Willin/FRMD6 Influences Mechanical Phenotype and Neuronal Differentiation in Mammalian Cells by Regulating ERK1/2 Activity

Willin/FRMD6 Influences Mechanical Phenotype and Neuronal Differentiation in Mammalian Cells by Regulating ERK1/2 Activity

Willin/FRMD6 is part of a family of proteins with a 4.1 ezrin-radixin-moesin (FERM) domain. It has been identified as an upstream activator of the Hippo pathway and, when aberrant in its expression, is associated with human diseases and disorders. Even though Willin/FRMD6 was originally discovered i...

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Bibliographic Details
Main Authors: Nils M. Kronenberg, Andrew Tilston-Lunel, Frances E. Thompson, Doris Chen, Wanjia Yu, Kishan Dholakia, Malte C. Gather, Frank J. Gunn-Moore
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-09-01
Series:Frontiers in Cellular Neuroscience
Subjects:
Willin/FRMD6
neuronal differentiation
ERK1/2
cell mechanics
actin
focal adhesion
Online Access:https://www.frontiersin.org/article/10.3389/fncel.2020.552213/full

Internet

https://www.frontiersin.org/article/10.3389/fncel.2020.552213/full

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