Time-dependent cytokines changes in ultra-rush wasp venom immunotherapy
Abstract Venom immunotherapy (VIT) represents a potential therapeutic approach for the management of venom allergies, aiming to modify the immune response to venom allergens and enhance its precision. Previous studies have demonstrated that VIT induces a shift in T helper cell responses from Th2 to...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2023-06-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-023-37593-0 |
| _version_ | 1797789782020980736 |
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| author | W. Urbańska L. Szymański M. Ciepelak A. Cios W. Stankiewicz E. Klimaszewska Krystyna Lieto Rafał Skopek A. Chciałowski S. Lewicki |
| author_facet | W. Urbańska L. Szymański M. Ciepelak A. Cios W. Stankiewicz E. Klimaszewska Krystyna Lieto Rafał Skopek A. Chciałowski S. Lewicki |
| author_sort | W. Urbańska |
| collection | DOAJ |
| description | Abstract Venom immunotherapy (VIT) represents a potential therapeutic approach for the management of venom allergies, aiming to modify the immune response to venom allergens and enhance its precision. Previous studies have demonstrated that VIT induces a shift in T helper cell responses from Th2 to Th1, characterized by the production of IL-2 and interferon-gamma by CD4+ and CD8+ cells. In order to explore long-term pathways following VIT treatment and verify potential new outcomes, the serum concentrations of 30 cytokines were assessed in a cohort of 61 patients (18 control, 43 study group) exhibiting hypersensitivity to wasp venom. Cytokine levels were measured at 0, 2, 6, and 24 weeks after the initiation phase of VIT in the study group. The present study found no significant alterations in the levels of IL-2 and IFN-γ in the peripheral blood following VIT. However, a noteworthy finding was the substantial increase in the concentration of IL-12, a cytokine capable of promoting the differentiation of Th0 cells into Th1 cells. This observation supports the involvement of the Th1 pathway in the desensitization process induced by VIT. Additionally, the study revealed a significant rise in the levels of IL-9 and TGF-β after VIT. These cytokines may play a role in the generation of inducible regulatory T (Treg) cells, indicating their potential importance in the immune response to venom allergens and the desensitization process associated with VIT. Nevertheless, further investigations are required to comprehend the underlying mechanisms driving the VIT process comprehensively. |
| first_indexed | 2024-03-13T01:55:32Z |
| format | Article |
| id | doaj.art-8111fb44c924466184c176c498f0bb2a |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-03-13T01:55:32Z |
| publishDate | 2023-06-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-8111fb44c924466184c176c498f0bb2a2023-07-02T11:14:13ZengNature PortfolioScientific Reports2045-23222023-06-0113111010.1038/s41598-023-37593-0Time-dependent cytokines changes in ultra-rush wasp venom immunotherapyW. Urbańska0L. Szymański1M. Ciepelak2A. Cios3W. Stankiewicz4E. Klimaszewska5Krystyna Lieto6Rafał Skopek7A. Chciałowski8S. Lewicki9Department of Infectious Diseases and Allergology, Military Institute of Medicine, National Research InstituteDepartment of Molecular Biology, Institute of Genetics and Animal Biotechnology, Polish Academy of SciencesDepartment of Microwave Safety, Military Institute of Hygiene and EpidemiologyDepartment of Hematological and Transfusion Immunology, Institute of Hematology and Transfusion MedicineFaculty of Health Sciences, The Mazovian State University in PłockFaculty of Medical Sciences and Health Sciences, Kazimierz Pulaski University of Technology and Humanities in RadomDepartment of Microwave Safety, Military Institute of Hygiene and EpidemiologyDepartment of Molecular Biology, Institute of Genetics and Animal Biotechnology, Polish Academy of SciencesDepartment of Infectious Diseases and Allergology, Military Institute of Medicine, National Research InstituteFaculty of Medical Sciences and Health Sciences, Kazimierz Pulaski University of Technology and Humanities in RadomAbstract Venom immunotherapy (VIT) represents a potential therapeutic approach for the management of venom allergies, aiming to modify the immune response to venom allergens and enhance its precision. Previous studies have demonstrated that VIT induces a shift in T helper cell responses from Th2 to Th1, characterized by the production of IL-2 and interferon-gamma by CD4+ and CD8+ cells. In order to explore long-term pathways following VIT treatment and verify potential new outcomes, the serum concentrations of 30 cytokines were assessed in a cohort of 61 patients (18 control, 43 study group) exhibiting hypersensitivity to wasp venom. Cytokine levels were measured at 0, 2, 6, and 24 weeks after the initiation phase of VIT in the study group. The present study found no significant alterations in the levels of IL-2 and IFN-γ in the peripheral blood following VIT. However, a noteworthy finding was the substantial increase in the concentration of IL-12, a cytokine capable of promoting the differentiation of Th0 cells into Th1 cells. This observation supports the involvement of the Th1 pathway in the desensitization process induced by VIT. Additionally, the study revealed a significant rise in the levels of IL-9 and TGF-β after VIT. These cytokines may play a role in the generation of inducible regulatory T (Treg) cells, indicating their potential importance in the immune response to venom allergens and the desensitization process associated with VIT. Nevertheless, further investigations are required to comprehend the underlying mechanisms driving the VIT process comprehensively.https://doi.org/10.1038/s41598-023-37593-0 |
| spellingShingle | W. Urbańska L. Szymański M. Ciepelak A. Cios W. Stankiewicz E. Klimaszewska Krystyna Lieto Rafał Skopek A. Chciałowski S. Lewicki Time-dependent cytokines changes in ultra-rush wasp venom immunotherapy Scientific Reports |
| title | Time-dependent cytokines changes in ultra-rush wasp venom immunotherapy |
| title_full | Time-dependent cytokines changes in ultra-rush wasp venom immunotherapy |
| title_fullStr | Time-dependent cytokines changes in ultra-rush wasp venom immunotherapy |
| title_full_unstemmed | Time-dependent cytokines changes in ultra-rush wasp venom immunotherapy |
| title_short | Time-dependent cytokines changes in ultra-rush wasp venom immunotherapy |
| title_sort | time dependent cytokines changes in ultra rush wasp venom immunotherapy |
| url | https://doi.org/10.1038/s41598-023-37593-0 |
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