The Preventive Role of mRNA Vaccines in Reducing Death among Moderate Omicron-Infected Patients: A Follow-Up Study
Very few studies have been conducted to assess the potential preventive role of vaccines, particularly mRNA vaccines, in the improvement of survival among moderate and severe hospitalized patients with COVID-19. After community-acquired outbreaks of the Omicron variant from 18 March until 31 May 202...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-11-01
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| Series: | Viruses |
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| Online Access: | https://www.mdpi.com/1999-4915/14/12/2622 |
| _version_ | 1797454974748196864 |
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| author | Amy Ming-Fang Yen Sam Li-Sheng Chen Chen-Yang Hsu Tony Hsiu-Hsi Chen |
| author_facet | Amy Ming-Fang Yen Sam Li-Sheng Chen Chen-Yang Hsu Tony Hsiu-Hsi Chen |
| author_sort | Amy Ming-Fang Yen |
| collection | DOAJ |
| description | Very few studies have been conducted to assess the potential preventive role of vaccines, particularly mRNA vaccines, in the improvement of survival among moderate and severe hospitalized patients with COVID-19. After community-acquired outbreaks of the Omicron variant from 18 March until 31 May 2022, occurred in Taiwan, this retrospective cohort of 4090 moderate and 1378 severe patients admitted to hospital was classified according to whether they were administered an mRNA-based vaccine, and followed up to ascertain rates of death in both the vaccinated (≥2 doses) and unvaccinated (no or 1 dose) groups. The age-adjusted hazard ratio (aHR) of less than 1 was used to assess the preventive role of mRNA vaccines in reducing deaths among moderate and severe Omicron-infected patients. Survival was statistically significantly better for the ≥2 dose jab group (aHR, 0.75, 95% confidence interval [CI], 0.60 to 0.94) and even higher among those who had received a booster jab (aHR, 0.71; 95% CI, 0.55 to 0.91) compared with the unvaccinated group among moderate patients, but not among severe patients. In conclusion, unveiling the role of mRNA vaccines in preventing moderate but not severe COVID-19 patients from death provides new insights into how mRNA vaccines play a role in the pathway leading to a severe outcome due to Omicron COVID-19. |
| first_indexed | 2024-03-09T15:44:52Z |
| format | Article |
| id | doaj.art-811dcfb2d8044a7e87d21c9c28a62310 |
| institution | Directory Open Access Journal |
| issn | 1999-4915 |
| language | English |
| last_indexed | 2024-03-09T15:44:52Z |
| publishDate | 2022-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj.art-811dcfb2d8044a7e87d21c9c28a623102023-11-24T18:36:42ZengMDPI AGViruses1999-49152022-11-011412262210.3390/v14122622The Preventive Role of mRNA Vaccines in Reducing Death among Moderate Omicron-Infected Patients: A Follow-Up StudyAmy Ming-Fang Yen0Sam Li-Sheng Chen1Chen-Yang Hsu2Tony Hsiu-Hsi Chen3School of Oral Hygiene, College of Oral Medicine, Taipei Medical University, Taipei City 110, TaiwanSchool of Oral Hygiene, College of Oral Medicine, Taipei Medical University, Taipei City 110, TaiwanDaichung Hospital, Miaoli County 350, TaiwanInstitute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei City 110, TaiwanVery few studies have been conducted to assess the potential preventive role of vaccines, particularly mRNA vaccines, in the improvement of survival among moderate and severe hospitalized patients with COVID-19. After community-acquired outbreaks of the Omicron variant from 18 March until 31 May 2022, occurred in Taiwan, this retrospective cohort of 4090 moderate and 1378 severe patients admitted to hospital was classified according to whether they were administered an mRNA-based vaccine, and followed up to ascertain rates of death in both the vaccinated (≥2 doses) and unvaccinated (no or 1 dose) groups. The age-adjusted hazard ratio (aHR) of less than 1 was used to assess the preventive role of mRNA vaccines in reducing deaths among moderate and severe Omicron-infected patients. Survival was statistically significantly better for the ≥2 dose jab group (aHR, 0.75, 95% confidence interval [CI], 0.60 to 0.94) and even higher among those who had received a booster jab (aHR, 0.71; 95% CI, 0.55 to 0.91) compared with the unvaccinated group among moderate patients, but not among severe patients. In conclusion, unveiling the role of mRNA vaccines in preventing moderate but not severe COVID-19 patients from death provides new insights into how mRNA vaccines play a role in the pathway leading to a severe outcome due to Omicron COVID-19.https://www.mdpi.com/1999-4915/14/12/2622COVID-19mRNAOmicronsurvivalpreventive effect |
| spellingShingle | Amy Ming-Fang Yen Sam Li-Sheng Chen Chen-Yang Hsu Tony Hsiu-Hsi Chen The Preventive Role of mRNA Vaccines in Reducing Death among Moderate Omicron-Infected Patients: A Follow-Up Study Viruses COVID-19 mRNA Omicron survival preventive effect |
| title | The Preventive Role of mRNA Vaccines in Reducing Death among Moderate Omicron-Infected Patients: A Follow-Up Study |
| title_full | The Preventive Role of mRNA Vaccines in Reducing Death among Moderate Omicron-Infected Patients: A Follow-Up Study |
| title_fullStr | The Preventive Role of mRNA Vaccines in Reducing Death among Moderate Omicron-Infected Patients: A Follow-Up Study |
| title_full_unstemmed | The Preventive Role of mRNA Vaccines in Reducing Death among Moderate Omicron-Infected Patients: A Follow-Up Study |
| title_short | The Preventive Role of mRNA Vaccines in Reducing Death among Moderate Omicron-Infected Patients: A Follow-Up Study |
| title_sort | preventive role of mrna vaccines in reducing death among moderate omicron infected patients a follow up study |
| topic | COVID-19 mRNA Omicron survival preventive effect |
| url | https://www.mdpi.com/1999-4915/14/12/2622 |
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