REM sleep is associated with the volume of the cholinergic basal forebrain in aMCI individuals
Abstract Background Rapid-eye movement (REM) sleep highly depends on the activity of cholinergic basal forebrain (BF) neurons and is reduced in Alzheimer’s disease. Here, we investigated the associations between the volume of BF nuclei and REM sleep characteristics, and the impact of cognitive statu...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-09-01
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| Series: | Alzheimer’s Research & Therapy |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13195-023-01265-y |
| _version_ | 1797453616884219904 |
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| author | Claire André Marie-Ève Martineau-Dussault Véronique Daneault Hélène Blais Sonia Frenette Dominique Lorrain Carol Hudon Célyne Bastien Dominique Petit Alexandre Lafrenière Cynthia Thompson Jacques Montplaisir Nadia Gosselin Julie Carrier |
| author_facet | Claire André Marie-Ève Martineau-Dussault Véronique Daneault Hélène Blais Sonia Frenette Dominique Lorrain Carol Hudon Célyne Bastien Dominique Petit Alexandre Lafrenière Cynthia Thompson Jacques Montplaisir Nadia Gosselin Julie Carrier |
| author_sort | Claire André |
| collection | DOAJ |
| description | Abstract Background Rapid-eye movement (REM) sleep highly depends on the activity of cholinergic basal forebrain (BF) neurons and is reduced in Alzheimer’s disease. Here, we investigated the associations between the volume of BF nuclei and REM sleep characteristics, and the impact of cognitive status on these links, in late middle-aged and older participants. Methods Thirty-one cognitively healthy controls (66.8 ± 7.2 years old, 13 women) and 31 participants with amnestic Mild Cognitive Impairment (aMCI) (68.3 ± 8.8 years old, 7 women) were included in this cross-sectional study. All participants underwent polysomnography, a comprehensive neuropsychological assessment and Magnetic Resonance Imaging examination. REM sleep characteristics (i.e., percentage, latency and efficiency) were derived from polysomnographic recordings. T1-weighted images were preprocessed using CAT12 and the DARTEL algorithm, and we extracted the gray matter volume of BF regions of interest using a probabilistic atlas implemented in the JuBrain Anatomy Toolbox. Multiple linear regressions were performed between the volume of BF nuclei and REM sleep characteristics controlling for age, sex and total intracranial volume, in the whole cohort and in subgroups stratified by cognitive status. Results In the whole sample, lower REM sleep percentage was significantly associated to lower nucleus basalis of Meynert (Ch4) volume (β = 0.32, p = 0.009). When stratifying the cohort according to cognitive status, lower REM sleep percentage was significantly associated to both lower Ch4 (β = 0.48, p = 0.012) and total BF volumes (β = 0.44, p = 0.014) in aMCI individuals, but not in cognitively unimpaired participants. No significant associations were observed between the volume of the BF and wake after sleep onset or non-REM sleep variables. Discussion These results suggest that REM sleep disturbances may be an early manifestation of the degeneration of the BF cholinergic system before the onset of dementia, especially in participants with mild memory deficits. |
| first_indexed | 2024-03-09T15:25:25Z |
| format | Article |
| id | doaj.art-810752662ffc48b581cb217e915d2cbb |
| institution | Directory Open Access Journal |
| issn | 1758-9193 |
| language | English |
| last_indexed | 2024-03-09T15:25:25Z |
| publishDate | 2023-09-01 |
| publisher | BMC |
| record_format | Article |
| series | Alzheimer’s Research & Therapy |
| spelling | doaj.art-810752662ffc48b581cb217e915d2cbb2023-11-26T12:33:01ZengBMCAlzheimer’s Research & Therapy1758-91932023-09-0115111110.1186/s13195-023-01265-yREM sleep is associated with the volume of the cholinergic basal forebrain in aMCI individualsClaire André0Marie-Ève Martineau-Dussault1Véronique Daneault2Hélène Blais3Sonia Frenette4Dominique Lorrain5Carol Hudon6Célyne Bastien7Dominique Petit8Alexandre Lafrenière9Cynthia Thompson10Jacques Montplaisir11Nadia Gosselin12Julie Carrier13Center for Advanced Research in Sleep Medicine, Hôpital du Sacré-Coeur de Montréal, Recherche CIUSSS NIMCenter for Advanced Research in Sleep Medicine, Hôpital du Sacré-Coeur de Montréal, Recherche CIUSSS NIMCenter for Advanced Research in Sleep Medicine, Hôpital du Sacré-Coeur de Montréal, Recherche CIUSSS NIMCenter for Advanced Research in Sleep Medicine, Hôpital du Sacré-Coeur de Montréal, Recherche CIUSSS NIMCenter for Advanced Research in Sleep Medicine, Hôpital du Sacré-Coeur de Montréal, Recherche CIUSSS NIMResearch Centre On Aging, University Institute of Geriatrics of Sherbrooke, CIUSSS de L’Estrie-CHUSCERVO Research CentreCERVO Research CentreCenter for Advanced Research in Sleep Medicine, Hôpital du Sacré-Coeur de Montréal, Recherche CIUSSS NIMCenter for Advanced Research in Sleep Medicine, Hôpital du Sacré-Coeur de Montréal, Recherche CIUSSS NIMCenter for Advanced Research in Sleep Medicine, Hôpital du Sacré-Coeur de Montréal, Recherche CIUSSS NIMCenter for Advanced Research in Sleep Medicine, Hôpital du Sacré-Coeur de Montréal, Recherche CIUSSS NIMCenter for Advanced Research in Sleep Medicine, Hôpital du Sacré-Coeur de Montréal, Recherche CIUSSS NIMCenter for Advanced Research in Sleep Medicine, Hôpital du Sacré-Coeur de Montréal, Recherche CIUSSS NIMAbstract Background Rapid-eye movement (REM) sleep highly depends on the activity of cholinergic basal forebrain (BF) neurons and is reduced in Alzheimer’s disease. Here, we investigated the associations between the volume of BF nuclei and REM sleep characteristics, and the impact of cognitive status on these links, in late middle-aged and older participants. Methods Thirty-one cognitively healthy controls (66.8 ± 7.2 years old, 13 women) and 31 participants with amnestic Mild Cognitive Impairment (aMCI) (68.3 ± 8.8 years old, 7 women) were included in this cross-sectional study. All participants underwent polysomnography, a comprehensive neuropsychological assessment and Magnetic Resonance Imaging examination. REM sleep characteristics (i.e., percentage, latency and efficiency) were derived from polysomnographic recordings. T1-weighted images were preprocessed using CAT12 and the DARTEL algorithm, and we extracted the gray matter volume of BF regions of interest using a probabilistic atlas implemented in the JuBrain Anatomy Toolbox. Multiple linear regressions were performed between the volume of BF nuclei and REM sleep characteristics controlling for age, sex and total intracranial volume, in the whole cohort and in subgroups stratified by cognitive status. Results In the whole sample, lower REM sleep percentage was significantly associated to lower nucleus basalis of Meynert (Ch4) volume (β = 0.32, p = 0.009). When stratifying the cohort according to cognitive status, lower REM sleep percentage was significantly associated to both lower Ch4 (β = 0.48, p = 0.012) and total BF volumes (β = 0.44, p = 0.014) in aMCI individuals, but not in cognitively unimpaired participants. No significant associations were observed between the volume of the BF and wake after sleep onset or non-REM sleep variables. Discussion These results suggest that REM sleep disturbances may be an early manifestation of the degeneration of the BF cholinergic system before the onset of dementia, especially in participants with mild memory deficits.https://doi.org/10.1186/s13195-023-01265-yREM SleepCholinergic Basal ForebrainNucleus Basalis of MeynertMild Cognitive ImpairmentNeurodegenerationAging |
| spellingShingle | Claire André Marie-Ève Martineau-Dussault Véronique Daneault Hélène Blais Sonia Frenette Dominique Lorrain Carol Hudon Célyne Bastien Dominique Petit Alexandre Lafrenière Cynthia Thompson Jacques Montplaisir Nadia Gosselin Julie Carrier REM sleep is associated with the volume of the cholinergic basal forebrain in aMCI individuals Alzheimer’s Research & Therapy REM Sleep Cholinergic Basal Forebrain Nucleus Basalis of Meynert Mild Cognitive Impairment Neurodegeneration Aging |
| title | REM sleep is associated with the volume of the cholinergic basal forebrain in aMCI individuals |
| title_full | REM sleep is associated with the volume of the cholinergic basal forebrain in aMCI individuals |
| title_fullStr | REM sleep is associated with the volume of the cholinergic basal forebrain in aMCI individuals |
| title_full_unstemmed | REM sleep is associated with the volume of the cholinergic basal forebrain in aMCI individuals |
| title_short | REM sleep is associated with the volume of the cholinergic basal forebrain in aMCI individuals |
| title_sort | rem sleep is associated with the volume of the cholinergic basal forebrain in amci individuals |
| topic | REM Sleep Cholinergic Basal Forebrain Nucleus Basalis of Meynert Mild Cognitive Impairment Neurodegeneration Aging |
| url | https://doi.org/10.1186/s13195-023-01265-y |
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