Cortical network formation based on subthalamic beta bursts in Parkinson's disease
Recent evidence suggests that beta bursts in subthalamic nucleus (STN) play an important role in Parkinsonian pathophysiology.We studied the spatio-temporal relationship between STN beta bursts and cortical activity in 26 Parkinson's disease (PD) patients undergoing deep brain stimulation (DBS)...
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| Format: | Article |
| Language: | English |
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Elsevier
2022-11-01
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| Series: | NeuroImage |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1053811922007340 |
| _version_ | 1811192604450095104 |
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| author | Matthias Sure Jan Vesper Alfons Schnitzler Esther Florin |
| author_facet | Matthias Sure Jan Vesper Alfons Schnitzler Esther Florin |
| author_sort | Matthias Sure |
| collection | DOAJ |
| description | Recent evidence suggests that beta bursts in subthalamic nucleus (STN) play an important role in Parkinsonian pathophysiology.We studied the spatio-temporal relationship between STN beta bursts and cortical activity in 26 Parkinson's disease (PD) patients undergoing deep brain stimulation (DBS) surgery. Postoperatively, we simultaneously recorded STN local field potentials (LFP) from externalized DBS leads and cortical activity using whole-brain magnetoencephalography. Event-related magnetic fields (ERF) were averaged time-locked to STN beta bursts and subjected to source localization.Our results demonstrate that ERF exhibiting activity significantly different from baseline activity were localized within areas functionally related to associative, limbic, and motor systems as well as regions pertinent for visual and language processing.Our data suggest that STN beta bursts are involved in network formation between STN and cortex. This interaction is in line with the idea of parallel processing within the basal ganglia-cortex loop, specifically within the functional subsystems of the STN (i.e., associative, limbic, motor, and the related cortical areas). ERFs within visual and language-related cortical areas indicate involvement of beta bursts in STN-cortex networks beyond the associative, limbic, and motor loops.In sum, our results highlight the involvement of STN beta bursts in the formation of multiple STN - cortex loops in patients with PD. |
| first_indexed | 2024-04-11T23:55:14Z |
| format | Article |
| id | doaj.art-81173e5247f0447fb11eb781ae2235f1 |
| institution | Directory Open Access Journal |
| issn | 1095-9572 |
| language | English |
| last_indexed | 2024-04-11T23:55:14Z |
| publishDate | 2022-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | NeuroImage |
| spelling | doaj.art-81173e5247f0447fb11eb781ae2235f12022-12-22T03:56:23ZengElsevierNeuroImage1095-95722022-11-01263119619Cortical network formation based on subthalamic beta bursts in Parkinson's diseaseMatthias Sure0Jan Vesper1Alfons Schnitzler2Esther Florin3Institute of Clinical Neuroscience and Medical Psychology, Medical Faculty, Heinrich-Heine University Düsseldorf, Düsseldorf, Germany; Corresponding authors.Department of Functional Neurosurgery and Stereotaxy, Medical Faculty, University Hospital Düsseldorf, Düsseldorf, GermanyInstitute of Clinical Neuroscience and Medical Psychology, Medical Faculty, Heinrich-Heine University Düsseldorf, Düsseldorf, Germany; Department of Neurology, Center for Movement Disorders and Neuromodulation, Medical Faculty, University Hospital Düsseldorf, Düsseldorf, GermanyInstitute of Clinical Neuroscience and Medical Psychology, Medical Faculty, Heinrich-Heine University Düsseldorf, Düsseldorf, Germany; Corresponding authors.Recent evidence suggests that beta bursts in subthalamic nucleus (STN) play an important role in Parkinsonian pathophysiology.We studied the spatio-temporal relationship between STN beta bursts and cortical activity in 26 Parkinson's disease (PD) patients undergoing deep brain stimulation (DBS) surgery. Postoperatively, we simultaneously recorded STN local field potentials (LFP) from externalized DBS leads and cortical activity using whole-brain magnetoencephalography. Event-related magnetic fields (ERF) were averaged time-locked to STN beta bursts and subjected to source localization.Our results demonstrate that ERF exhibiting activity significantly different from baseline activity were localized within areas functionally related to associative, limbic, and motor systems as well as regions pertinent for visual and language processing.Our data suggest that STN beta bursts are involved in network formation between STN and cortex. This interaction is in line with the idea of parallel processing within the basal ganglia-cortex loop, specifically within the functional subsystems of the STN (i.e., associative, limbic, motor, and the related cortical areas). ERFs within visual and language-related cortical areas indicate involvement of beta bursts in STN-cortex networks beyond the associative, limbic, and motor loops.In sum, our results highlight the involvement of STN beta bursts in the formation of multiple STN - cortex loops in patients with PD.http://www.sciencedirect.com/science/article/pii/S1053811922007340Beta burstsEvent-related fieldsMEGPDResting stateBasal ganglia-cortical loop |
| spellingShingle | Matthias Sure Jan Vesper Alfons Schnitzler Esther Florin Cortical network formation based on subthalamic beta bursts in Parkinson's disease NeuroImage Beta bursts Event-related fields MEG PD Resting state Basal ganglia-cortical loop |
| title | Cortical network formation based on subthalamic beta bursts in Parkinson's disease |
| title_full | Cortical network formation based on subthalamic beta bursts in Parkinson's disease |
| title_fullStr | Cortical network formation based on subthalamic beta bursts in Parkinson's disease |
| title_full_unstemmed | Cortical network formation based on subthalamic beta bursts in Parkinson's disease |
| title_short | Cortical network formation based on subthalamic beta bursts in Parkinson's disease |
| title_sort | cortical network formation based on subthalamic beta bursts in parkinson s disease |
| topic | Beta bursts Event-related fields MEG PD Resting state Basal ganglia-cortical loop |
| url | http://www.sciencedirect.com/science/article/pii/S1053811922007340 |
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