Potential Alternative Strategy against Drug Resistant Tuberculosis: A Proteomics Prospect
Mycobacterium tuberculosis is one of the deadliest human pathogen of the tuberculosis diseases. Drug resistance leads to emergence of multidrug-resistant and extremely drug resistant strains of M. tuberculosis. Apart from principal targets of resistance, many explanations have been proposed for drug...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2018-05-01
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| Series: | Proteomes |
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| Online Access: | http://www.mdpi.com/2227-7382/6/2/26 |
| _version_ | 1811263229898260480 |
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| author | Divakar Sharma Deepa Bisht Asad U. Khan |
| author_facet | Divakar Sharma Deepa Bisht Asad U. Khan |
| author_sort | Divakar Sharma |
| collection | DOAJ |
| description | Mycobacterium tuberculosis is one of the deadliest human pathogen of the tuberculosis diseases. Drug resistance leads to emergence of multidrug-resistant and extremely drug resistant strains of M. tuberculosis. Apart from principal targets of resistance, many explanations have been proposed for drug resistance but some resistance mechanisms are still unknown. Recently approved line probe assay (LPA) diagnostics for detecting the resistance to first and second line drugs are unable to diagnose the drug resistance in M. tuberculosis isolates which do not have the mutations in particular genes responsible for resistance. Proteomics and bioinformatic tools emerged as direct approaches for identification and characterization of novel proteins which are directly and indirectly involved in drug resistance that could be used as potential targets in future. In future, these novel targets might reveal new mechanism of resistance and can be used in diagnostics or as drug targets. |
| first_indexed | 2024-04-12T19:40:58Z |
| format | Article |
| id | doaj.art-811d24929025438d8c089b9ab0b1b7c9 |
| institution | Directory Open Access Journal |
| issn | 2227-7382 |
| language | English |
| last_indexed | 2024-04-12T19:40:58Z |
| publishDate | 2018-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Proteomes |
| spelling | doaj.art-811d24929025438d8c089b9ab0b1b7c92022-12-22T03:19:05ZengMDPI AGProteomes2227-73822018-05-01622610.3390/proteomes6020026proteomes6020026Potential Alternative Strategy against Drug Resistant Tuberculosis: A Proteomics ProspectDivakar Sharma0Deepa Bisht1Asad U. Khan2Department of Biochemistry, National JALMA Institute for Leprosy and Other Mycobacterial Diseases, Tajganj, Agra 282004, IndiaDepartment of Biochemistry, National JALMA Institute for Leprosy and Other Mycobacterial Diseases, Tajganj, Agra 282004, IndiaMedical Microbiology and Molecular Biology Laboratory, Interdisciplinary Biotechnology Unit, Aligarh Muslim University, Aligarh 202002, IndiaMycobacterium tuberculosis is one of the deadliest human pathogen of the tuberculosis diseases. Drug resistance leads to emergence of multidrug-resistant and extremely drug resistant strains of M. tuberculosis. Apart from principal targets of resistance, many explanations have been proposed for drug resistance but some resistance mechanisms are still unknown. Recently approved line probe assay (LPA) diagnostics for detecting the resistance to first and second line drugs are unable to diagnose the drug resistance in M. tuberculosis isolates which do not have the mutations in particular genes responsible for resistance. Proteomics and bioinformatic tools emerged as direct approaches for identification and characterization of novel proteins which are directly and indirectly involved in drug resistance that could be used as potential targets in future. In future, these novel targets might reveal new mechanism of resistance and can be used in diagnostics or as drug targets.http://www.mdpi.com/2227-7382/6/2/26tuberculosisinfectious diseasesdrug resistanceproteomicsalternative strategies |
| spellingShingle | Divakar Sharma Deepa Bisht Asad U. Khan Potential Alternative Strategy against Drug Resistant Tuberculosis: A Proteomics Prospect Proteomes tuberculosis infectious diseases drug resistance proteomics alternative strategies |
| title | Potential Alternative Strategy against Drug Resistant Tuberculosis: A Proteomics Prospect |
| title_full | Potential Alternative Strategy against Drug Resistant Tuberculosis: A Proteomics Prospect |
| title_fullStr | Potential Alternative Strategy against Drug Resistant Tuberculosis: A Proteomics Prospect |
| title_full_unstemmed | Potential Alternative Strategy against Drug Resistant Tuberculosis: A Proteomics Prospect |
| title_short | Potential Alternative Strategy against Drug Resistant Tuberculosis: A Proteomics Prospect |
| title_sort | potential alternative strategy against drug resistant tuberculosis a proteomics prospect |
| topic | tuberculosis infectious diseases drug resistance proteomics alternative strategies |
| url | http://www.mdpi.com/2227-7382/6/2/26 |
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