ChemSkin Reference Chemical Database for the Development of an In Vitro Skin Irritation Test
Since the animal test ban on cosmetics in the EU in 2013, alternative in vitro safety tests have been actively researched to replace in vivo animal tests. For the development and evaluation of a new test method, reference chemicals with quality in vivo data are essential to assess the predictive cap...
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| Materiálatiipa: | Artihkal |
| Giella: | English |
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MDPI AG
2021-11-01
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| Ráidu: | Toxics |
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| Liŋkkat: | https://www.mdpi.com/2305-6304/9/11/314 |
| _version_ | 1827675306631102464 |
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| author | Juhee Han Ga-Young Lee Green Bae Mi-Jeong Kang Kyung-Min Lim |
| author_facet | Juhee Han Ga-Young Lee Green Bae Mi-Jeong Kang Kyung-Min Lim |
| author_sort | Juhee Han |
| collection | DOAJ |
| description | Since the animal test ban on cosmetics in the EU in 2013, alternative in vitro safety tests have been actively researched to replace in vivo animal tests. For the development and evaluation of a new test method, reference chemicals with quality in vivo data are essential to assess the predictive capacity and applicability domain. Here, we compiled a reference chemical database (ChemSkin DB) for the development and evaluation of new in vitro skin irritation tests. The first candidates were selected from 317 chemicals (source data <i>n</i> = 1567) searched from the literature from the last 20 years, including previous validation study reports, ECETOC, and published papers. Chemicals showing inconsistent classification or those that were commercially unavailable, difficult or dangerous to handle, prohibitively expensive, or without quality in vivo or in vitro data were removed, leaving a total of 100 chemicals. Supporting references, in vivo Draize scores, UN GHS/EU CLP classifications and commercial sources were compiled. Test results produced by the approved methods of OECD Test No. 439 were included and compared using the classification table, scatter plot, and Pearson correlation analysis to identify the false predictions and differences between in vitro skin irritation tests. These results may provide an insight into the future development of new in vitro skin irritation tests. |
| first_indexed | 2024-03-10T05:01:15Z |
| format | Article |
| id | doaj.art-80ffed2e6910469e901b732192c510be |
| institution | Directory Open Access Journal |
| issn | 2305-6304 |
| language | English |
| last_indexed | 2024-03-10T05:01:15Z |
| publishDate | 2021-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Toxics |
| spelling | doaj.art-80ffed2e6910469e901b732192c510be2023-11-23T01:48:13ZengMDPI AGToxics2305-63042021-11-0191131410.3390/toxics9110314ChemSkin Reference Chemical Database for the Development of an In Vitro Skin Irritation TestJuhee Han0Ga-Young Lee1Green Bae2Mi-Jeong Kang3Kyung-Min Lim4College of Pharmacy, Ewha Womans University, Seoul 03760, KoreaCollege of Pharmacy, Ewha Womans University, Seoul 03760, KoreaCollege of Pharmacy, Ewha Womans University, Seoul 03760, KoreaKorea Water Resources Environment Institute, Gyeongsan 38650, KoreaCollege of Pharmacy, Ewha Womans University, Seoul 03760, KoreaSince the animal test ban on cosmetics in the EU in 2013, alternative in vitro safety tests have been actively researched to replace in vivo animal tests. For the development and evaluation of a new test method, reference chemicals with quality in vivo data are essential to assess the predictive capacity and applicability domain. Here, we compiled a reference chemical database (ChemSkin DB) for the development and evaluation of new in vitro skin irritation tests. The first candidates were selected from 317 chemicals (source data <i>n</i> = 1567) searched from the literature from the last 20 years, including previous validation study reports, ECETOC, and published papers. Chemicals showing inconsistent classification or those that were commercially unavailable, difficult or dangerous to handle, prohibitively expensive, or without quality in vivo or in vitro data were removed, leaving a total of 100 chemicals. Supporting references, in vivo Draize scores, UN GHS/EU CLP classifications and commercial sources were compiled. Test results produced by the approved methods of OECD Test No. 439 were included and compared using the classification table, scatter plot, and Pearson correlation analysis to identify the false predictions and differences between in vitro skin irritation tests. These results may provide an insight into the future development of new in vitro skin irritation tests.https://www.mdpi.com/2305-6304/9/11/314skin irritation testreference chemicalalternative test methodchemical database |
| spellingShingle | Juhee Han Ga-Young Lee Green Bae Mi-Jeong Kang Kyung-Min Lim ChemSkin Reference Chemical Database for the Development of an In Vitro Skin Irritation Test Toxics skin irritation test reference chemical alternative test method chemical database |
| title | ChemSkin Reference Chemical Database for the Development of an In Vitro Skin Irritation Test |
| title_full | ChemSkin Reference Chemical Database for the Development of an In Vitro Skin Irritation Test |
| title_fullStr | ChemSkin Reference Chemical Database for the Development of an In Vitro Skin Irritation Test |
| title_full_unstemmed | ChemSkin Reference Chemical Database for the Development of an In Vitro Skin Irritation Test |
| title_short | ChemSkin Reference Chemical Database for the Development of an In Vitro Skin Irritation Test |
| title_sort | chemskin reference chemical database for the development of an in vitro skin irritation test |
| topic | skin irritation test reference chemical alternative test method chemical database |
| url | https://www.mdpi.com/2305-6304/9/11/314 |
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