the levels of depression and anxiety among individuals with RLS with those of healthy controls.MethodsWe conducted an e...
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Frontiers Media S.A.
2024-03-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2024.1366839/full |
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| author | Tianyang An Haiyang Sun Lu Yuan Xiuling Wu Baoquan Lu |
| author_facet | Tianyang An Haiyang Sun Lu Yuan Xiuling Wu Baoquan Lu |
| author_sort | Tianyang An |
| collection | DOAJ |
| description | BackgroundThe levels of anxiety and depression among patients with restless leg syndrome (RLS) are controversial. The aim of this systematic review and meta-analysis was to compare the levels of depression and anxiety among individuals with RLS with those of healthy controls.MethodsWe conducted an extensive electronic search of the PubMed, Web of Science, EMBASE, and Cochrane Library databases from their inception dates to 20 June 2023. Studies presenting data on depression and anxiety in individuals with RLS were included, and a comprehensive meta-analysis was performed.ResultsTwenty-one studies matched the inclusion criteria. Significantly more depressive symptoms were present in the individuals with RLS than in those without RLS, as measured by the Beck Depression Inventory [mean difference (MD) = 6.58, 95% confidence interval (CI) = 5.54–7.62, p < 0.01; heterogeneity I2 = 0%, p = 0.99]. Similarly, the results from the Beck Anxiety Inventory indicated that there were significantly more pronounced anxiety symptoms in the individuals with RLS than in those without RLS (MD = 9.30, 95%CI = 7.65–10.94, p < 0.01; heterogeneity I2 = 0%, p = 0.92). The other anxiety and depression scales also yielded statistically significant results. Significant heterogeneity was observed in the Hamilton Depression Rating Scale and Hamilton Anxiety Rating Scale, with the primary contributing factor probably being the scoring criteria of the scales.ConclusionThis meta-analysis found that the levels of depression and anxiety symptoms were significantly higher in individuals with RLS than in their healthy counterparts.Systematic review registration:https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42023410364, (identifier CRD42023410364). |
| first_indexed | 2024-04-24T22:57:10Z |
| format | Article |
| id | doaj.art-80fa27c8adf9484a8138279dcaf56fe4 |
| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-04-24T22:57:10Z |
| publishDate | 2024-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj.art-80fa27c8adf9484a8138279dcaf56fe42024-03-18T04:39:00ZengFrontiers Media S.A.Frontiers in Neurology1664-22952024-03-011510.3389/fneur.2024.13668391366839Associations of anxiety and depression with restless leg syndrome: a systematic review and meta-analysisTianyang An0Haiyang Sun1Lu Yuan2Xiuling Wu3Baoquan Lu4College of Clinical Medicine, North China University of Science and Technology, Tangshan, Hebei, ChinaCangzhou Center for Disease Control and Prevention, Cangzhou, Hebei, ChinaCollege of Psychology and Mental Health of North China University of Science and Technology, Tangshan, Hebei, ChinaDepartment of Neurology, Tangshan Gongren Hospital, Tangshan, Hebei, ChinaDepartment of Neurology, Tangshan Gongren Hospital, Tangshan, Hebei, ChinaBackgroundThe levels of anxiety and depression among patients with restless leg syndrome (RLS) are controversial. The aim of this systematic review and meta-analysis was to compare the levels of depression and anxiety among individuals with RLS with those of healthy controls.MethodsWe conducted an extensive electronic search of the PubMed, Web of Science, EMBASE, and Cochrane Library databases from their inception dates to 20 June 2023. Studies presenting data on depression and anxiety in individuals with RLS were included, and a comprehensive meta-analysis was performed.ResultsTwenty-one studies matched the inclusion criteria. Significantly more depressive symptoms were present in the individuals with RLS than in those without RLS, as measured by the Beck Depression Inventory [mean difference (MD) = 6.58, 95% confidence interval (CI) = 5.54–7.62, p < 0.01; heterogeneity I2 = 0%, p = 0.99]. Similarly, the results from the Beck Anxiety Inventory indicated that there were significantly more pronounced anxiety symptoms in the individuals with RLS than in those without RLS (MD = 9.30, 95%CI = 7.65–10.94, p < 0.01; heterogeneity I2 = 0%, p = 0.92). The other anxiety and depression scales also yielded statistically significant results. Significant heterogeneity was observed in the Hamilton Depression Rating Scale and Hamilton Anxiety Rating Scale, with the primary contributing factor probably being the scoring criteria of the scales.ConclusionThis meta-analysis found that the levels of depression and anxiety symptoms were significantly higher in individuals with RLS than in their healthy counterparts.Systematic review registration:https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42023410364, (identifier CRD42023410364).https://www.frontiersin.org/articles/10.3389/fneur.2024.1366839/fulldepressionanxietyrestless legs syndromemeta-analysismental health |
| spellingShingle | Tianyang An Haiyang Sun Lu Yuan Xiuling Wu Baoquan Lu Associations of anxiety and depression with restless leg syndrome: a systematic review and meta-analysis Frontiers in Neurology depression anxiety restless legs syndrome meta-analysis mental health |
| title | Associations of anxiety and depression with restless leg syndrome: a systematic review and meta-analysis |
| title_full | Associations of anxiety and depression with restless leg syndrome: a systematic review and meta-analysis |
| title_fullStr | Associations of anxiety and depression with restless leg syndrome: a systematic review and meta-analysis |
| title_full_unstemmed | Associations of anxiety and depression with restless leg syndrome: a systematic review and meta-analysis |
| title_short | Associations of anxiety and depression with restless leg syndrome: a systematic review and meta-analysis |
| title_sort | associations of anxiety and depression with restless leg syndrome a systematic review and meta analysis |
| topic | depression anxiety restless legs syndrome meta-analysis mental health |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2024.1366839/full |
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