Neurodevelopmental Outcomes and Brain Volumetric Analysis of Low-Grade Intraventricular Hemorrhage
Purpose Extremely preterm infants are prone to brain injury and underdevelopment. Intraventricular hemorrhage (IVH) is the most common cause of brain injury and a significant risk factor for neurodevelopmental delay in preterm infants. Severe IVH is known to have a poor outcome; however, the outcome...
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| Format: | Article |
| Language: | English |
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Korean Society of Neonatology
2023-05-01
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| Series: | Neonatal Medicine |
| Subjects: | |
| Online Access: | http://neo-med.org/upload/pdf/nm-2023-30-2-42.pdf |
| _version_ | 1827931058457280512 |
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| author | Seul Gi Park Hyo Ju Yang Soo Yeon Lim Seh Hyun Kim Seung Han Shin Ee-Kyung Kim Han-Suk Kim |
| author_facet | Seul Gi Park Hyo Ju Yang Soo Yeon Lim Seh Hyun Kim Seung Han Shin Ee-Kyung Kim Han-Suk Kim |
| author_sort | Seul Gi Park |
| collection | DOAJ |
| description | Purpose Extremely preterm infants are prone to brain injury and underdevelopment. Intraventricular hemorrhage (IVH) is the most common cause of brain injury and a significant risk factor for neurodevelopmental delay in preterm infants. Severe IVH is known to have a poor outcome; however, the outcomes of low-grade IVH remain controversial. This study aimed to evaluate neurodevelopmental outcomes and brain segmental volumes of preterm infants with low-grade IVH. Methods This retrospective cohort study included 109 extremely preterm infants who underwent term equivalent age-magnetic resonance imaging and neurodevelopmental evaluation at a corrected age of 18 to 24 months. We compared infants with and without low-grade IVH. Results Among the 109 extremely preterm infants, 25 had low-grade IVH and 84 had no IVH. There were no significant differences in the neurodevelopmental outcomes between the low-grade and no IVH groups. In multivariate analysis, low-grade IVH was associated with a smaller medullary volume (adjusted odds ratio, 0.575; 95% confidence interval, 0.346 to 0.957; P=0.034). Conclusion We found no significant differences in the neurodevelopmental outcomes of extremely preterm infants at a corrected age of 18 to 24 months between those with low-grade IVH and those without IVH. Low-grade IVH was associated with a smaller medullary volume. |
| first_indexed | 2024-03-13T06:46:24Z |
| format | Article |
| id | doaj.art-8116e9ad1b8441b6997b4056ec608c3a |
| institution | Directory Open Access Journal |
| issn | 2287-9412 2287-9803 |
| language | English |
| last_indexed | 2024-03-13T06:46:24Z |
| publishDate | 2023-05-01 |
| publisher | Korean Society of Neonatology |
| record_format | Article |
| series | Neonatal Medicine |
| spelling | doaj.art-8116e9ad1b8441b6997b4056ec608c3a2023-06-08T05:59:50ZengKorean Society of NeonatologyNeonatal Medicine2287-94122287-98032023-05-01302424810.5385/nm.2023.30.2.421082Neurodevelopmental Outcomes and Brain Volumetric Analysis of Low-Grade Intraventricular HemorrhageSeul Gi Park0Hyo Ju Yang1Soo Yeon Lim2Seh Hyun KimSeung Han Shin3Ee-Kyung Kim4Han-Suk Kim5 Department of Pediatrics, Seoul National University Children’s Hospital, Seoul National University College of Medicine, Seoul, Korea Department of Pediatrics, Seoul National University Children’s Hospital, Seoul National University College of Medicine, Seoul, Korea Department of Pediatrics, Seoul National University Children’s Hospital, Seoul National University College of Medicine, Seoul, Korea Department of Pediatrics, Seoul National University Children’s Hospital, Seoul National University College of Medicine, Seoul, Korea Department of Pediatrics, Seoul National University Children’s Hospital, Seoul National University College of Medicine, Seoul, Korea Department of Pediatrics, Seoul National University Children’s Hospital, Seoul National University College of Medicine, Seoul, KoreaPurpose Extremely preterm infants are prone to brain injury and underdevelopment. Intraventricular hemorrhage (IVH) is the most common cause of brain injury and a significant risk factor for neurodevelopmental delay in preterm infants. Severe IVH is known to have a poor outcome; however, the outcomes of low-grade IVH remain controversial. This study aimed to evaluate neurodevelopmental outcomes and brain segmental volumes of preterm infants with low-grade IVH. Methods This retrospective cohort study included 109 extremely preterm infants who underwent term equivalent age-magnetic resonance imaging and neurodevelopmental evaluation at a corrected age of 18 to 24 months. We compared infants with and without low-grade IVH. Results Among the 109 extremely preterm infants, 25 had low-grade IVH and 84 had no IVH. There were no significant differences in the neurodevelopmental outcomes between the low-grade and no IVH groups. In multivariate analysis, low-grade IVH was associated with a smaller medullary volume (adjusted odds ratio, 0.575; 95% confidence interval, 0.346 to 0.957; P=0.034). Conclusion We found no significant differences in the neurodevelopmental outcomes of extremely preterm infants at a corrected age of 18 to 24 months between those with low-grade IVH and those without IVH. Low-grade IVH was associated with a smaller medullary volume.http://neo-med.org/upload/pdf/nm-2023-30-2-42.pdfprematurityintraventricular hemorrhagebrain regionsneurodevelopmental disorders |
| spellingShingle | Seul Gi Park Hyo Ju Yang Soo Yeon Lim Seh Hyun Kim Seung Han Shin Ee-Kyung Kim Han-Suk Kim Neurodevelopmental Outcomes and Brain Volumetric Analysis of Low-Grade Intraventricular Hemorrhage Neonatal Medicine prematurity intraventricular hemorrhage brain regions neurodevelopmental disorders |
| title | Neurodevelopmental Outcomes and Brain Volumetric Analysis of Low-Grade Intraventricular Hemorrhage |
| title_full | Neurodevelopmental Outcomes and Brain Volumetric Analysis of Low-Grade Intraventricular Hemorrhage |
| title_fullStr | Neurodevelopmental Outcomes and Brain Volumetric Analysis of Low-Grade Intraventricular Hemorrhage |
| title_full_unstemmed | Neurodevelopmental Outcomes and Brain Volumetric Analysis of Low-Grade Intraventricular Hemorrhage |
| title_short | Neurodevelopmental Outcomes and Brain Volumetric Analysis of Low-Grade Intraventricular Hemorrhage |
| title_sort | neurodevelopmental outcomes and brain volumetric analysis of low grade intraventricular hemorrhage |
| topic | prematurity intraventricular hemorrhage brain regions neurodevelopmental disorders |
| url | http://neo-med.org/upload/pdf/nm-2023-30-2-42.pdf |
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