Pulmonary aspiration in preschool children with cystic fibrosis
Abstract Pulmonary aspiration of gastric refluxate (PAGR) has been demonstrated in association with pulmonary inflammation in school aged children with Cystic Fibrosis (CF). We sought to determine if similar findings were present in preschool children. Pepsin was measured in Broncho-alveolar lavage...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2018-12-01
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| Series: | Respiratory Research |
| Online Access: | http://link.springer.com/article/10.1186/s12931-018-0954-1 |
| _version_ | 1811269875490881536 |
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| author | D. Clarke I. Gorman F. Ringholz M. McDermott DW. Cox P. Greally B. Linnane P. Mc Nally |
| author_facet | D. Clarke I. Gorman F. Ringholz M. McDermott DW. Cox P. Greally B. Linnane P. Mc Nally |
| author_sort | D. Clarke |
| collection | DOAJ |
| description | Abstract Pulmonary aspiration of gastric refluxate (PAGR) has been demonstrated in association with pulmonary inflammation in school aged children with Cystic Fibrosis (CF). We sought to determine if similar findings were present in preschool children. Pepsin was measured in Broncho-alveolar lavage (BAL) fluid collected from clinically stable preschool children with CF and controls. Elevated pepsin levels were found in a subgroup of children with CF, but this was not found to be associated with pulmonary infection, pulmonary inflammation or respiratory or gastrointestinal symptoms. |
| first_indexed | 2024-04-12T21:49:56Z |
| format | Article |
| id | doaj.art-8104a2f343354ac2afc5b27459050c05 |
| institution | Directory Open Access Journal |
| issn | 1465-993X |
| language | English |
| last_indexed | 2024-04-12T21:49:56Z |
| publishDate | 2018-12-01 |
| publisher | BMC |
| record_format | Article |
| series | Respiratory Research |
| spelling | doaj.art-8104a2f343354ac2afc5b27459050c052022-12-22T03:15:31ZengBMCRespiratory Research1465-993X2018-12-011911310.1186/s12931-018-0954-1Pulmonary aspiration in preschool children with cystic fibrosisD. Clarke0I. Gorman1F. Ringholz2M. McDermott3DW. Cox4P. Greally5B. Linnane6P. Mc Nally7National Children’s Research CentreNational Children’s Research CentreNational Children’s Research CentreOur Lady’s Children’s HospitalNational Children’s Research CentreNational Children’s HospitalNational Children’s Research CentreNational Children’s Research CentreAbstract Pulmonary aspiration of gastric refluxate (PAGR) has been demonstrated in association with pulmonary inflammation in school aged children with Cystic Fibrosis (CF). We sought to determine if similar findings were present in preschool children. Pepsin was measured in Broncho-alveolar lavage (BAL) fluid collected from clinically stable preschool children with CF and controls. Elevated pepsin levels were found in a subgroup of children with CF, but this was not found to be associated with pulmonary infection, pulmonary inflammation or respiratory or gastrointestinal symptoms.http://link.springer.com/article/10.1186/s12931-018-0954-1 |
| spellingShingle | D. Clarke I. Gorman F. Ringholz M. McDermott DW. Cox P. Greally B. Linnane P. Mc Nally Pulmonary aspiration in preschool children with cystic fibrosis Respiratory Research |
| title | Pulmonary aspiration in preschool children with cystic fibrosis |
| title_full | Pulmonary aspiration in preschool children with cystic fibrosis |
| title_fullStr | Pulmonary aspiration in preschool children with cystic fibrosis |
| title_full_unstemmed | Pulmonary aspiration in preschool children with cystic fibrosis |
| title_short | Pulmonary aspiration in preschool children with cystic fibrosis |
| title_sort | pulmonary aspiration in preschool children with cystic fibrosis |
| url | http://link.springer.com/article/10.1186/s12931-018-0954-1 |
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