m6A RNA methylation in brain injury and neurodegenerative disease
N6-methyladenosine (m6A), the most prevalent post-transcriptional RNA modification throughout the eukaryotic transcriptome, participates in diverse biophysiological processes including cell fates, embryonic development and stress responses. Accumulating evidence suggests that m6A modification in neu...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2022-09-01
|
| Series: | Frontiers in Neurology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2022.995747/full |
| _version_ | 1811275648851771392 |
|---|---|
| author | Jianhui Deng Xiaohui Chen Andi Chen Xiaochun Zheng Xiaochun Zheng |
| author_facet | Jianhui Deng Xiaohui Chen Andi Chen Xiaochun Zheng Xiaochun Zheng |
| author_sort | Jianhui Deng |
| collection | DOAJ |
| description | N6-methyladenosine (m6A), the most prevalent post-transcriptional RNA modification throughout the eukaryotic transcriptome, participates in diverse biophysiological processes including cell fates, embryonic development and stress responses. Accumulating evidence suggests that m6A modification in neural development and differentiation are highly regulated processes. As RNA m6A is crucial to protein translation and various bioprocesses, its modification dysregulation may also be associated with brain injury. This review highlights the biological significance of m6A modification in neurodegenerative disease and brain injury, including cerebrovascular disorders, is highlighted. Emphasis is placed on recent findings that elucidate the relevant molecular functional mechanism of m6A modification after brain injury and neurodegenerative disease. Finally, a neurobiological basis for further investigation of potential treatments is described. |
| first_indexed | 2024-04-12T23:42:40Z |
| format | Article |
| id | doaj.art-811589740c26428c827189d1744c2fcd |
| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-04-12T23:42:40Z |
| publishDate | 2022-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj.art-811589740c26428c827189d1744c2fcd2022-12-22T03:11:57ZengFrontiers Media S.A.Frontiers in Neurology1664-22952022-09-011310.3389/fneur.2022.995747995747m6A RNA methylation in brain injury and neurodegenerative diseaseJianhui Deng0Xiaohui Chen1Andi Chen2Xiaochun Zheng3Xiaochun Zheng4Department of Anesthesiology, Fujian Provincial Hospital, Shengli Clinical Medical College of Fujian Medical University, Fuzhou, ChinaDepartment of Anesthesiology, Fujian Provincial Hospital, Shengli Clinical Medical College of Fujian Medical University, Fuzhou, ChinaDepartment of Anesthesiology, Fujian Provincial Hospital, Shengli Clinical Medical College of Fujian Medical University, Fuzhou, ChinaDepartment of Anesthesiology, Fujian Provincial Hospital, Shengli Clinical Medical College of Fujian Medical University, Fuzhou, ChinaFujian Provincial Key Laboratory of Emergency Medicine, Fujian Provincial Key Laboratory of Critical Care Medicine, Fujian Provincial Co-Constructed Laboratory of “Belt and Road,” Fujian Emergency Medical Center, Fuzhou, ChinaN6-methyladenosine (m6A), the most prevalent post-transcriptional RNA modification throughout the eukaryotic transcriptome, participates in diverse biophysiological processes including cell fates, embryonic development and stress responses. Accumulating evidence suggests that m6A modification in neural development and differentiation are highly regulated processes. As RNA m6A is crucial to protein translation and various bioprocesses, its modification dysregulation may also be associated with brain injury. This review highlights the biological significance of m6A modification in neurodegenerative disease and brain injury, including cerebrovascular disorders, is highlighted. Emphasis is placed on recent findings that elucidate the relevant molecular functional mechanism of m6A modification after brain injury and neurodegenerative disease. Finally, a neurobiological basis for further investigation of potential treatments is described.https://www.frontiersin.org/articles/10.3389/fneur.2022.995747/fullN6-methyladenosinepost-transcriptional RNA modificationRNAbrain injuryneurodegenerative disease |
| spellingShingle | Jianhui Deng Xiaohui Chen Andi Chen Xiaochun Zheng Xiaochun Zheng m6A RNA methylation in brain injury and neurodegenerative disease Frontiers in Neurology N6-methyladenosine post-transcriptional RNA modification RNA brain injury neurodegenerative disease |
| title | m6A RNA methylation in brain injury and neurodegenerative disease |
| title_full | m6A RNA methylation in brain injury and neurodegenerative disease |
| title_fullStr | m6A RNA methylation in brain injury and neurodegenerative disease |
| title_full_unstemmed | m6A RNA methylation in brain injury and neurodegenerative disease |
| title_short | m6A RNA methylation in brain injury and neurodegenerative disease |
| title_sort | m6a rna methylation in brain injury and neurodegenerative disease |
| topic | N6-methyladenosine post-transcriptional RNA modification RNA brain injury neurodegenerative disease |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2022.995747/full |
| work_keys_str_mv | AT jianhuideng m6arnamethylationinbraininjuryandneurodegenerativedisease AT xiaohuichen m6arnamethylationinbraininjuryandneurodegenerativedisease AT andichen m6arnamethylationinbraininjuryandneurodegenerativedisease AT xiaochunzheng m6arnamethylationinbraininjuryandneurodegenerativedisease AT xiaochunzheng m6arnamethylationinbraininjuryandneurodegenerativedisease |