Systematic Review of Risk Factors Assessed in Predictive Scoring Tools for Drug-Related Problems in Inpatients
Drug-related problems (DRP, defined as adverse drug events/reactions and medication errors) are a common threat for patient safety. With the aim to aid improved allocation of specialist resources and to improve detection and prevention of DRP, numerous predictive scoring tools have been proposed. Th...
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| Format: | Article |
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MDPI AG
2022-09-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/11/17/5185 |
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| author | Lea Jung-Poppe Hagen Fabian Nicolaus Anna Roggenhofer Anna Altenbuchner Harald Dormann Barbara Pfistermeister Renke Maas |
| author_facet | Lea Jung-Poppe Hagen Fabian Nicolaus Anna Roggenhofer Anna Altenbuchner Harald Dormann Barbara Pfistermeister Renke Maas |
| author_sort | Lea Jung-Poppe |
| collection | DOAJ |
| description | Drug-related problems (DRP, defined as adverse drug events/reactions and medication errors) are a common threat for patient safety. With the aim to aid improved allocation of specialist resources and to improve detection and prevention of DRP, numerous predictive scoring tools have been proposed. The external validation and evidence for the transferability of these tools still faces limitations. However, the proposed scoring tools include partly overlapping sets of similar factors, which may allow a new approach to estimate the external usability and validity of individual risk factors. Therefore, we conducted this systematic review and analysis. We identified 14 key studies that assessed 844 candidate risk factors for inclusion into predictive scoring tools. After consolidation to account for overlapping terminology and variable definitions, we assessed each risk factor in the number of studies it was assessed, and, if it was found to be a significant predictor of DRP, whether it was included in a final scoring tool. The latter included intake of ≥ 8 drugs, drugs of the Anatomical Therapeutic Chemical (ATC) class N, ≥1 comorbidity, an estimated glomerular filtration rate (eGFR) <30 mL/min and age ≥60 years. The methodological approach and the individual risk factors presented in this review may provide a new starting point for improved risk assessment. |
| first_indexed | 2024-03-10T01:38:32Z |
| format | Article |
| id | doaj.art-81239f80751042f9b9394fbee785df2b |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-10T01:38:32Z |
| publishDate | 2022-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-81239f80751042f9b9394fbee785df2b2023-11-23T13:29:10ZengMDPI AGJournal of Clinical Medicine2077-03832022-09-011117518510.3390/jcm11175185Systematic Review of Risk Factors Assessed in Predictive Scoring Tools for Drug-Related Problems in InpatientsLea Jung-Poppe0Hagen Fabian Nicolaus1Anna Roggenhofer2Anna Altenbuchner3Harald Dormann4Barbara Pfistermeister5Renke Maas6Institute of Experimental and Clinical Pharmacology and Toxicology, Friedrich-Alexander-Universität Erlangen-Nürnberg, 91054 Erlangen, GermanyInstitute of Experimental and Clinical Pharmacology and Toxicology, Friedrich-Alexander-Universität Erlangen-Nürnberg, 91054 Erlangen, GermanyInstitute of Experimental and Clinical Pharmacology and Toxicology, Friedrich-Alexander-Universität Erlangen-Nürnberg, 91054 Erlangen, GermanyInstitute of Experimental and Clinical Pharmacology and Toxicology, Friedrich-Alexander-Universität Erlangen-Nürnberg, 91054 Erlangen, GermanyCentral Emergency Department, Fürth Hospital, 90766 Fürth, GermanyHospital Pharmacy, Fürth Hospital, 90766 Fürth, GermanyInstitute of Experimental and Clinical Pharmacology and Toxicology, Friedrich-Alexander-Universität Erlangen-Nürnberg, 91054 Erlangen, GermanyDrug-related problems (DRP, defined as adverse drug events/reactions and medication errors) are a common threat for patient safety. With the aim to aid improved allocation of specialist resources and to improve detection and prevention of DRP, numerous predictive scoring tools have been proposed. The external validation and evidence for the transferability of these tools still faces limitations. However, the proposed scoring tools include partly overlapping sets of similar factors, which may allow a new approach to estimate the external usability and validity of individual risk factors. Therefore, we conducted this systematic review and analysis. We identified 14 key studies that assessed 844 candidate risk factors for inclusion into predictive scoring tools. After consolidation to account for overlapping terminology and variable definitions, we assessed each risk factor in the number of studies it was assessed, and, if it was found to be a significant predictor of DRP, whether it was included in a final scoring tool. The latter included intake of ≥ 8 drugs, drugs of the Anatomical Therapeutic Chemical (ATC) class N, ≥1 comorbidity, an estimated glomerular filtration rate (eGFR) <30 mL/min and age ≥60 years. The methodological approach and the individual risk factors presented in this review may provide a new starting point for improved risk assessment.https://www.mdpi.com/2077-0383/11/17/5185risk factorsdrug-related problemsadverse drug eventsadverse drug reactionsmedication errorspredictive scoring tool |
| spellingShingle | Lea Jung-Poppe Hagen Fabian Nicolaus Anna Roggenhofer Anna Altenbuchner Harald Dormann Barbara Pfistermeister Renke Maas Systematic Review of Risk Factors Assessed in Predictive Scoring Tools for Drug-Related Problems in Inpatients Journal of Clinical Medicine risk factors drug-related problems adverse drug events adverse drug reactions medication errors predictive scoring tool |
| title | Systematic Review of Risk Factors Assessed in Predictive Scoring Tools for Drug-Related Problems in Inpatients |
| title_full | Systematic Review of Risk Factors Assessed in Predictive Scoring Tools for Drug-Related Problems in Inpatients |
| title_fullStr | Systematic Review of Risk Factors Assessed in Predictive Scoring Tools for Drug-Related Problems in Inpatients |
| title_full_unstemmed | Systematic Review of Risk Factors Assessed in Predictive Scoring Tools for Drug-Related Problems in Inpatients |
| title_short | Systematic Review of Risk Factors Assessed in Predictive Scoring Tools for Drug-Related Problems in Inpatients |
| title_sort | systematic review of risk factors assessed in predictive scoring tools for drug related problems in inpatients |
| topic | risk factors drug-related problems adverse drug events adverse drug reactions medication errors predictive scoring tool |
| url | https://www.mdpi.com/2077-0383/11/17/5185 |
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