The effects of bilateral prostriata lesions on spatial learning and memory in the rat
Area prostriata is the primary limbic structure for rapid response to the visual stimuli in the far peripheral visual field. Recent studies have revealed that the prostriata receives inputs not only from the visual and auditory cortices but also from many structures critical for spatial processing a...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2022-11-01
|
| Series: | Frontiers in Behavioral Neuroscience |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fnbeh.2022.1010321/full |
| _version_ | 1797984829458874368 |
|---|---|
| author | Shun-Yu Zhang Sheng-Qiang Chen Jin-Yuan Zhang Chang-Hui Chen Xiao-Jun Xiang Hui-Ru Cai Song-Lin Ding Song-Lin Ding |
| author_facet | Shun-Yu Zhang Sheng-Qiang Chen Jin-Yuan Zhang Chang-Hui Chen Xiao-Jun Xiang Hui-Ru Cai Song-Lin Ding Song-Lin Ding |
| author_sort | Shun-Yu Zhang |
| collection | DOAJ |
| description | Area prostriata is the primary limbic structure for rapid response to the visual stimuli in the far peripheral visual field. Recent studies have revealed that the prostriata receives inputs not only from the visual and auditory cortices but also from many structures critical for spatial processing and navigation. To gain insight into the functions of the prostriata in spatial learning and memory the present study examines the effects of bilateral lesions of the prostriata on motor ability, exploratory interest and spatial learning and memory using the open field, elevated plus-maze and Morris water maze tests. Our results show that the spatial learning and memory abilities of the rats with bilateral prostriata lesions are significantly reduced compared to the control and sham groups. In addition, the lesion rats are found to be less interested in space exploration and more anxious while the exercise capacity of the rats is not affected based on the first two behavioral tests. These findings suggest that the prostriata plays important roles in spatial learning and memory and may be involved in anxiety as well. |
| first_indexed | 2024-04-11T07:08:55Z |
| format | Article |
| id | doaj.art-810dedd1427f4e3f927424242c27e2aa |
| institution | Directory Open Access Journal |
| issn | 1662-5153 |
| language | English |
| last_indexed | 2024-04-11T07:08:55Z |
| publishDate | 2022-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Behavioral Neuroscience |
| spelling | doaj.art-810dedd1427f4e3f927424242c27e2aa2022-12-22T04:38:16ZengFrontiers Media S.A.Frontiers in Behavioral Neuroscience1662-51532022-11-011610.3389/fnbeh.2022.10103211010321The effects of bilateral prostriata lesions on spatial learning and memory in the ratShun-Yu Zhang0Sheng-Qiang Chen1Jin-Yuan Zhang2Chang-Hui Chen3Xiao-Jun Xiang4Hui-Ru Cai5Song-Lin Ding6Song-Lin Ding7Key Laboratory of Neuroscience, School of Basic Medical Sciences, Guangzhou Medical University, Guangzhou, ChinaDepartment of Psychology, School of Health Management, Guangzhou Medical University, Guangzhou, ChinaDepartment of Psychology, School of Health Management, Guangzhou Medical University, Guangzhou, ChinaKey Laboratory of Neuroscience, School of Basic Medical Sciences, Guangzhou Medical University, Guangzhou, ChinaKey Laboratory of Neuroscience, School of Basic Medical Sciences, Guangzhou Medical University, Guangzhou, ChinaKey Laboratory of Neuroscience, School of Basic Medical Sciences, Guangzhou Medical University, Guangzhou, ChinaKey Laboratory of Neuroscience, School of Basic Medical Sciences, Guangzhou Medical University, Guangzhou, ChinaAllen Institute for Brain Science, Seattle, WA, United StatesArea prostriata is the primary limbic structure for rapid response to the visual stimuli in the far peripheral visual field. Recent studies have revealed that the prostriata receives inputs not only from the visual and auditory cortices but also from many structures critical for spatial processing and navigation. To gain insight into the functions of the prostriata in spatial learning and memory the present study examines the effects of bilateral lesions of the prostriata on motor ability, exploratory interest and spatial learning and memory using the open field, elevated plus-maze and Morris water maze tests. Our results show that the spatial learning and memory abilities of the rats with bilateral prostriata lesions are significantly reduced compared to the control and sham groups. In addition, the lesion rats are found to be less interested in space exploration and more anxious while the exercise capacity of the rats is not affected based on the first two behavioral tests. These findings suggest that the prostriata plays important roles in spatial learning and memory and may be involved in anxiety as well.https://www.frontiersin.org/articles/10.3389/fnbeh.2022.1010321/fullprostriataopen field testelevated plus-maze testMorris water maze testspatial learning and memoryanxiety |
| spellingShingle | Shun-Yu Zhang Sheng-Qiang Chen Jin-Yuan Zhang Chang-Hui Chen Xiao-Jun Xiang Hui-Ru Cai Song-Lin Ding Song-Lin Ding The effects of bilateral prostriata lesions on spatial learning and memory in the rat Frontiers in Behavioral Neuroscience prostriata open field test elevated plus-maze test Morris water maze test spatial learning and memory anxiety |
| title | The effects of bilateral prostriata lesions on spatial learning and memory in the rat |
| title_full | The effects of bilateral prostriata lesions on spatial learning and memory in the rat |
| title_fullStr | The effects of bilateral prostriata lesions on spatial learning and memory in the rat |
| title_full_unstemmed | The effects of bilateral prostriata lesions on spatial learning and memory in the rat |
| title_short | The effects of bilateral prostriata lesions on spatial learning and memory in the rat |
| title_sort | effects of bilateral prostriata lesions on spatial learning and memory in the rat |
| topic | prostriata open field test elevated plus-maze test Morris water maze test spatial learning and memory anxiety |
| url | https://www.frontiersin.org/articles/10.3389/fnbeh.2022.1010321/full |
| work_keys_str_mv | AT shunyuzhang theeffectsofbilateralprostriatalesionsonspatiallearningandmemoryintherat AT shengqiangchen theeffectsofbilateralprostriatalesionsonspatiallearningandmemoryintherat AT jinyuanzhang theeffectsofbilateralprostriatalesionsonspatiallearningandmemoryintherat AT changhuichen theeffectsofbilateralprostriatalesionsonspatiallearningandmemoryintherat AT xiaojunxiang theeffectsofbilateralprostriatalesionsonspatiallearningandmemoryintherat AT huirucai theeffectsofbilateralprostriatalesionsonspatiallearningandmemoryintherat AT songlinding theeffectsofbilateralprostriatalesionsonspatiallearningandmemoryintherat AT songlinding theeffectsofbilateralprostriatalesionsonspatiallearningandmemoryintherat AT shunyuzhang effectsofbilateralprostriatalesionsonspatiallearningandmemoryintherat AT shengqiangchen effectsofbilateralprostriatalesionsonspatiallearningandmemoryintherat AT jinyuanzhang effectsofbilateralprostriatalesionsonspatiallearningandmemoryintherat AT changhuichen effectsofbilateralprostriatalesionsonspatiallearningandmemoryintherat AT xiaojunxiang effectsofbilateralprostriatalesionsonspatiallearningandmemoryintherat AT huirucai effectsofbilateralprostriatalesionsonspatiallearningandmemoryintherat AT songlinding effectsofbilateralprostriatalesionsonspatiallearningandmemoryintherat AT songlinding effectsofbilateralprostriatalesionsonspatiallearningandmemoryintherat |