Dysregulation of the Synaptic Cytoskeleton in the PFC Drives Neural Circuit Pathology, Leading to Social Dysfunction

Dysregulation of the Synaptic Cytoskeleton in the PFC Drives Neural Circuit Pathology, Leading to Social Dysfunction

Summary: Psychiatric disorders are highly heritable pathologies of altered neural circuit functioning. How genetic mutations lead to specific neural circuit abnormalities underlying behavioral disruptions, however, remains unclear. Using circuit-selective transgenic tools and a mouse model of malada...

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Bibliographic Details
Main Authors: Il Hwan Kim, Namsoo Kim, Sunwhi Kim, Koji Toda, Christina M. Catavero, Jamie L. Courtland, Henry H. Yin, Scott H. Soderling
Format: Article
Language:English
Published: Elsevier 2020-07-01
Series:Cell Reports
Subjects:
social behavior
prefrontal cortex
basolateral amygdala
neural circuit
circuit pathology
schizophrenia
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124720309463

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