Systems-based approaches for investigation of inter-tissue communication[S]
Secreted proteins serve as crucial mediators of many physiology processes, and beginning with the discovery of insulin, studies have revealed numerous context-specific regulatory networks across various cell types. Here, we review “omics” approaches to deconvolute the complex milieu of proteins that...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2019-03-01
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| Series: | Journal of Lipid Research |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0022227520326079 |
| _version_ | 1818647967406489600 |
|---|---|
| author | Marcus M. Seldin Aldons J. Lusis |
| author_facet | Marcus M. Seldin Aldons J. Lusis |
| author_sort | Marcus M. Seldin |
| collection | DOAJ |
| description | Secreted proteins serve as crucial mediators of many physiology processes, and beginning with the discovery of insulin, studies have revealed numerous context-specific regulatory networks across various cell types. Here, we review “omics” approaches to deconvolute the complex milieu of proteins that are released from the cell. We emphasize a novel “systems genetics” approach our laboratory has developed to investigate mechanisms of tissue-tissue communication using population-based datasets. Finally, we highlight potential future directions for these studies, discuss several caveats, and propose new ways to investigate modes of endocrine communication. |
| first_indexed | 2024-12-17T01:10:57Z |
| format | Article |
| id | doaj.art-81280f14496a43b2b1c41662ac95b92c |
| institution | Directory Open Access Journal |
| issn | 0022-2275 |
| language | English |
| last_indexed | 2024-12-17T01:10:57Z |
| publishDate | 2019-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Lipid Research |
| spelling | doaj.art-81280f14496a43b2b1c41662ac95b92c2022-12-21T22:09:09ZengElsevierJournal of Lipid Research0022-22752019-03-01603450455Systems-based approaches for investigation of inter-tissue communication[S]Marcus M. Seldin0Aldons J. Lusis1Departments of Medicine, University of California, Los Angeles, Los Angeles, CA 90095Departments of Medicine, University of California, Los Angeles, Los Angeles, CA 90095; Human Genetics University of California, Los Angeles, Los Angeles, CA 90095; Microbiology, Immunology, and Molecular Genetics University of California, Los Angeles, Los Angeles, CA 90095; To whom correspondence should be addressed.Secreted proteins serve as crucial mediators of many physiology processes, and beginning with the discovery of insulin, studies have revealed numerous context-specific regulatory networks across various cell types. Here, we review “omics” approaches to deconvolute the complex milieu of proteins that are released from the cell. We emphasize a novel “systems genetics” approach our laboratory has developed to investigate mechanisms of tissue-tissue communication using population-based datasets. Finally, we highlight potential future directions for these studies, discuss several caveats, and propose new ways to investigate modes of endocrine communication.http://www.sciencedirect.com/science/article/pii/S0022227520326079cytokinesdiabetesgeneticshormonesreceptors/hormone |
| spellingShingle | Marcus M. Seldin Aldons J. Lusis Systems-based approaches for investigation of inter-tissue communication[S] Journal of Lipid Research cytokines diabetes genetics hormones receptors/hormone |
| title | Systems-based approaches for investigation of inter-tissue communication[S] |
| title_full | Systems-based approaches for investigation of inter-tissue communication[S] |
| title_fullStr | Systems-based approaches for investigation of inter-tissue communication[S] |
| title_full_unstemmed | Systems-based approaches for investigation of inter-tissue communication[S] |
| title_short | Systems-based approaches for investigation of inter-tissue communication[S] |
| title_sort | systems based approaches for investigation of inter tissue communication s |
| topic | cytokines diabetes genetics hormones receptors/hormone |
| url | http://www.sciencedirect.com/science/article/pii/S0022227520326079 |
| work_keys_str_mv | AT marcusmseldin systemsbasedapproachesforinvestigationofintertissuecommunications AT aldonsjlusis systemsbasedapproachesforinvestigationofintertissuecommunications |