Insulin resistance and metabolic syndrome are related to non-alcoholic fatty liver disease, but not visceral adiposity index, in severely obese patients

The visceral adiposity index (VAI) is a marker of visceral fat distribution and dysfunction. Visceral adiposity is related to non-alcoholic fatty liver disease (NAFLD); however, there is some controversy regarding the association between VAI and NAFLD. The aim of this study was to analyse the relati...

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Main Authors: Rubén Díez-Rodríguez, María Dolores Ballesteros-Pomar, Alicia Calleja-Fernández, Tomás González-De-Francisco, Luis González-Herráez, Sara Calleja-Antolín, Isidoro Cano-Rodríguez, José Luis Olcoz-Goñi
Format: Article
Language:English
Published: Aran Ediciones 2014-12-01
Series:Revista Espanola de Enfermedades Digestivas
Subjects:
Online Access:http://scielo.isciii.es/scielo.php?script=sci_arttext&pid=S1130-01082014000800004&lng=en&tlng=en
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author Rubén Díez-Rodríguez
María Dolores Ballesteros-Pomar
Alicia Calleja-Fernández
Tomás González-De-Francisco
Luis González-Herráez
Sara Calleja-Antolín
Isidoro Cano-Rodríguez
José Luis Olcoz-Goñi
author_facet Rubén Díez-Rodríguez
María Dolores Ballesteros-Pomar
Alicia Calleja-Fernández
Tomás González-De-Francisco
Luis González-Herráez
Sara Calleja-Antolín
Isidoro Cano-Rodríguez
José Luis Olcoz-Goñi
author_sort Rubén Díez-Rodríguez
collection DOAJ
description The visceral adiposity index (VAI) is a marker of visceral fat distribution and dysfunction. Visceral adiposity is related to non-alcoholic fatty liver disease (NAFLD); however, there is some controversy regarding the association between VAI and NAFLD. The aim of this study was to analyse the relationship between VAI and NAFLD and to describe the related factors in severely obese patients. A total of 139 patients who underwent bariatric surgery were included in this cross-sectional study. Liver biopsy was performed during surgery. Univariate and multivariate analysis were conducted to study the features related to VAI. A univariate analysis was conducted to identify which factors were associated with liver histology. In the univariate analysis, steatosis, liver inflammation, non-alcoholic steatohepatitis (NASH) and fibrosis were associated with VAI. In the multivariate analysis, only HOMA (Beta: 0.06; p < 0.01) and metabolic syndrome (Beta: 1.23; p < 0.01) were related to VAI. HOMA, the presence of metabolic syndrome, and waist circumference (WC) were statistically related to the NAFLD activity score (NAS score): HOMA: 0-2: 5.04; 3-4: 7.83; ≥ 5: 11,32; p < 0.01; MS: 0-2: 37 %; 3-4: 33.3 %; ≥ 5: 76%; p < 0.01; WC: 0-2: 128.7 cm; 3-4: 130.7; ≥ 5: 140.6; p < 0.01). For the prediction of NASH (NAS score ≥ 5), the AUROC curve were 0.71 (CI 95 %: 0.63-0.79) for VAI and 0.7 (CI 95 %: 0.62-0.78) for WC. In conclusion, HOMA, WC and metabolic syndrome are related to liver histology in patients with severe obesity. In the multivariate analysis, VAI was associated with HOMA and metabolic syndrome, but not with liver histology.
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spelling doaj.art-811c3e554bbf44df939b2886c13e1f0a2022-12-21T18:37:41ZengAran EdicionesRevista Espanola de Enfermedades Digestivas1130-01082014-12-011068522528S1130-01082014000800004Insulin resistance and metabolic syndrome are related to non-alcoholic fatty liver disease, but not visceral adiposity index, in severely obese patientsRubén Díez-Rodríguez0María Dolores Ballesteros-Pomar1Alicia Calleja-Fernández2Tomás González-De-Francisco3Luis González-Herráez4Sara Calleja-Antolín5Isidoro Cano-Rodríguez6José Luis Olcoz-Goñi7Complejo Asistencial Universitario LeónComplejo Asistencial Universitario LeónComplejo Asistencial Universitario LeónComplejo Asistencial Universitario LeónComplejo Asistencial Universitario LeónComplejo Asistencial Universitario LeónComplejo Asistencial Universitario LeónComplejo Asistencial Universitario LeónThe visceral adiposity index (VAI) is a marker of visceral fat distribution and dysfunction. Visceral adiposity is related to non-alcoholic fatty liver disease (NAFLD); however, there is some controversy regarding the association between VAI and NAFLD. The aim of this study was to analyse the relationship between VAI and NAFLD and to describe the related factors in severely obese patients. A total of 139 patients who underwent bariatric surgery were included in this cross-sectional study. Liver biopsy was performed during surgery. Univariate and multivariate analysis were conducted to study the features related to VAI. A univariate analysis was conducted to identify which factors were associated with liver histology. In the univariate analysis, steatosis, liver inflammation, non-alcoholic steatohepatitis (NASH) and fibrosis were associated with VAI. In the multivariate analysis, only HOMA (Beta: 0.06; p < 0.01) and metabolic syndrome (Beta: 1.23; p < 0.01) were related to VAI. HOMA, the presence of metabolic syndrome, and waist circumference (WC) were statistically related to the NAFLD activity score (NAS score): HOMA: 0-2: 5.04; 3-4: 7.83; ≥ 5: 11,32; p < 0.01; MS: 0-2: 37 %; 3-4: 33.3 %; ≥ 5: 76%; p < 0.01; WC: 0-2: 128.7 cm; 3-4: 130.7; ≥ 5: 140.6; p < 0.01). For the prediction of NASH (NAS score ≥ 5), the AUROC curve were 0.71 (CI 95 %: 0.63-0.79) for VAI and 0.7 (CI 95 %: 0.62-0.78) for WC. In conclusion, HOMA, WC and metabolic syndrome are related to liver histology in patients with severe obesity. In the multivariate analysis, VAI was associated with HOMA and metabolic syndrome, but not with liver histology.http://scielo.isciii.es/scielo.php?script=sci_arttext&pid=S1130-01082014000800004&lng=en&tlng=enAbdominal obesityNon-alcoholic steatohepatitisFatty liver
spellingShingle Rubén Díez-Rodríguez
María Dolores Ballesteros-Pomar
Alicia Calleja-Fernández
Tomás González-De-Francisco
Luis González-Herráez
Sara Calleja-Antolín
Isidoro Cano-Rodríguez
José Luis Olcoz-Goñi
Insulin resistance and metabolic syndrome are related to non-alcoholic fatty liver disease, but not visceral adiposity index, in severely obese patients
Revista Espanola de Enfermedades Digestivas
Abdominal obesity
Non-alcoholic steatohepatitis
Fatty liver
title Insulin resistance and metabolic syndrome are related to non-alcoholic fatty liver disease, but not visceral adiposity index, in severely obese patients
title_full Insulin resistance and metabolic syndrome are related to non-alcoholic fatty liver disease, but not visceral adiposity index, in severely obese patients
title_fullStr Insulin resistance and metabolic syndrome are related to non-alcoholic fatty liver disease, but not visceral adiposity index, in severely obese patients
title_full_unstemmed Insulin resistance and metabolic syndrome are related to non-alcoholic fatty liver disease, but not visceral adiposity index, in severely obese patients
title_short Insulin resistance and metabolic syndrome are related to non-alcoholic fatty liver disease, but not visceral adiposity index, in severely obese patients
title_sort insulin resistance and metabolic syndrome are related to non alcoholic fatty liver disease but not visceral adiposity index in severely obese patients
topic Abdominal obesity
Non-alcoholic steatohepatitis
Fatty liver
url http://scielo.isciii.es/scielo.php?script=sci_arttext&pid=S1130-01082014000800004&lng=en&tlng=en
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