Possibility of Enlargement in Left Medial Temporal Areas Against Cerebral Amyloid Deposition Observed During Preclinical Stage
Neurodegenerative changes in the preclinical stage of Alzheimer’s disease (AD) have recently been the focus of attention because they may present a range of treatment opportunities. A total of 134 elderly volunteers who lived in a local community were investigated and grouped into preclinical and mi...
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| Format: | Article |
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Frontiers Media S.A.
2022-04-01
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| Series: | Frontiers in Aging Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnagi.2022.847094/full |
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| author | Etsuko Imabayashi Etsuko Imabayashi Kenji Ishii Jun Toyohara Kei Wagatsuma Kei Wagatsuma Muneyuki Sakata Tetsuro Tago Kenji Ishibashi Narumi Kojima Noriyuki Kohda Aya M. Tokumaru Hunkyung Kim |
| author_facet | Etsuko Imabayashi Etsuko Imabayashi Kenji Ishii Jun Toyohara Kei Wagatsuma Kei Wagatsuma Muneyuki Sakata Tetsuro Tago Kenji Ishibashi Narumi Kojima Noriyuki Kohda Aya M. Tokumaru Hunkyung Kim |
| author_sort | Etsuko Imabayashi |
| collection | DOAJ |
| description | Neurodegenerative changes in the preclinical stage of Alzheimer’s disease (AD) have recently been the focus of attention because they may present a range of treatment opportunities. A total of 134 elderly volunteers who lived in a local community were investigated and grouped into preclinical and mild cognitive impairment stages according to the Clinical Dementia Rating test; we also estimated amyloid deposition in the brain using positron emission tomography (PET). A significant interaction between clinical stage and amyloid PET positivity on cerebral atrophy was observed in the bilateral parietal lobe, parahippocampal gyri, hippocampus, fusiform gyrus, and right superior and middle temporal gyri, as previously reported. Early AD-specific voxel of interest (VOI) analysis was also applied and averaged Z-scores in the right, left, bilateral, and right minus left medial temporal early AD specific area were computed. We defined these averaged Z-scores in the right, left, bilateral, and right minus left early AD specific VOI in medial temporal area as R-MedT-Atrophy-score, L-MedT-Atrophy-score, Bil-MedT-Atrophy-score, and R_L-MedT-Atrophy-score, respectively. It revealed that the R_L-MedT-Atrophy-scores were significantly larger in the amyloid-positive than in the amyloid-negative cognitively normal (CN) elderly group, that is, the right medial temporal areas were smaller than left in amyloid positive CN group and these left-right differences were significantly larger in amyloid positive than amyloid negative CN elderly group. The L-MedT-Atrophy-score was slightly larger (p = 0.073), that is, the left medial temporal area was smaller in the amyloid-negative CN group than in the amyloid-positive CN group. Conclusively, the left medial temporal area could be larger in CN participants with amyloid deposition than in those without amyloid deposition. The area under the receiver operating characteristic curve for differentiating amyloid positivity among CN participants using the R_L-MedT-Atrophy-scores was 0.73; the sensitivity and specificity were 0.828 and 0.606, respectively. Although not significant, a negative correlation was observed between the composite cerebral standardized uptake value ratio in amyloid PET images and L-MedT-Atrophy-score in CN group. The left medial temporal volume might become enlarged because of compensatory effects against AD pathology occurring at the beginning of the amyloid deposition. |
| first_indexed | 2024-12-10T04:47:57Z |
| format | Article |
| id | doaj.art-8107d187fdba4e08845109a1a883a7a2 |
| institution | Directory Open Access Journal |
| issn | 1663-4365 |
| language | English |
| last_indexed | 2024-12-10T04:47:57Z |
| publishDate | 2022-04-01 |
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| series | Frontiers in Aging Neuroscience |
| spelling | doaj.art-8107d187fdba4e08845109a1a883a7a22022-12-22T02:01:41ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652022-04-011410.3389/fnagi.2022.847094847094Possibility of Enlargement in Left Medial Temporal Areas Against Cerebral Amyloid Deposition Observed During Preclinical StageEtsuko Imabayashi0Etsuko Imabayashi1Kenji Ishii2Jun Toyohara3Kei Wagatsuma4Kei Wagatsuma5Muneyuki Sakata6Tetsuro Tago7Kenji Ishibashi8Narumi Kojima9Noriyuki Kohda10Aya M. Tokumaru11Hunkyung Kim12Research Team for Neuroimaging, Tokyo Metropolitan Institute of Gerontology, Tokyo, JapanDiagnostic and Therapeutic Nuclear Medicine Group, Department of Molecular Imaging and Theranostics, Quantum Life and Medical Science Directorate, Institute for Quantum Medical Science, National Institutes for Quantum and Radiological Science and Technology, Chiba, JapanResearch Team for Neuroimaging, Tokyo Metropolitan Institute of Gerontology, Tokyo, JapanResearch Team for Neuroimaging, Tokyo Metropolitan Institute of Gerontology, Tokyo, JapanResearch Team for Neuroimaging, Tokyo Metropolitan Institute of Gerontology, Tokyo, JapanSchool of Allied Health Sciences, Kitasato University, Sagamihara, JapanResearch Team for Neuroimaging, Tokyo Metropolitan Institute of Gerontology, Tokyo, JapanResearch Team for Neuroimaging, Tokyo Metropolitan Institute of Gerontology, Tokyo, JapanResearch Team for Neuroimaging, Tokyo Metropolitan Institute of Gerontology, Tokyo, JapanResearch Team for Promoting Independence and Mental Health, Tokyo Metropolitan Institute of Gerontology, Tokyo, JapanNutraceuticals Division, Otsu Nutraceuticals Research Institute, Otsuka Pharmaceutical Co., Ltd., Tokyo, JapanDepartment of Radiology, Tokyo Metropolitan Institute of Gerontology, Tokyo, JapanResearch Team for Promoting Independence and Mental Health, Tokyo Metropolitan Institute of Gerontology, Tokyo, JapanNeurodegenerative changes in the preclinical stage of Alzheimer’s disease (AD) have recently been the focus of attention because they may present a range of treatment opportunities. A total of 134 elderly volunteers who lived in a local community were investigated and grouped into preclinical and mild cognitive impairment stages according to the Clinical Dementia Rating test; we also estimated amyloid deposition in the brain using positron emission tomography (PET). A significant interaction between clinical stage and amyloid PET positivity on cerebral atrophy was observed in the bilateral parietal lobe, parahippocampal gyri, hippocampus, fusiform gyrus, and right superior and middle temporal gyri, as previously reported. Early AD-specific voxel of interest (VOI) analysis was also applied and averaged Z-scores in the right, left, bilateral, and right minus left medial temporal early AD specific area were computed. We defined these averaged Z-scores in the right, left, bilateral, and right minus left early AD specific VOI in medial temporal area as R-MedT-Atrophy-score, L-MedT-Atrophy-score, Bil-MedT-Atrophy-score, and R_L-MedT-Atrophy-score, respectively. It revealed that the R_L-MedT-Atrophy-scores were significantly larger in the amyloid-positive than in the amyloid-negative cognitively normal (CN) elderly group, that is, the right medial temporal areas were smaller than left in amyloid positive CN group and these left-right differences were significantly larger in amyloid positive than amyloid negative CN elderly group. The L-MedT-Atrophy-score was slightly larger (p = 0.073), that is, the left medial temporal area was smaller in the amyloid-negative CN group than in the amyloid-positive CN group. Conclusively, the left medial temporal area could be larger in CN participants with amyloid deposition than in those without amyloid deposition. The area under the receiver operating characteristic curve for differentiating amyloid positivity among CN participants using the R_L-MedT-Atrophy-scores was 0.73; the sensitivity and specificity were 0.828 and 0.606, respectively. Although not significant, a negative correlation was observed between the composite cerebral standardized uptake value ratio in amyloid PET images and L-MedT-Atrophy-score in CN group. The left medial temporal volume might become enlarged because of compensatory effects against AD pathology occurring at the beginning of the amyloid deposition.https://www.frontiersin.org/articles/10.3389/fnagi.2022.847094/fullAlzheimer’s diseasecompensationvoxel-based morphometryMRIamyloidpreclinical |
| spellingShingle | Etsuko Imabayashi Etsuko Imabayashi Kenji Ishii Jun Toyohara Kei Wagatsuma Kei Wagatsuma Muneyuki Sakata Tetsuro Tago Kenji Ishibashi Narumi Kojima Noriyuki Kohda Aya M. Tokumaru Hunkyung Kim Possibility of Enlargement in Left Medial Temporal Areas Against Cerebral Amyloid Deposition Observed During Preclinical Stage Frontiers in Aging Neuroscience Alzheimer’s disease compensation voxel-based morphometry MRI amyloid preclinical |
| title | Possibility of Enlargement in Left Medial Temporal Areas Against Cerebral Amyloid Deposition Observed During Preclinical Stage |
| title_full | Possibility of Enlargement in Left Medial Temporal Areas Against Cerebral Amyloid Deposition Observed During Preclinical Stage |
| title_fullStr | Possibility of Enlargement in Left Medial Temporal Areas Against Cerebral Amyloid Deposition Observed During Preclinical Stage |
| title_full_unstemmed | Possibility of Enlargement in Left Medial Temporal Areas Against Cerebral Amyloid Deposition Observed During Preclinical Stage |
| title_short | Possibility of Enlargement in Left Medial Temporal Areas Against Cerebral Amyloid Deposition Observed During Preclinical Stage |
| title_sort | possibility of enlargement in left medial temporal areas against cerebral amyloid deposition observed during preclinical stage |
| topic | Alzheimer’s disease compensation voxel-based morphometry MRI amyloid preclinical |
| url | https://www.frontiersin.org/articles/10.3389/fnagi.2022.847094/full |
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