Gender as an independent prognostic factor in small-cell lung cancer: Inha Lung Cancer Cohort study using propensity score matching.
<h4>Introduction</h4>The prognostic relevance of gender is undetermined in patients with small-cell lung cancer (SCLC). Therefore, we investigated whether gender is a prognostic factor in a SCLC cohort after controlling for confounding factors.<h4>Materials and methods</h4>Fi...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2018-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0208492 |
| _version_ | 1818398652712878080 |
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| author | Jun Hyeok Lim Jeong-Seon Ryu Jae Hoon Kim Hyun-Jung Kim DaeHyung Lee |
| author_facet | Jun Hyeok Lim Jeong-Seon Ryu Jae Hoon Kim Hyun-Jung Kim DaeHyung Lee |
| author_sort | Jun Hyeok Lim |
| collection | DOAJ |
| description | <h4>Introduction</h4>The prognostic relevance of gender is undetermined in patients with small-cell lung cancer (SCLC). Therefore, we investigated whether gender is a prognostic factor in a SCLC cohort after controlling for confounding factors.<h4>Materials and methods</h4>Fifteen prognostic factors were classified into four groups (patient, stage migration, tumor, and treatment). The prognostic relevance of gender was evaluated using propensity score matching, Cox proportional hazards regression, and stepwise fashion adjustments.<h4>Results</h4>Of 591 patients with SCLC, 88 were women (14.9%). Women were more likely than men to have no history of smoking (48.9% vs. 2.0%, P < 0.001) and limited disease (48.9% vs. 37.8%, P = 0.050). Women had less progressive disease in M stage than men (52.3% vs. 62.8%, P = 0.031). Women had better survival than men in the entire cohort (median survival times [MSTs] and 95% confidence intervals [CIs]: 9.7 months and 7.8-11.6 for women, 8.0 months and 7.0-8.9 for men, log-rank P = 0.034) and in the matched cohort (MSTs and 95% CIs: 8.8 months and 5.8-11.8 for women, 5.9 months and 4.5-7.4 for men, log-rank P = 0.013). Female gender was a prognostic factor predicting better survival, even after stepwise and full adjustment with all prognostic variables (adjusted hazard ratios and 95% CIs: 0.51 and 0.34-0.77, P = 0.001 for entire cohort, 0.42 and 0.24-0.75, P = 0.003 for matched cohort).<h4>Conclusions</h4>Our results confirmed that gender is an independent prognostic factor in patients with SCLC. |
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| id | doaj.art-81279d3ebc064ce595e24a9596caaeef |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-14T07:08:12Z |
| publishDate | 2018-01-01 |
| publisher | Public Library of Science (PLoS) |
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| series | PLoS ONE |
| spelling | doaj.art-81279d3ebc064ce595e24a9596caaeef2022-12-21T23:12:03ZengPublic Library of Science (PLoS)PLoS ONE1932-62032018-01-011312e020849210.1371/journal.pone.0208492Gender as an independent prognostic factor in small-cell lung cancer: Inha Lung Cancer Cohort study using propensity score matching.Jun Hyeok LimJeong-Seon RyuJae Hoon KimHyun-Jung KimDaeHyung Lee<h4>Introduction</h4>The prognostic relevance of gender is undetermined in patients with small-cell lung cancer (SCLC). Therefore, we investigated whether gender is a prognostic factor in a SCLC cohort after controlling for confounding factors.<h4>Materials and methods</h4>Fifteen prognostic factors were classified into four groups (patient, stage migration, tumor, and treatment). The prognostic relevance of gender was evaluated using propensity score matching, Cox proportional hazards regression, and stepwise fashion adjustments.<h4>Results</h4>Of 591 patients with SCLC, 88 were women (14.9%). Women were more likely than men to have no history of smoking (48.9% vs. 2.0%, P < 0.001) and limited disease (48.9% vs. 37.8%, P = 0.050). Women had less progressive disease in M stage than men (52.3% vs. 62.8%, P = 0.031). Women had better survival than men in the entire cohort (median survival times [MSTs] and 95% confidence intervals [CIs]: 9.7 months and 7.8-11.6 for women, 8.0 months and 7.0-8.9 for men, log-rank P = 0.034) and in the matched cohort (MSTs and 95% CIs: 8.8 months and 5.8-11.8 for women, 5.9 months and 4.5-7.4 for men, log-rank P = 0.013). Female gender was a prognostic factor predicting better survival, even after stepwise and full adjustment with all prognostic variables (adjusted hazard ratios and 95% CIs: 0.51 and 0.34-0.77, P = 0.001 for entire cohort, 0.42 and 0.24-0.75, P = 0.003 for matched cohort).<h4>Conclusions</h4>Our results confirmed that gender is an independent prognostic factor in patients with SCLC.https://doi.org/10.1371/journal.pone.0208492 |
| spellingShingle | Jun Hyeok Lim Jeong-Seon Ryu Jae Hoon Kim Hyun-Jung Kim DaeHyung Lee Gender as an independent prognostic factor in small-cell lung cancer: Inha Lung Cancer Cohort study using propensity score matching. PLoS ONE |
| title | Gender as an independent prognostic factor in small-cell lung cancer: Inha Lung Cancer Cohort study using propensity score matching. |
| title_full | Gender as an independent prognostic factor in small-cell lung cancer: Inha Lung Cancer Cohort study using propensity score matching. |
| title_fullStr | Gender as an independent prognostic factor in small-cell lung cancer: Inha Lung Cancer Cohort study using propensity score matching. |
| title_full_unstemmed | Gender as an independent prognostic factor in small-cell lung cancer: Inha Lung Cancer Cohort study using propensity score matching. |
| title_short | Gender as an independent prognostic factor in small-cell lung cancer: Inha Lung Cancer Cohort study using propensity score matching. |
| title_sort | gender as an independent prognostic factor in small cell lung cancer inha lung cancer cohort study using propensity score matching |
| url | https://doi.org/10.1371/journal.pone.0208492 |
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