The Karachi intracranial stenosis study (KISS) Protocol: An urban multicenter case-control investigation reporting the clinical, radiologic and biochemical associations of intracranial stenosis in Pakistan
<p>Abstract</p> <p>Background</p> <p>Intracranial stenosis is the most common cause of stroke among Asians. It has a poor prognosis with a high rate of recurrence. No effective medical or surgical treatment modality has been developed for the treatment of stroke due to...
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2009-07-01
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| Series: | BMC Neurology |
| Online Access: | http://www.biomedcentral.com/1471-2377/9/31 |
| _version_ | 1818664354571091968 |
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| author | Makki Karim Sheikh Niaz Mahmood Khalid Ahmed Naveeduddin Khan Farrukh Naz Sobia Yameen Madiha Samuel Maria Shah Nabi Bansari Lajpat Waheed Shahan Saleem Uzma Alam Syed Hashmat Fahad Iqbal Naved Murtaza Muhammed Zaidi Moazzam Rasheed Asif Junaidi Babar Taj Fawad Kamal Ayeesha Ahmed Muhammad Memon Abdul Wasay Mohammad Syed Nadir Khealani Bhojo Frossard Philippe M Saleheen Danish |
| author_facet | Makki Karim Sheikh Niaz Mahmood Khalid Ahmed Naveeduddin Khan Farrukh Naz Sobia Yameen Madiha Samuel Maria Shah Nabi Bansari Lajpat Waheed Shahan Saleem Uzma Alam Syed Hashmat Fahad Iqbal Naved Murtaza Muhammed Zaidi Moazzam Rasheed Asif Junaidi Babar Taj Fawad Kamal Ayeesha Ahmed Muhammad Memon Abdul Wasay Mohammad Syed Nadir Khealani Bhojo Frossard Philippe M Saleheen Danish |
| author_sort | Makki Karim |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>Intracranial stenosis is the most common cause of stroke among Asians. It has a poor prognosis with a high rate of recurrence. No effective medical or surgical treatment modality has been developed for the treatment of stroke due to intracranial stenosis. We aim to identify risk factors and biomarkers for intracranial stenosis and to develop techniques such as use of transcranial doppler to help diagnose intracranial stenosis in a cost-effective manner.</p> <p>Methods/Design</p> <p>The Karachi Intracranial Stenosis Study (KISS) is a prospective, observational, case-control study to describe the clinical features and determine the risk factors of patients with stroke due to intracranial stenosis and compare them to those with stroke due to other etiologies as well as to unaffected individuals. We plan to recruit 200 patients with stroke due to intracranial stenosis and two control groups each of 150 matched individuals. The first set of controls will include patients with ischemic stroke that is due to other atherosclerotic mechanisms specifically lacunar and cardioembolic strokes. The second group will consist of stroke free individuals. Standardized interviews will be conducted to determine demographic, medical, social, and behavioral variables along with baseline medications. Mandatory procedures for inclusion in the study are clinical confirmation of stroke by a healthcare professional within 72 hours of onset, 12 lead electrocardiogram, and neuroimaging. In addition, lipid profile, serum glucose, creatinine and HbA<sub>1C </sub>will be measured in all participants. Ancillary tests will include carotid ultrasound, transcranial doppler and magnetic resonance or computed tomography angiogram to rule out concurrent carotid disease. Echocardiogram and other additional investigations will be performed at these centers at the discretion of the regional physicians.</p> <p>Discussion</p> <p>The results of this study will help inform locally relevant clinical guidelines and effective public health and individual interventions.</p> |
| first_indexed | 2024-12-17T05:31:25Z |
| format | Article |
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| institution | Directory Open Access Journal |
| issn | 1471-2377 |
| language | English |
| last_indexed | 2024-12-17T05:31:25Z |
| publishDate | 2009-07-01 |
| publisher | BMC |
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| series | BMC Neurology |
| spelling | doaj.art-812442af16844728874a5493498711022022-12-21T22:01:43ZengBMCBMC Neurology1471-23772009-07-01913110.1186/1471-2377-9-31The Karachi intracranial stenosis study (KISS) Protocol: An urban multicenter case-control investigation reporting the clinical, radiologic and biochemical associations of intracranial stenosis in PakistanMakki KarimSheikh NiazMahmood KhalidAhmed NaveeduddinKhan FarrukhNaz SobiaYameen MadihaSamuel MariaShah NabiBansari LajpatWaheed ShahanSaleem UzmaAlam SyedHashmat FahadIqbal NavedMurtaza MuhammedZaidi MoazzamRasheed AsifJunaidi BabarTaj FawadKamal AyeeshaAhmed MuhammadMemon AbdulWasay MohammadSyed NadirKhealani BhojoFrossard Philippe MSaleheen Danish<p>Abstract</p> <p>Background</p> <p>Intracranial stenosis is the most common cause of stroke among Asians. It has a poor prognosis with a high rate of recurrence. No effective medical or surgical treatment modality has been developed for the treatment of stroke due to intracranial stenosis. We aim to identify risk factors and biomarkers for intracranial stenosis and to develop techniques such as use of transcranial doppler to help diagnose intracranial stenosis in a cost-effective manner.</p> <p>Methods/Design</p> <p>The Karachi Intracranial Stenosis Study (KISS) is a prospective, observational, case-control study to describe the clinical features and determine the risk factors of patients with stroke due to intracranial stenosis and compare them to those with stroke due to other etiologies as well as to unaffected individuals. We plan to recruit 200 patients with stroke due to intracranial stenosis and two control groups each of 150 matched individuals. The first set of controls will include patients with ischemic stroke that is due to other atherosclerotic mechanisms specifically lacunar and cardioembolic strokes. The second group will consist of stroke free individuals. Standardized interviews will be conducted to determine demographic, medical, social, and behavioral variables along with baseline medications. Mandatory procedures for inclusion in the study are clinical confirmation of stroke by a healthcare professional within 72 hours of onset, 12 lead electrocardiogram, and neuroimaging. In addition, lipid profile, serum glucose, creatinine and HbA<sub>1C </sub>will be measured in all participants. Ancillary tests will include carotid ultrasound, transcranial doppler and magnetic resonance or computed tomography angiogram to rule out concurrent carotid disease. Echocardiogram and other additional investigations will be performed at these centers at the discretion of the regional physicians.</p> <p>Discussion</p> <p>The results of this study will help inform locally relevant clinical guidelines and effective public health and individual interventions.</p>http://www.biomedcentral.com/1471-2377/9/31 |
| spellingShingle | Makki Karim Sheikh Niaz Mahmood Khalid Ahmed Naveeduddin Khan Farrukh Naz Sobia Yameen Madiha Samuel Maria Shah Nabi Bansari Lajpat Waheed Shahan Saleem Uzma Alam Syed Hashmat Fahad Iqbal Naved Murtaza Muhammed Zaidi Moazzam Rasheed Asif Junaidi Babar Taj Fawad Kamal Ayeesha Ahmed Muhammad Memon Abdul Wasay Mohammad Syed Nadir Khealani Bhojo Frossard Philippe M Saleheen Danish The Karachi intracranial stenosis study (KISS) Protocol: An urban multicenter case-control investigation reporting the clinical, radiologic and biochemical associations of intracranial stenosis in Pakistan BMC Neurology |
| title | The Karachi intracranial stenosis study (KISS) Protocol: An urban multicenter case-control investigation reporting the clinical, radiologic and biochemical associations of intracranial stenosis in Pakistan |
| title_full | The Karachi intracranial stenosis study (KISS) Protocol: An urban multicenter case-control investigation reporting the clinical, radiologic and biochemical associations of intracranial stenosis in Pakistan |
| title_fullStr | The Karachi intracranial stenosis study (KISS) Protocol: An urban multicenter case-control investigation reporting the clinical, radiologic and biochemical associations of intracranial stenosis in Pakistan |
| title_full_unstemmed | The Karachi intracranial stenosis study (KISS) Protocol: An urban multicenter case-control investigation reporting the clinical, radiologic and biochemical associations of intracranial stenosis in Pakistan |
| title_short | The Karachi intracranial stenosis study (KISS) Protocol: An urban multicenter case-control investigation reporting the clinical, radiologic and biochemical associations of intracranial stenosis in Pakistan |
| title_sort | karachi intracranial stenosis study kiss protocol an urban multicenter case control investigation reporting the clinical radiologic and biochemical associations of intracranial stenosis in pakistan |
| url | http://www.biomedcentral.com/1471-2377/9/31 |
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