MNAT1 promotes proliferation and the chemo-resistance of osteosarcoma cell to cisplatin through regulating PI3K/Akt/mTOR pathway

MNAT1 promotes proliferation and the chemo-resistance of osteosarcoma cell to cisplatin through regulating PI3K/Akt/mTOR pathway

Abstract Background MNAT1 (menage a trois 1, MAT1), a cyclin-dependent kinase-activating kinase (CAK) complex, highly expressed in diverse cancers and was involved in cancer molecular pathogenesis. However, its deliverance profile and biological function in osteosarcoma (OS) remain unclear. Methods...

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Bibliographic Details
Main Authors: Chensheng Qiu, Weiliang Su, Nana Shen, Xiaoying Qi, Xiaolin Wu, Kai Wang, Lin Li, Zhu Guo, Hao Tao, Guanrong Wang, Bohua Chen, Hongfei Xiang
Format: Article
Language:English
Published: BMC 2020-12-01
Series:BMC Cancer
Subjects:
Osteosarcoma
MNAT1
Cisplatin
Online Access:https://doi.org/10.1186/s12885-020-07687-3

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