Assessment of late cardiotoxic effects in patients treated for cancer in childhood
Abstract Background The most frequent chemotherapeutic regimens used in children's cancer contain anthracyclines, which may have potentially cardiotoxic effects even at a later point in time. Echocardiography including tissue Doppler imaging is well‐proved noninvasive method to assess cardiac f...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2022-04-01
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| Series: | Cancer Medicine |
| Online Access: | https://doi.org/10.1002/cam4.4564 |
| _version_ | 1817991429488640000 |
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| author | Vladimír Kincl Roman Panovský Tomáš Kepák Viera Bajčiová Veronika Bednárová Lukáš Opatřil Jan Máchal |
| author_facet | Vladimír Kincl Roman Panovský Tomáš Kepák Viera Bajčiová Veronika Bednárová Lukáš Opatřil Jan Máchal |
| author_sort | Vladimír Kincl |
| collection | DOAJ |
| description | Abstract Background The most frequent chemotherapeutic regimens used in children's cancer contain anthracyclines, which may have potentially cardiotoxic effects even at a later point in time. Echocardiography including tissue Doppler imaging is well‐proved noninvasive method to assess cardiac function. Objectives To assess the late cardiotoxic effects in young adults treated for various cancer types in childhood. Methods Ninety‐eight young adults who were treated for childhood cancer (CCS), median time 12.1 years after finishing the therapy, were comprised into study. All subjects underwent echocardiographic examination including tissue Doppler imaging. The echocardiographic parameters were compared to 57 healthy age‐matched subjects. The CCS group also underwent 24‐h ECG Holter monitoring to reveal any arrhythmias. Results The subjects in CCS group had lower E′ velocities from lateral (15.6 vs. 17.6 cm/s) and septal part (12.2 vs. 14.4 cm/s) of mitral annulus (p for both <0.001) and also lower S′ velocity from the tricuspid annulus (12.4. vs. 13.3 cm/s, p = 0.013) and tricuspid annulus peak systolic excursion (TAPSE; 22.2 vs. 23.9 mm, p = 0.017). There were no significant differences in left ventricular systolic velocities or ejection fraction. The occurrence of arrhythmias did not differ among subgroups of CCS with or without anthracycline therapy. Conclusion Childhood cancer survivors had subclinical cardiac impairment in comparison with healthy controls, particularly in left ventricular diastolic function. |
| first_indexed | 2024-04-14T01:12:21Z |
| format | Article |
| id | doaj.art-81134d4e473647749660a95b5cfa2ab9 |
| institution | Directory Open Access Journal |
| issn | 2045-7634 |
| language | English |
| last_indexed | 2024-04-14T01:12:21Z |
| publishDate | 2022-04-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cancer Medicine |
| spelling | doaj.art-81134d4e473647749660a95b5cfa2ab92022-12-22T02:20:59ZengWileyCancer Medicine2045-76342022-04-011181763176810.1002/cam4.4564Assessment of late cardiotoxic effects in patients treated for cancer in childhoodVladimír Kincl0Roman Panovský1Tomáš Kepák2Viera Bajčiová3Veronika Bednárová4Lukáš Opatřil5Jan Máchal6Department of Internal Medicine/Cardiology St. Anne's University Hospital, Faculty of Medicine, Masaryk University Brno Czech RepublicDepartment of Internal Medicine/Cardiology St. Anne's University Hospital, Faculty of Medicine, Masaryk University Brno Czech RepublicInternational Clinical Research Center St. Anne's University Hospital Brno Czech RepublicInternational Clinical Research Center St. Anne's University Hospital Brno Czech RepublicDepartment of Internal Medicine/Cardiology St. Anne's University Hospital, Faculty of Medicine, Masaryk University Brno Czech RepublicDepartment of Internal Medicine/Cardiology St. Anne's University Hospital, Faculty of Medicine, Masaryk University Brno Czech RepublicInternational Clinical Research Center St. Anne's University Hospital Brno Czech RepublicAbstract Background The most frequent chemotherapeutic regimens used in children's cancer contain anthracyclines, which may have potentially cardiotoxic effects even at a later point in time. Echocardiography including tissue Doppler imaging is well‐proved noninvasive method to assess cardiac function. Objectives To assess the late cardiotoxic effects in young adults treated for various cancer types in childhood. Methods Ninety‐eight young adults who were treated for childhood cancer (CCS), median time 12.1 years after finishing the therapy, were comprised into study. All subjects underwent echocardiographic examination including tissue Doppler imaging. The echocardiographic parameters were compared to 57 healthy age‐matched subjects. The CCS group also underwent 24‐h ECG Holter monitoring to reveal any arrhythmias. Results The subjects in CCS group had lower E′ velocities from lateral (15.6 vs. 17.6 cm/s) and septal part (12.2 vs. 14.4 cm/s) of mitral annulus (p for both <0.001) and also lower S′ velocity from the tricuspid annulus (12.4. vs. 13.3 cm/s, p = 0.013) and tricuspid annulus peak systolic excursion (TAPSE; 22.2 vs. 23.9 mm, p = 0.017). There were no significant differences in left ventricular systolic velocities or ejection fraction. The occurrence of arrhythmias did not differ among subgroups of CCS with or without anthracycline therapy. Conclusion Childhood cancer survivors had subclinical cardiac impairment in comparison with healthy controls, particularly in left ventricular diastolic function.https://doi.org/10.1002/cam4.4564 |
| spellingShingle | Vladimír Kincl Roman Panovský Tomáš Kepák Viera Bajčiová Veronika Bednárová Lukáš Opatřil Jan Máchal Assessment of late cardiotoxic effects in patients treated for cancer in childhood Cancer Medicine |
| title | Assessment of late cardiotoxic effects in patients treated for cancer in childhood |
| title_full | Assessment of late cardiotoxic effects in patients treated for cancer in childhood |
| title_fullStr | Assessment of late cardiotoxic effects in patients treated for cancer in childhood |
| title_full_unstemmed | Assessment of late cardiotoxic effects in patients treated for cancer in childhood |
| title_short | Assessment of late cardiotoxic effects in patients treated for cancer in childhood |
| title_sort | assessment of late cardiotoxic effects in patients treated for cancer in childhood |
| url | https://doi.org/10.1002/cam4.4564 |
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