Rare t(X;14)(q28;q32) translocation reveals link between MTCP1 and chronic lymphocytic leukemia
Some genes that are part of balanced translocations are reported as drivers for tumourigenesis. Here, the authors report a translocation involving MTCP1 in chronic lymphocytic leukemia and show that MTCP1 overexpression leads to the disease in a murine model.
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2021-11-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-021-26400-x |
| _version_ | 1818931245718962176 |
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| author | Janek S. Walker Zachary A. Hing Steven Sher James Cronin Katie Williams Bonnie Harrington Jordan N. Skinner Casey B. Cempre Charles T. Gregory Alexander Pan Max Yano Larry P. Beaver Brandi R. Walker Jadwiga M. Labanowska Nyla A. Heerema Krzysztof Mrózek Jennifer A. Woyach Amy S. Ruppert Amy Lehman Hatice Gulcin Ozer Vincenzo Coppola Pearlly Yan John C. Byrd James S. Blachly Rosa Lapalombella |
| author_facet | Janek S. Walker Zachary A. Hing Steven Sher James Cronin Katie Williams Bonnie Harrington Jordan N. Skinner Casey B. Cempre Charles T. Gregory Alexander Pan Max Yano Larry P. Beaver Brandi R. Walker Jadwiga M. Labanowska Nyla A. Heerema Krzysztof Mrózek Jennifer A. Woyach Amy S. Ruppert Amy Lehman Hatice Gulcin Ozer Vincenzo Coppola Pearlly Yan John C. Byrd James S. Blachly Rosa Lapalombella |
| author_sort | Janek S. Walker |
| collection | DOAJ |
| description | Some genes that are part of balanced translocations are reported as drivers for tumourigenesis. Here, the authors report a translocation involving MTCP1 in chronic lymphocytic leukemia and show that MTCP1 overexpression leads to the disease in a murine model. |
| first_indexed | 2024-12-20T04:13:32Z |
| format | Article |
| id | doaj.art-810bfd0089064a989b380ab83b7f18b0 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-20T04:13:32Z |
| publishDate | 2021-11-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-810bfd0089064a989b380ab83b7f18b02022-12-21T19:53:51ZengNature PortfolioNature Communications2041-17232021-11-0112111610.1038/s41467-021-26400-xRare t(X;14)(q28;q32) translocation reveals link between MTCP1 and chronic lymphocytic leukemiaJanek S. Walker0Zachary A. Hing1Steven Sher2James Cronin3Katie Williams4Bonnie Harrington5Jordan N. Skinner6Casey B. Cempre7Charles T. Gregory8Alexander Pan9Max Yano10Larry P. Beaver11Brandi R. Walker12Jadwiga M. Labanowska13Nyla A. Heerema14Krzysztof Mrózek15Jennifer A. Woyach16Amy S. Ruppert17Amy Lehman18Hatice Gulcin Ozer19Vincenzo Coppola20Pearlly Yan21John C. Byrd22James S. Blachly23Rosa Lapalombella24Division of Hematology, Department of Internal Medicine, The Ohio State UniversityDivision of Hematology, Department of Internal Medicine, The Ohio State UniversityDivision of Hematology, Department of Internal Medicine, The Ohio State UniversityDivision of Hematology, Department of Internal Medicine, The Ohio State UniversityDivision of Hematology, Department of Internal Medicine, The Ohio State UniversityDivision of Hematology, Department of Internal Medicine, The Ohio State UniversityDivision of Hematology, Department of Internal Medicine, The Ohio State UniversityDivision of Hematology, Department of Internal Medicine, The Ohio State UniversityDivision of Hematology, Department of Internal Medicine, The Ohio State UniversityDivision of Hematology, Department of Internal Medicine, The Ohio State UniversityDivision of Hematology, Department of Internal Medicine, The Ohio State UniversityDivision of Hematology, Department of Internal Medicine, The Ohio State UniversityDivision of Hematology, Department of Internal Medicine, The Ohio State UniversityDepartment of Pathology, The Ohio State UniversityDepartment of Pathology, The Ohio State UniversityThe Ohio State University Comprehensive Cancer Center, Clara D. Bloomfield Center for Leukemia Outcomes Research, The Ohio State UniversityDivision of Hematology, Department of Internal Medicine, The Ohio State UniversityDivision of Hematology, Department of Internal Medicine, The Ohio State UniversityCenter for Biostatistics, The Ohio State UniversityDepartment of Biomedical Informatics, The Ohio State University College of MedicineDepartment of Cancer Biology and Genetics, The Ohio State University College of MedicineDivision of Hematology, Department of Internal Medicine, The Ohio State UniversityDivision of Hematology, Department of Internal Medicine, The Ohio State UniversityDivision of Hematology, Department of Internal Medicine, The Ohio State UniversityDivision of Hematology, Department of Internal Medicine, The Ohio State UniversitySome genes that are part of balanced translocations are reported as drivers for tumourigenesis. Here, the authors report a translocation involving MTCP1 in chronic lymphocytic leukemia and show that MTCP1 overexpression leads to the disease in a murine model.https://doi.org/10.1038/s41467-021-26400-x |
| spellingShingle | Janek S. Walker Zachary A. Hing Steven Sher James Cronin Katie Williams Bonnie Harrington Jordan N. Skinner Casey B. Cempre Charles T. Gregory Alexander Pan Max Yano Larry P. Beaver Brandi R. Walker Jadwiga M. Labanowska Nyla A. Heerema Krzysztof Mrózek Jennifer A. Woyach Amy S. Ruppert Amy Lehman Hatice Gulcin Ozer Vincenzo Coppola Pearlly Yan John C. Byrd James S. Blachly Rosa Lapalombella Rare t(X;14)(q28;q32) translocation reveals link between MTCP1 and chronic lymphocytic leukemia Nature Communications |
| title | Rare t(X;14)(q28;q32) translocation reveals link between MTCP1 and chronic lymphocytic leukemia |
| title_full | Rare t(X;14)(q28;q32) translocation reveals link between MTCP1 and chronic lymphocytic leukemia |
| title_fullStr | Rare t(X;14)(q28;q32) translocation reveals link between MTCP1 and chronic lymphocytic leukemia |
| title_full_unstemmed | Rare t(X;14)(q28;q32) translocation reveals link between MTCP1 and chronic lymphocytic leukemia |
| title_short | Rare t(X;14)(q28;q32) translocation reveals link between MTCP1 and chronic lymphocytic leukemia |
| title_sort | rare t x 14 q28 q32 translocation reveals link between mtcp1 and chronic lymphocytic leukemia |
| url | https://doi.org/10.1038/s41467-021-26400-x |
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