Transcriptome-module phenotype association study implicates extracellular vesicles biogenesis in Plasmodium falciparum artemisinin resistance

Transcriptome-module phenotype association study implicates extracellular vesicles biogenesis in Plasmodium falciparum artemisinin resistance

Plasmodium falciparum malaria is still an important disease in sub-Saharan Africa (sSA). Great strides have been made in its control spear-headed by artemisinin (ART)-based combination therapies (ACTs). However, concerns about the imminent spread of ART-resistant (ARTr) malaria parasites to sSA thre...

Full description

Bibliographic Details
Main Authors:	Kwesi Z. Tandoh, Oheneba C. Hagan, Michael D. Wilson, Neils B. Quashie, Nancy O. Duah-Quashie
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2022-08-01
Series:	Frontiers in Cellular and Infection Microbiology
Subjects:	transcriptomics modules association artemisinin resistance Plasmodium falciparum extracellular vesicles
Online Access:	https://www.frontiersin.org/articles/10.3389/fcimb.2022.886728/full

Similar Items

Assessment of artemisinin tolerance in Plasmodium falciparum clinical isolates in children with uncomplicated malaria in Ghana
by: Samuel Yao Ahorhorlu, et al.
Published: (2023-02-01)

Putative molecular markers of Plasmodium falciparum resistance to antimalarial drugs in malaria parasites from Ghana
by: Sena Adzoa Matrevi, et al.
Published: (2024-02-01)

Plasmodium falciparum rosetting protects schizonts against artemisinin
by: Lee, Wenn-Chyau, et al.
Published: (2022)

No Plasmodium falciparum Chloroquine Resistance Transporter and Artemisinin Resistance Mutations, Haiti
by: Jeanne P. Vincent, et al.
Published: (2018-11-01)

Induction of Multidrug Tolerance in Plasmodium falciparum by Extended Artemisinin Pressure
by: Sandie Ménard, et al.
Published: (2015-10-01)

Plasmodium falciparum resistance to artemisinin-based combination therapies: A sword of Damocles in the path toward malaria elimination
by: Ouji Manel, et al.
Published: (2018-01-01)

Differential infectivity of gametocytes after artemisinin-based combination therapy of uncomplicated falciparum malaria
by: Dinkorma T. Ouologuem, et al.
Published: (2018-12-01)

Lack of artemisinin resistance in Plasmodium falciparum in northwest Benin after 10 years of use of artemisinin-based combination therapy
by: Ogouyèmi-Hounto Aurore, et al.
Published: (2016-01-01)

Polymorphisms of the artemisinin resistant marker (K13) in Plasmodium falciparum parasite populations of Grande Comore Island 10 years after artemisinin combination therapy
by: Bo Huang, et al.
Published: (2015-12-01)

Mutation in the 26S proteasome regulatory subunit rpn2 gene in Plasmodium falciparum confers resistance to artemisinin
by: Adriana F. Gonçalves, et al.
Published: (2024-02-01)

Artemisinin-Naphthoquine Combination (ARCO®): An Overview of the Progress
by: Qingyun Huang, et al.
Published: (2010-12-01)

Artemisinin resistance in <it>Plasmodium falciparum </it>is associated with an altered temporal pattern of transcription
by: Newton Paul N, et al.
Published: (2011-08-01)

Ring stage dormancy of Plasmodium falciparum tolerant to artemisinin and its analogues – A genetically regulated “Sleeping Beauty”
by: Saranya Auparakkitanon, et al.
Published: (2023-04-01)

Molecular surveillance of Kelch 13 polymorphisms in Plasmodium falciparum isolates from Kenya and Ethiopia
by: Brook Jeang, et al.
Published: (2024-01-01)

Plasmodium falciparum sexual conversion rates can be affected by artemisinin-based treatment in naturally infected malaria patients
by: Harvie P. Portugaliza, et al.
Published: (2022-09-01)

Plasmodium falciparum K13 mutations in Africa and Asia impact artemisinin resistance and parasite fitness
by: Barbara H Stokes, et al.
Published: (2021-07-01)

Molecular detection of drug-resistant Plasmodium falciparum mutants in Assam
by: Lipika Barman, et al.
Published: (2023-01-01)

Naturally Acquired Kelch13 Mutations in Plasmodium falciparum Strains Modulate In Vitro Ring-Stage Artemisinin-Based Drug Tolerance and Parasite Survival in Response to Hyperoxia
by: Sandra Duffy, et al.
Published: (2022-10-01)

Genomic epidemiology of artemisinin resistant malaria
by: MalariaGEN Plasmodium falciparum Community Project
Published: (2016-03-01)

An autophagy-related single nucleotide polymorphism in artemisinin-resistant Plasmodium falciparum
by: Breglio, K
Published: (2018)

Widespread Availability of Artemisinin Monotherapy in the United States
by: Robert M. Rakita, et al.
Published: (2011-05-01)

tRNA modification reprogramming contributes to artemisinin resistance in Plasmodium falciparum
by: Small-Saunders, Jennifer L., et al.
Published: (2024)

Comparative effect of artemether-lumefantrine and artesunate-amodiaquine on gametocyte clearance in children with uncomplicated Plasmodium falciparum malaria in Madagascar
by: Malalanandrianina A. Rakotoarisoa, et al.
Published: (2022-11-01)

New insights into the spread of resistance to artemisinin and its analogues
by: Noreen Noreen, et al.
Published: (2021-12-01)

Effectiveness of artemether–lumefantrine for treating uncomplicated malaria in low- and high-transmission areas of Ghana
by: Mawusi Adepa Mawuli, et al.
Published: (2024-02-01)

Detection of novel Plasmodium falciparum coronin gene mutations in a recrudescent ACT-treated patient in South-Western Nigeria
by: Olusola Ajibaye, et al.
Published: (2024-04-01)

Investigation and Evaluation of Genetic Diversity of Plasmodium falciparum Kelch 13 Polymorphisms Imported From Southeast Asia and Africa in Southern China
by: Jun Feng, et al.
Published: (2019-04-01)

Artemisinin Binds and Inhibits the Activity of <i>Plasmodium falciparum</i> Ddi1, a Retroviral Aspartyl Protease
by: Noah Machuki Onchieku, et al.
Published: (2021-11-01)

Evolution of Plasmodium falciparum antimalarial drug resistance markers post-adoption of artemisinin-based combination therapies in Yaounde, Cameroon
by: Peter Thelma Ngwa Niba, et al.
Published: (2023-07-01)

Evidence of an increased incidence of day 3 parasitaemia in Suriname: an indicator of the emerging resistance of Plasmodium falciparum to artemether
by: Stephen GS Vreden, et al.
Published: (2013-12-01)

Plasmodium falciparum kelch13 polymorphisms identified after treatment failure with artemisinin-based combination therapy in Niger
by: Ibrahima Issa Arzika, et al.
Published: (2023-05-01)

Differential Effect of Extracellular Vesicles Derived from <i>Plasmodium falciparum</i>-Infected Red Blood Cells on Monocyte Polarization
by: Ladawan Khowawisetsut, et al.
Published: (2023-01-01)

Synergistic interaction of two antimalarial drugs, artemisinin and concanamycin A
by: Nurul Izzaty Najwa Zahari, et al.
Published: (2023-06-01)

Syk Kinase Inhibitors Synergize with Artemisinins by Enhancing Oxidative Stress in <i>Plasmodium falciparum</i>-Parasitized Erythrocytes
by: Ioannis Tsamesidis, et al.
Published: (2020-08-01)

Imported severe Plasmodium falciparum infection in the first trimester of pregnancy complicated by post-artemisinin delayed hemolysis and intrauterine fetal death, a case report
by: Kohei Kamegai, et al.
Published: (2023-05-01)

Impact of parasite genomic dynamics on the sensitivity of Plasmodium falciparum isolates to piperaquine and other antimalarial drugs
by: Dancan M. Wakoli, et al.
Published: (2022-11-01)

The search for molecular mimicry in proteins carried by extracellular vesicles secreted by cells infected with Plasmodium falciparum
by: Vinicio Armijos-Jaramillo, et al.
Published: (2021-01-01)

Extracellular Vesicles Derived from Early and Late Stage <i>Plasmodium falciparum</i>-Infected Red Blood Cells Contain Invasion-Associated Proteins
by: Sinmanus Vimonpatranon, et al.
Published: (2022-07-01)

Chemoresistance of Plasmodium falciparum and Plasmodium vivax parasites in Brazil: consequences on disease morbidity and control
by: Bianca Ervatti Gama, et al.
Published: (2011-08-01)

Assessment of Plasmodium falciparum drug resistance associated molecular markers in Mandla, Madhya Pradesh, India
by: Akansha Singh, et al.
Published: (2023-12-01)