Association of serum angiopoietin-2 with malnutrition, inflammation, atherosclerosis and valvular calcification syndrome and outcome in peritoneal dialysis patients: a prospective cohort study
Abstract Background To examine serum angiopoietin-2 (Angpt-2) in relation to malnutrition, inflammation, atherosclerosis and cardiac valvular calcification, so-called MIAC syndrome and its predictive role in outcomes of peritoneal dialysis (PD) patients. Methods A prospective observational study was...
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| Format: | Article |
| Language: | English |
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BMC
2018-11-01
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| Series: | Journal of Translational Medicine |
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| Online Access: | http://link.springer.com/article/10.1186/s12967-018-1687-0 |
| _version_ | 1818954600750776320 |
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| author | Xiaoxiao Yang He Zhang Yuanyuan Shi Zanzhe Yu Hao Yan Zhaohui Ni Jiaqi Qian Wei Fang |
| author_facet | Xiaoxiao Yang He Zhang Yuanyuan Shi Zanzhe Yu Hao Yan Zhaohui Ni Jiaqi Qian Wei Fang |
| author_sort | Xiaoxiao Yang |
| collection | DOAJ |
| description | Abstract Background To examine serum angiopoietin-2 (Angpt-2) in relation to malnutrition, inflammation, atherosclerosis and cardiac valvular calcification, so-called MIAC syndrome and its predictive role in outcomes of peritoneal dialysis (PD) patients. Methods A prospective observational study was conducted in 324 chronic PD patients. Biochemical analysis was performed at baseline for serum angiopoietins, albumin and high sensitive C-reactive protein (hs-CRP) and echocardiography was done to detect cardiac valvular calcification. Primary study end points were fatal or nonfatal cardiovascular events and mortality. Results The median of serum Angpt-2 levels was 5.44 ng/mL (interquartile range, 3.41–7.85). Across the three tertiles of serum Angpt-2, a significant trend effect was observed for body mass index, normalized protein catabolic rate, calcium × phosphorus product, hs-CRP, brain natriuretic peptide, lower-density lipoprotein cholesterol, left ventricular ejection fraction, total weekly urea clearance and residual renal function (all p < 0.05). Serum Angpt-2 showed a significant increase across the four groups of patients with increasing components of MIAC syndrome (p < 0.001). There were 77 deaths and 57 cardiovascular events. High serum Angpt-2 was an independent predictor of fatal and nonfatal cardiovascular events in PD patients (p = 0.02), however serum Angpt-2 was not an independent predictor of all-cause mortality (p = 0.3). Conclusions Serum Angpt-2 showed close association with valvular calcification, atherosclerosis, inflammation and malnutrition, having significant independent prognostic value and is useful for cardiovascular event stratification in chronic PD patients. Angpt-2 might be a potential mediator of increased cardiovascular risk in patients undergoing PD treatment. |
| first_indexed | 2024-12-20T10:24:45Z |
| format | Article |
| id | doaj.art-810bbcd4702045cabbfc48be72597f63 |
| institution | Directory Open Access Journal |
| issn | 1479-5876 |
| language | English |
| last_indexed | 2024-12-20T10:24:45Z |
| publishDate | 2018-11-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Translational Medicine |
| spelling | doaj.art-810bbcd4702045cabbfc48be72597f632022-12-21T19:43:51ZengBMCJournal of Translational Medicine1479-58762018-11-0116111110.1186/s12967-018-1687-0Association of serum angiopoietin-2 with malnutrition, inflammation, atherosclerosis and valvular calcification syndrome and outcome in peritoneal dialysis patients: a prospective cohort studyXiaoxiao Yang0He Zhang1Yuanyuan Shi2Zanzhe Yu3Hao Yan4Zhaohui Ni5Jiaqi Qian6Wei Fang7Department of Nephrology, Renji Hospital, School of Medicine, Shanghai Jiao Tong UniversityDepartment of Nephrology, Renji Hospital, School of Medicine, Shanghai Jiao Tong UniversityDepartment of Nephrology, Renji Hospital, School of Medicine, Shanghai Jiao Tong UniversityDepartment of Nephrology, Renji Hospital, School of Medicine, Shanghai Jiao Tong UniversityDepartment of Nephrology, Renji Hospital, School of Medicine, Shanghai Jiao Tong UniversityDepartment of Nephrology, Renji Hospital, School of Medicine, Shanghai Jiao Tong UniversityDepartment of Nephrology, Renji Hospital, School of Medicine, Shanghai Jiao Tong UniversityDepartment of Nephrology, Renji Hospital, School of Medicine, Shanghai Jiao Tong UniversityAbstract Background To examine serum angiopoietin-2 (Angpt-2) in relation to malnutrition, inflammation, atherosclerosis and cardiac valvular calcification, so-called MIAC syndrome and its predictive role in outcomes of peritoneal dialysis (PD) patients. Methods A prospective observational study was conducted in 324 chronic PD patients. Biochemical analysis was performed at baseline for serum angiopoietins, albumin and high sensitive C-reactive protein (hs-CRP) and echocardiography was done to detect cardiac valvular calcification. Primary study end points were fatal or nonfatal cardiovascular events and mortality. Results The median of serum Angpt-2 levels was 5.44 ng/mL (interquartile range, 3.41–7.85). Across the three tertiles of serum Angpt-2, a significant trend effect was observed for body mass index, normalized protein catabolic rate, calcium × phosphorus product, hs-CRP, brain natriuretic peptide, lower-density lipoprotein cholesterol, left ventricular ejection fraction, total weekly urea clearance and residual renal function (all p < 0.05). Serum Angpt-2 showed a significant increase across the four groups of patients with increasing components of MIAC syndrome (p < 0.001). There were 77 deaths and 57 cardiovascular events. High serum Angpt-2 was an independent predictor of fatal and nonfatal cardiovascular events in PD patients (p = 0.02), however serum Angpt-2 was not an independent predictor of all-cause mortality (p = 0.3). Conclusions Serum Angpt-2 showed close association with valvular calcification, atherosclerosis, inflammation and malnutrition, having significant independent prognostic value and is useful for cardiovascular event stratification in chronic PD patients. Angpt-2 might be a potential mediator of increased cardiovascular risk in patients undergoing PD treatment.http://link.springer.com/article/10.1186/s12967-018-1687-0Angiopoietin-2AtherosclerosisCalcificationInflammationMalnutritionPeritoneal dialysis |
| spellingShingle | Xiaoxiao Yang He Zhang Yuanyuan Shi Zanzhe Yu Hao Yan Zhaohui Ni Jiaqi Qian Wei Fang Association of serum angiopoietin-2 with malnutrition, inflammation, atherosclerosis and valvular calcification syndrome and outcome in peritoneal dialysis patients: a prospective cohort study Journal of Translational Medicine Angiopoietin-2 Atherosclerosis Calcification Inflammation Malnutrition Peritoneal dialysis |
| title | Association of serum angiopoietin-2 with malnutrition, inflammation, atherosclerosis and valvular calcification syndrome and outcome in peritoneal dialysis patients: a prospective cohort study |
| title_full | Association of serum angiopoietin-2 with malnutrition, inflammation, atherosclerosis and valvular calcification syndrome and outcome in peritoneal dialysis patients: a prospective cohort study |
| title_fullStr | Association of serum angiopoietin-2 with malnutrition, inflammation, atherosclerosis and valvular calcification syndrome and outcome in peritoneal dialysis patients: a prospective cohort study |
| title_full_unstemmed | Association of serum angiopoietin-2 with malnutrition, inflammation, atherosclerosis and valvular calcification syndrome and outcome in peritoneal dialysis patients: a prospective cohort study |
| title_short | Association of serum angiopoietin-2 with malnutrition, inflammation, atherosclerosis and valvular calcification syndrome and outcome in peritoneal dialysis patients: a prospective cohort study |
| title_sort | association of serum angiopoietin 2 with malnutrition inflammation atherosclerosis and valvular calcification syndrome and outcome in peritoneal dialysis patients a prospective cohort study |
| topic | Angiopoietin-2 Atherosclerosis Calcification Inflammation Malnutrition Peritoneal dialysis |
| url | http://link.springer.com/article/10.1186/s12967-018-1687-0 |
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