The Occurrence of Genetic Recombination between Viruses and Human, it's Possible Influence on Vaccination
Relevance. The genetic recombination between viruses and men is known long ago. It can be divided on relict and ontogenic ones. For the host the recombination may display different consequences the nature of which is not exposed explicitly.Aim is to analyze (on the base of computer comparison of the...
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| Format: | Article |
| Language: | Russian |
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Numikom LLC
2020-01-01
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| Series: | Эпидемиология и вакцинопрофилактика |
| Subjects: | |
| Online Access: | https://www.epidemvac.ru/jour/article/view/859 |
| _version_ | 1826567476297596928 |
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| author | E. P. Kharchenko |
| author_facet | E. P. Kharchenko |
| author_sort | E. P. Kharchenko |
| collection | DOAJ |
| description | Relevance. The genetic recombination between viruses and men is known long ago. It can be divided on relict and ontogenic ones. For the host the recombination may display different consequences the nature of which is not exposed explicitly.Aim is to analyze (on the base of computer comparison of the primary structure of viral and human proteins ) the occurrence of twodirectional recombination by small genome fragments between viruses and men and describe its possible after-effects.Materials and methods. For this computer study human and virus protein sequences were used from data bases available in INTERNET.Results. It was indicated that recombination (cryptical and explicit) by small genome fragments between viruses and men occurred many times in the past and many viruses pathogenic for men were involved in it.Conclusion. The bioinformatics approach allows to look at the past of viruses and men and find the traces of genetic information changes between them that may predetermine the effects of vaccines and diagnostic immune tests. |
| first_indexed | 2024-04-10T02:50:01Z |
| format | Article |
| id | doaj.art-80fed61bec0645fabd1d5abf7c07acf4 |
| institution | Directory Open Access Journal |
| issn | 2073-3046 2619-0494 |
| language | Russian |
| last_indexed | 2025-03-14T11:08:09Z |
| publishDate | 2020-01-01 |
| publisher | Numikom LLC |
| record_format | Article |
| series | Эпидемиология и вакцинопрофилактика |
| spelling | doaj.art-80fed61bec0645fabd1d5abf7c07acf42025-03-02T10:40:31ZrusNumikom LLCЭпидемиология и вакцинопрофилактика2073-30462619-04942020-01-0118641410.31631/2073-3046-2019-18-4-14587The Occurrence of Genetic Recombination between Viruses and Human, it's Possible Influence on VaccinationE. P. Kharchenko0Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of SciencesRelevance. The genetic recombination between viruses and men is known long ago. It can be divided on relict and ontogenic ones. For the host the recombination may display different consequences the nature of which is not exposed explicitly.Aim is to analyze (on the base of computer comparison of the primary structure of viral and human proteins ) the occurrence of twodirectional recombination by small genome fragments between viruses and men and describe its possible after-effects.Materials and methods. For this computer study human and virus protein sequences were used from data bases available in INTERNET.Results. It was indicated that recombination (cryptical and explicit) by small genome fragments between viruses and men occurred many times in the past and many viruses pathogenic for men were involved in it.Conclusion. The bioinformatics approach allows to look at the past of viruses and men and find the traces of genetic information changes between them that may predetermine the effects of vaccines and diagnostic immune tests.https://www.epidemvac.ru/jour/article/view/859recombinationviruseshumanproteinscomputer analysisvaccines |
| spellingShingle | E. P. Kharchenko The Occurrence of Genetic Recombination between Viruses and Human, it's Possible Influence on Vaccination Эпидемиология и вакцинопрофилактика recombination viruses human proteins computer analysis vaccines |
| title | The Occurrence of Genetic Recombination between Viruses and Human, it's Possible Influence on Vaccination |
| title_full | The Occurrence of Genetic Recombination between Viruses and Human, it's Possible Influence on Vaccination |
| title_fullStr | The Occurrence of Genetic Recombination between Viruses and Human, it's Possible Influence on Vaccination |
| title_full_unstemmed | The Occurrence of Genetic Recombination between Viruses and Human, it's Possible Influence on Vaccination |
| title_short | The Occurrence of Genetic Recombination between Viruses and Human, it's Possible Influence on Vaccination |
| title_sort | occurrence of genetic recombination between viruses and human it s possible influence on vaccination |
| topic | recombination viruses human proteins computer analysis vaccines |
| url | https://www.epidemvac.ru/jour/article/view/859 |
| work_keys_str_mv | AT epkharchenko theoccurrenceofgeneticrecombinationbetweenvirusesandhumanitspossibleinfluenceonvaccination AT epkharchenko occurrenceofgeneticrecombinationbetweenvirusesandhumanitspossibleinfluenceonvaccination |