Loss of the transcriptional repressor Rev-erbα upregulates metabolism and proliferation in cultured mouse embryonic fibroblasts

Loss of the transcriptional repressor Rev-erbα upregulates metabolism and proliferation in cultured mouse embryonic fibroblasts

Abstract The transcriptional repressor Rev-erbα is known to down-regulate fatty acid metabolism and gluconeogenesis gene expression. In animal models, disruption of Rev-erbα results in global changes in exercise performance, oxidative capacity, and blood glucose levels. However, the complete extent...

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Bibliographic Details
Main Authors:	Sean P. Gillis, Hongwei Yao, Salu Rizal, Hajime Maeda, Julia Chang, Phyllis A. Dennery
Format:	Article
Language:	English
Published:	Nature Portfolio 2021-06-01
Series:	Scientific Reports
Online Access:	https://doi.org/10.1038/s41598-021-91516-5

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