Imbalance of heterologous protein folding and disulfide bond formation rates yields runaway oxidative stress

Imbalance of heterologous protein folding and disulfide bond formation rates yields runaway oxidative stress

<p>Abstract</p> <p>Background</p> <p>The protein secretory pathway must process a wide assortment of native proteins for eukaryotic cells to function. As well, recombinant protein secretion is used extensively to produce many biologics and industrial enzymes. Therefore,...

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Bibliographic Details
Main Authors: Tyo Keith EJ, Liu Zihe, Petranovic Dina, Nielsen Jens
Format: Article
Language:English
Published: BMC 2012-03-01
Series:BMC Biology
Subjects:
Protein secretion
unfolded protein response
<it>HAC1</it>
protein production
oxidative stress
Online Access:http://www.biomedcentral.com/1741-7007/10/16

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