Cutaneous squamous carcinoma in a patient with diabetic foot: an unusual evolution of a frequent complication
After basal cell carcinoma, the cutaneous squamous cell carcinoma (cSCC) is the second most frequent non-melanoma skin cancer worldwide, and, classically, arises from the upper coats of the epidermis of sun-exposed areas or from skin areas constantly exposed to a chronic inflammatory stimulus. The o...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Bioscientifica
2018-07-01
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| Series: | Endocrinology, Diabetes & Metabolism Case Reports |
| Online Access: | https://www.edmcasereports.com/articles/endocrinology-diabetes-and-metabolism-case-reports/10.1530/EDM-18-0065 |
| _version_ | 1818544900283564032 |
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| author | Alessandro Mantovani Ilaria Teobaldi Vincenzo Stoico Fabrizia Perrone Marina Zannoni Luca Cima Massimiliano Bruti Lucia Mingolla Maddalena Trombetta Enzo Bonora |
| author_facet | Alessandro Mantovani Ilaria Teobaldi Vincenzo Stoico Fabrizia Perrone Marina Zannoni Luca Cima Massimiliano Bruti Lucia Mingolla Maddalena Trombetta Enzo Bonora |
| author_sort | Alessandro Mantovani |
| collection | DOAJ |
| description | After basal cell carcinoma, the cutaneous squamous cell carcinoma (cSCC) is the second most frequent non-melanoma skin cancer worldwide, and, classically, arises from the upper coats of the epidermis of sun-exposed areas or from skin areas constantly exposed to a chronic inflammatory stimulus. The occurrence of cSCC seems to be linked to several factors, including exposure to sunlight (or other ultraviolet radiations), immunosuppression, chronic scarring conditions and some familial cancer syndromes. Although the majority of cSCCs are adequately eradicated by surgical excision, a subgroup of cSCC may be linked with an increased risk of recurrence, metastasis and death. The incidence of type 2 diabetes mellitus is constantly increasing worldwide. Importantly, diabetes mellitus is a strong risk factor for cancers (including cutaneous tumors) and is highly related with poor cancer outcomes. At present, in the literature, squamous cell carcinoma developing in association with diabetic foot ulcers has been already reported in some reports; however, additional data are needed to make the clinicians aware of this rare, although possible, complication. Therefore, we herein report an unusual case of an elderly man with T2DM and a positive oncological history, presenting a cSCC involving the skin overlying the first toe of left foot. The growing cSCC appeared approximately 3 years after the appearance of a diabetic ulcer. |
| first_indexed | 2024-12-11T22:54:29Z |
| format | Article |
| id | doaj.art-811b65d71ee343d7af9ab28d51a3ce8d |
| institution | Directory Open Access Journal |
| issn | 2052-0573 2052-0573 |
| language | English |
| last_indexed | 2024-12-11T22:54:29Z |
| publishDate | 2018-07-01 |
| publisher | Bioscientifica |
| record_format | Article |
| series | Endocrinology, Diabetes & Metabolism Case Reports |
| spelling | doaj.art-811b65d71ee343d7af9ab28d51a3ce8d2022-12-22T00:47:17ZengBioscientificaEndocrinology, Diabetes & Metabolism Case Reports2052-05732052-05732018-07-01111510.1530/EDM-18-0065Cutaneous squamous carcinoma in a patient with diabetic foot: an unusual evolution of a frequent complicationAlessandro Mantovani0Ilaria Teobaldi1Vincenzo Stoico2Fabrizia Perrone3Marina Zannoni4Luca Cima5Massimiliano Bruti6Lucia Mingolla7Maddalena Trombetta8Enzo Bonora9Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, University and Azienda Ospedaliera Universitaria Integrata of Verona, Verona, ItalyDivision of Endocrinology, Diabetes and Metabolism, Department of Medicine, University and Azienda Ospedaliera Universitaria Integrata of Verona, Verona, ItalyDivision of Endocrinology, Diabetes and Metabolism, Department of Medicine, University and Azienda Ospedaliera Universitaria Integrata of Verona, Verona, ItalyDivision of Endocrinology, Diabetes and Metabolism, Department of Medicine, University and Azienda Ospedaliera Universitaria Integrata of Verona, Verona, ItalyDivision of Pathology Unit, Department of Diagnostics and Public Health, University and Azienda Ospedaliera Universitaria Integrata of Verona, Verona, ItalyDivision of Pathology Unit, Department of Diagnostics and Public Health, University and Azienda Ospedaliera Universitaria Integrata of Verona, Verona, ItalyDivision of Plastic Surgery, Department of Surgery, University and Azienda Ospedaliera Universitaria Integrata of Verona, Verona, ItalyDivision of Endocrinology, Diabetes and Metabolism, Department of Medicine, University and Azienda Ospedaliera Universitaria Integrata of Verona, Verona, ItalyDivision of Endocrinology, Diabetes and Metabolism, Department of Medicine, University and Azienda Ospedaliera Universitaria Integrata of Verona, Verona, ItalyDivision of Endocrinology, Diabetes and Metabolism, Department of Medicine, University and Azienda Ospedaliera Universitaria Integrata of Verona, Verona, ItalyAfter basal cell carcinoma, the cutaneous squamous cell carcinoma (cSCC) is the second most frequent non-melanoma skin cancer worldwide, and, classically, arises from the upper coats of the epidermis of sun-exposed areas or from skin areas constantly exposed to a chronic inflammatory stimulus. The occurrence of cSCC seems to be linked to several factors, including exposure to sunlight (or other ultraviolet radiations), immunosuppression, chronic scarring conditions and some familial cancer syndromes. Although the majority of cSCCs are adequately eradicated by surgical excision, a subgroup of cSCC may be linked with an increased risk of recurrence, metastasis and death. The incidence of type 2 diabetes mellitus is constantly increasing worldwide. Importantly, diabetes mellitus is a strong risk factor for cancers (including cutaneous tumors) and is highly related with poor cancer outcomes. At present, in the literature, squamous cell carcinoma developing in association with diabetic foot ulcers has been already reported in some reports; however, additional data are needed to make the clinicians aware of this rare, although possible, complication. Therefore, we herein report an unusual case of an elderly man with T2DM and a positive oncological history, presenting a cSCC involving the skin overlying the first toe of left foot. The growing cSCC appeared approximately 3 years after the appearance of a diabetic ulcer.https://www.edmcasereports.com/articles/endocrinology-diabetes-and-metabolism-case-reports/10.1530/EDM-18-0065 |
| spellingShingle | Alessandro Mantovani Ilaria Teobaldi Vincenzo Stoico Fabrizia Perrone Marina Zannoni Luca Cima Massimiliano Bruti Lucia Mingolla Maddalena Trombetta Enzo Bonora Cutaneous squamous carcinoma in a patient with diabetic foot: an unusual evolution of a frequent complication Endocrinology, Diabetes & Metabolism Case Reports |
| title | Cutaneous squamous carcinoma in a patient with diabetic foot: an unusual evolution of a frequent complication |
| title_full | Cutaneous squamous carcinoma in a patient with diabetic foot: an unusual evolution of a frequent complication |
| title_fullStr | Cutaneous squamous carcinoma in a patient with diabetic foot: an unusual evolution of a frequent complication |
| title_full_unstemmed | Cutaneous squamous carcinoma in a patient with diabetic foot: an unusual evolution of a frequent complication |
| title_short | Cutaneous squamous carcinoma in a patient with diabetic foot: an unusual evolution of a frequent complication |
| title_sort | cutaneous squamous carcinoma in a patient with diabetic foot an unusual evolution of a frequent complication |
| url | https://www.edmcasereports.com/articles/endocrinology-diabetes-and-metabolism-case-reports/10.1530/EDM-18-0065 |
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