The Checkpoint Regulator SLAMF3 Preferentially Prevents Expansion of Auto-Reactive B Cells Generated by Graft-vs.-Host Disease

The Checkpoint Regulator SLAMF3 Preferentially Prevents Expansion of Auto-Reactive B Cells Generated by Graft-vs.-Host Disease

Absence of the mouse cell surface receptor SLAMF3 in SLAMF3-/- mice suggested that this receptor negatively regulates B cell homeostasis by modulating activation thresholds of B cell subsets. Here, we examine whether anti-SLAMF3 affects both B and T cell subsets during immune responses to haptenated...

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Bibliographic Details
Main Authors: Ninghai Wang, Burcu Yigit, Cees E. van der Poel, Marta Cuenca, Michael C. Carroll, Roland W. Herzog, Pablo Engel, Cox Terhorst
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-04-01
Series:Frontiers in Immunology
Subjects:
SLAMF3
cGVHD
B cells
autoreactive
alloimmunity
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.00831/full

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