COVID-19 and Laboratory Markers from Romanian Patients—A Narrative Review
COVID-19 has significantly impacted the whole world, and Romania was no exception. Biomarkers play a crucial role in understanding and managing the disease. However, research regarding laboratory analyses for patients with COVID-19 is fairly limited. For detection, PCR testing is still considered th...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-08-01
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| Series: | Life |
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| Online Access: | https://www.mdpi.com/2075-1729/13/9/1837 |
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| author | Ovidiu Musat Virgiliu Bogdan Sorop Madalina Ioana Sorop Viorica Lazar Daniela Teodora Marti Monica Susan Cecilia Roberta Avram Andrada Oprisoni Dan Dumitru Vulcanescu Florin George Horhat Iulia Cristina Bagiu Delia Ioana Horhat Mircea Mihai Diaconu |
| author_facet | Ovidiu Musat Virgiliu Bogdan Sorop Madalina Ioana Sorop Viorica Lazar Daniela Teodora Marti Monica Susan Cecilia Roberta Avram Andrada Oprisoni Dan Dumitru Vulcanescu Florin George Horhat Iulia Cristina Bagiu Delia Ioana Horhat Mircea Mihai Diaconu |
| author_sort | Ovidiu Musat |
| collection | DOAJ |
| description | COVID-19 has significantly impacted the whole world, and Romania was no exception. Biomarkers play a crucial role in understanding and managing the disease. However, research regarding laboratory analyses for patients with COVID-19 is fairly limited. For detection, PCR testing is still considered the golden standard, while antibodies are still useful for monitoring both patients and their vaccination status. In our country, biomarkers such as CRP, LDH, transaminases, cardiac, and iron markers have been used to assess the status of patients and even predict illness outcome. CRP, IL-6, LDH, FER, fibrinogen, creatinine, and vitamin D levels have been associated with increased severity, risk of ICU admission, and death. Cardiac markers and D-dimers are also good predictors, but their role seems more important in patients with complications. HDL cholesterol and BUN levels were also suggested as potential biomarkers. Hematological issues in SARS-CoV-2 infections include neutrophilia, lymphopenia and their ratio, while PCT, which is a marker of bacterial infections, is better to be used in patients with co- or supra-infections. The current research is a narrative review that focuses on the laboratory results of Romanian COVID-19 patients. The goal of this article is to provide an update on the research on biomarkers and other laboratory tests conducted inside the borders of Romania and identify gaps in this regard. Secondly, options for further research are discussed and encouraged. |
| first_indexed | 2024-03-10T22:33:07Z |
| format | Article |
| id | doaj.art-810a6d1497b04d838010925a88ac9b1a |
| institution | Directory Open Access Journal |
| issn | 2075-1729 |
| language | English |
| last_indexed | 2024-03-10T22:33:07Z |
| publishDate | 2023-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Life |
| spelling | doaj.art-810a6d1497b04d838010925a88ac9b1a2023-11-19T11:36:59ZengMDPI AGLife2075-17292023-08-01139183710.3390/life13091837COVID-19 and Laboratory Markers from Romanian Patients—A Narrative ReviewOvidiu Musat0Virgiliu Bogdan Sorop1Madalina Ioana Sorop2Viorica Lazar3Daniela Teodora Marti4Monica Susan5Cecilia Roberta Avram6Andrada Oprisoni7Dan Dumitru Vulcanescu8Florin George Horhat9Iulia Cristina Bagiu10Delia Ioana Horhat11Mircea Mihai Diaconu12Department of Ophthalmology, “Carol Davila” University of Medicine and Pharmacy, Dionisie Lupu Street, No. 37, Sector 2, 020021 Bucharest, RomaniaDepartment of Obstetrics and Gynecology, “Victor Babes” University of Medicine and Pharmacy, Eftimie Murgu Square, No. 2, 300041 Timisoara, RomaniaDoctoral School, “Victor Babes” University of Medicine and Pharmacy, 300041 Timisoara, RomaniaDepartment of General Medicine, “Vasile Goldis” University of Medicine, Liviu Rebreanu Street, No. 86, 310048 Arad, RomaniaDepartment of Biology and Life Sciences, “Vasile Goldis” University of Medicine, Liviu Rebreanu Street, No. 86, 310048 Arad, RomaniaDepartment of Internal Medicine, Centre for Preventive Medicine, “Victor Babes” University of Medicine and Pharmacy, Eftimie Murgu Square, No. 2, 300041 Timisoara, RomaniaDepartment of Residential Training and Post-University Courses, “Vasile Goldis” Western University, Liviu Rebreanu Street 86, 310414 Arad, RomaniaDepartment of Pediatrics, Discipline of Pediatric Oncology and Hematology, “Victor Babes” University of Medicine and Pharmacy, Eftimie Murgu Square, No. 2, 300041 Timisoara, RomaniaDoctoral School, “Victor Babes” University of Medicine and Pharmacy, 300041 Timisoara, RomaniaDepartment of Microbiology, “Victor Babes” University of Medicine and Pharmacy, Eftimie Murgu Square, No. 2, 300041 Timisoara, RomaniaDepartment of Microbiology, “Victor Babes” University of Medicine and Pharmacy, Eftimie Murgu Square, No. 2, 300041 Timisoara, RomaniaDepartment of ENT, “Victor Babes” University of Medicine and Pharmacy, Eftimie Murgu Square, No. 2, 300041 Timisoara, RomaniaDepartment of Obstetrics and Gynecology, “Victor Babes” University of Medicine and Pharmacy, Eftimie Murgu Square, No. 2, 300041 Timisoara, RomaniaCOVID-19 has significantly impacted the whole world, and Romania was no exception. Biomarkers play a crucial role in understanding and managing the disease. However, research regarding laboratory analyses for patients with COVID-19 is fairly limited. For detection, PCR testing is still considered the golden standard, while antibodies are still useful for monitoring both patients and their vaccination status. In our country, biomarkers such as CRP, LDH, transaminases, cardiac, and iron markers have been used to assess the status of patients and even predict illness outcome. CRP, IL-6, LDH, FER, fibrinogen, creatinine, and vitamin D levels have been associated with increased severity, risk of ICU admission, and death. Cardiac markers and D-dimers are also good predictors, but their role seems more important in patients with complications. HDL cholesterol and BUN levels were also suggested as potential biomarkers. Hematological issues in SARS-CoV-2 infections include neutrophilia, lymphopenia and their ratio, while PCT, which is a marker of bacterial infections, is better to be used in patients with co- or supra-infections. The current research is a narrative review that focuses on the laboratory results of Romanian COVID-19 patients. The goal of this article is to provide an update on the research on biomarkers and other laboratory tests conducted inside the borders of Romania and identify gaps in this regard. Secondly, options for further research are discussed and encouraged.https://www.mdpi.com/2075-1729/13/9/1837COVID-19SARS-CoV-2laboratory markersbiomarkersdiagnostic |
| spellingShingle | Ovidiu Musat Virgiliu Bogdan Sorop Madalina Ioana Sorop Viorica Lazar Daniela Teodora Marti Monica Susan Cecilia Roberta Avram Andrada Oprisoni Dan Dumitru Vulcanescu Florin George Horhat Iulia Cristina Bagiu Delia Ioana Horhat Mircea Mihai Diaconu COVID-19 and Laboratory Markers from Romanian Patients—A Narrative Review Life COVID-19 SARS-CoV-2 laboratory markers biomarkers diagnostic |
| title | COVID-19 and Laboratory Markers from Romanian Patients—A Narrative Review |
| title_full | COVID-19 and Laboratory Markers from Romanian Patients—A Narrative Review |
| title_fullStr | COVID-19 and Laboratory Markers from Romanian Patients—A Narrative Review |
| title_full_unstemmed | COVID-19 and Laboratory Markers from Romanian Patients—A Narrative Review |
| title_short | COVID-19 and Laboratory Markers from Romanian Patients—A Narrative Review |
| title_sort | covid 19 and laboratory markers from romanian patients a narrative review |
| topic | COVID-19 SARS-CoV-2 laboratory markers biomarkers diagnostic |
| url | https://www.mdpi.com/2075-1729/13/9/1837 |
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