Sequential CT Findings in Two Cases of Immunoglobulin G4-Related Lung Disease: Focused on Disease Progression

Immunoglobulin G4 (IgG4)-related lung disease has been actively studied over the past few years. Radiologic findings of IgG4-related lung disease vary among patients, but there are no long-term follow up studies regarding variations in imaging features over the course of disease progression. In two...

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Päätekijät: Dong-Kyu Lee, Soo-Youn Ham
Aineistotyyppi: Artikkeli
Kieli:English
Julkaistu: The Korean Society of Radiology 2018-11-01
Sarja:대한영상의학회지
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Linkit:https://doi.org/10.3348/jksr.2018.79.5.276
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author Dong-Kyu Lee
Soo-Youn Ham
author_facet Dong-Kyu Lee
Soo-Youn Ham
author_sort Dong-Kyu Lee
collection DOAJ
description Immunoglobulin G4 (IgG4)-related lung disease has been actively studied over the past few years. Radiologic findings of IgG4-related lung disease vary among patients, but there are no long-term follow up studies regarding variations in imaging features over the course of disease progression. In two cases with relatively long-term follow up, diverse early and late computed tomography (CT) findings of IgG4-related lung disease are reviewed in this report. In contrast to nodular or diffuse ground-glass opacity, which was predominantly noted in CT scans at earlier stages of disease, honeycombing and traction bronchiectasis were regarded as late radiologic manifestations. Solid nodules might be visible in both early and late stages; however, development of new solid nodules and enlargement of preexisting nodules could occur during disease progression. Interlobular septal thickening and mediastinal/hilar lymphadenopathy were persistent, even in later stages of the disease. These findings might be useful in making an accurate and timely diagnosis of IgG4-related lung disease.
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spelling doaj.art-8118b51a79a5454cb3315a6443cf6c7e2022-12-21T23:32:33ZengThe Korean Society of Radiology대한영상의학회지1738-26372288-29282018-11-01795276281https://doi.org/10.3348/jksr.2018.79.5.276Sequential CT Findings in Two Cases of Immunoglobulin G4-Related Lung Disease: Focused on Disease ProgressionDong-Kyu Lee0Soo-Youn Ham1Department of Radiology, Korea University Anam Hospital, Korea University College of Medicine, Seoul, KoreaDepartment of Radiology, Kangbuk Samsung Hospital, Seoul, KoreaImmunoglobulin G4 (IgG4)-related lung disease has been actively studied over the past few years. Radiologic findings of IgG4-related lung disease vary among patients, but there are no long-term follow up studies regarding variations in imaging features over the course of disease progression. In two cases with relatively long-term follow up, diverse early and late computed tomography (CT) findings of IgG4-related lung disease are reviewed in this report. In contrast to nodular or diffuse ground-glass opacity, which was predominantly noted in CT scans at earlier stages of disease, honeycombing and traction bronchiectasis were regarded as late radiologic manifestations. Solid nodules might be visible in both early and late stages; however, development of new solid nodules and enlargement of preexisting nodules could occur during disease progression. Interlobular septal thickening and mediastinal/hilar lymphadenopathy were persistent, even in later stages of the disease. These findings might be useful in making an accurate and timely diagnosis of IgG4-related lung disease.https://doi.org/10.3348/jksr.2018.79.5.276igg4lungdiseasecomputed tomographyx-rayprogression
spellingShingle Dong-Kyu Lee
Soo-Youn Ham
Sequential CT Findings in Two Cases of Immunoglobulin G4-Related Lung Disease: Focused on Disease Progression
대한영상의학회지
igg4
lung
disease
computed tomography
x-ray
progression
title Sequential CT Findings in Two Cases of Immunoglobulin G4-Related Lung Disease: Focused on Disease Progression
title_full Sequential CT Findings in Two Cases of Immunoglobulin G4-Related Lung Disease: Focused on Disease Progression
title_fullStr Sequential CT Findings in Two Cases of Immunoglobulin G4-Related Lung Disease: Focused on Disease Progression
title_full_unstemmed Sequential CT Findings in Two Cases of Immunoglobulin G4-Related Lung Disease: Focused on Disease Progression
title_short Sequential CT Findings in Two Cases of Immunoglobulin G4-Related Lung Disease: Focused on Disease Progression
title_sort sequential ct findings in two cases of immunoglobulin g4 related lung disease focused on disease progression
topic igg4
lung
disease
computed tomography
x-ray
progression
url https://doi.org/10.3348/jksr.2018.79.5.276
work_keys_str_mv AT dongkyulee sequentialctfindingsintwocasesofimmunoglobuling4relatedlungdiseasefocusedondiseaseprogression
AT sooyounham sequentialctfindingsintwocasesofimmunoglobuling4relatedlungdiseasefocusedondiseaseprogression