Genetic Landscape and Emerging Therapies in Uveal Melanoma
Despite successful treatment of primary uveal melanoma, up to 50% of patients will develop systemic metastasis. Metastatic disease portends a poor outcome, and no adjuvant or metastatic therapy has been FDA approved. The genetic landscape of uveal melanoma is unique, providing prognostic and potenti...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-11-01
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| Series: | Cancers |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6694/13/21/5503 |
| _version_ | 1797512716248678400 |
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| author | Rino S. Seedor Marlana Orloff Takami Sato |
| author_facet | Rino S. Seedor Marlana Orloff Takami Sato |
| author_sort | Rino S. Seedor |
| collection | DOAJ |
| description | Despite successful treatment of primary uveal melanoma, up to 50% of patients will develop systemic metastasis. Metastatic disease portends a poor outcome, and no adjuvant or metastatic therapy has been FDA approved. The genetic landscape of uveal melanoma is unique, providing prognostic and potentially therapeutic insight. In this review, we discuss our current understanding of the molecular and cytogenetic mutations in uveal melanoma, and the importance of obtaining such information. Most of our knowledge is based on primary uveal melanoma and a better understanding of the mutational landscape in metastatic uveal melanoma is needed. Clinical trials targeting certain mutations such as <i>GNAQ</i>/<i>GNA11</i>, <i>BAP1</i>, and <i>SF3B1</i> are ongoing and promising. We also discuss the role of liquid biopsies in uveal melanoma in this review. |
| first_indexed | 2024-03-10T06:04:42Z |
| format | Article |
| id | doaj.art-8101a6b7c1cd4916b4648fdac49fccaa |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-10T06:04:42Z |
| publishDate | 2021-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-8101a6b7c1cd4916b4648fdac49fccaa2023-11-22T20:36:13ZengMDPI AGCancers2072-66942021-11-011321550310.3390/cancers13215503Genetic Landscape and Emerging Therapies in Uveal MelanomaRino S. Seedor0Marlana Orloff1Takami Sato2Department of Medical Oncology, Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107, USADepartment of Medical Oncology, Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107, USADepartment of Medical Oncology, Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107, USADespite successful treatment of primary uveal melanoma, up to 50% of patients will develop systemic metastasis. Metastatic disease portends a poor outcome, and no adjuvant or metastatic therapy has been FDA approved. The genetic landscape of uveal melanoma is unique, providing prognostic and potentially therapeutic insight. In this review, we discuss our current understanding of the molecular and cytogenetic mutations in uveal melanoma, and the importance of obtaining such information. Most of our knowledge is based on primary uveal melanoma and a better understanding of the mutational landscape in metastatic uveal melanoma is needed. Clinical trials targeting certain mutations such as <i>GNAQ</i>/<i>GNA11</i>, <i>BAP1</i>, and <i>SF3B1</i> are ongoing and promising. We also discuss the role of liquid biopsies in uveal melanoma in this review.https://www.mdpi.com/2072-6694/13/21/5503uveal melanomametastatic uveal melanomagenetic landscapetargeted therapytreatment strategy |
| spellingShingle | Rino S. Seedor Marlana Orloff Takami Sato Genetic Landscape and Emerging Therapies in Uveal Melanoma Cancers uveal melanoma metastatic uveal melanoma genetic landscape targeted therapy treatment strategy |
| title | Genetic Landscape and Emerging Therapies in Uveal Melanoma |
| title_full | Genetic Landscape and Emerging Therapies in Uveal Melanoma |
| title_fullStr | Genetic Landscape and Emerging Therapies in Uveal Melanoma |
| title_full_unstemmed | Genetic Landscape and Emerging Therapies in Uveal Melanoma |
| title_short | Genetic Landscape and Emerging Therapies in Uveal Melanoma |
| title_sort | genetic landscape and emerging therapies in uveal melanoma |
| topic | uveal melanoma metastatic uveal melanoma genetic landscape targeted therapy treatment strategy |
| url | https://www.mdpi.com/2072-6694/13/21/5503 |
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