Severity of atopic dermatitis and Ascaris lumbricoides infection: an evaluation of CCR4+ and CXCR3+ helper T cell frequency
INTRODUCTION: Ascaris lumbricoides-infected patients present lower prevalence of severe atopic dermatitis. METHODS: Peripheral blood of infected children with atopic dermatitis was assessed by flow cytometry of the frequency of Th1 and Th2 cells through the expression of CXCR3 and CCR4 chemokine rec...
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| Format: | Article |
| Language: | English |
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Sociedade Brasileira de Medicina Tropical (SBMT)
2012-12-01
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| Series: | Revista da Sociedade Brasileira de Medicina Tropical |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822012000600021&lng=en&tlng=en |
| _version_ | 1811257756069396480 |
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| author | Maria Teresa Nascimento Silva Vlaudia Assis Costa Teobaldo Gonzaga Realço Pereira Iana Rafaela Fernandes Sales Silvana Ferreira da Silva Maria Amélia Vieira Maciel Elizabeth Malagueño Valdênia Maria Oliveira Souza |
| author_facet | Maria Teresa Nascimento Silva Vlaudia Assis Costa Teobaldo Gonzaga Realço Pereira Iana Rafaela Fernandes Sales Silvana Ferreira da Silva Maria Amélia Vieira Maciel Elizabeth Malagueño Valdênia Maria Oliveira Souza |
| author_sort | Maria Teresa Nascimento Silva |
| collection | DOAJ |
| description | INTRODUCTION: Ascaris lumbricoides-infected patients present lower prevalence of severe atopic dermatitis. METHODS: Peripheral blood of infected children with atopic dermatitis was assessed by flow cytometry of the frequency of Th1 and Th2 cells through the expression of CXCR3 and CCR4 chemokine receptors, respectively. RESULTS: Helminth-free patients with atopic dermatitis presented a high frequency of CCR4+Th2 cells. Parasitized patients with atopic dermatitis showed a lower frequency of CXCR3+Th1 cells compared to infected individuals only. CONCLUSIONS: Ascariasis modifies the blood traffic of Th2 cells in atopic dermatitis patients, while the allergic disease down-regulates the traffic of Th1 cells in parasitized patients. |
| first_indexed | 2024-04-12T18:02:26Z |
| format | Article |
| id | doaj.art-81283c12d0144a02b38404b4c8c8e406 |
| institution | Directory Open Access Journal |
| issn | 1678-9849 |
| language | English |
| last_indexed | 2024-04-12T18:02:26Z |
| publishDate | 2012-12-01 |
| publisher | Sociedade Brasileira de Medicina Tropical (SBMT) |
| record_format | Article |
| series | Revista da Sociedade Brasileira de Medicina Tropical |
| spelling | doaj.art-81283c12d0144a02b38404b4c8c8e4062022-12-22T03:22:05ZengSociedade Brasileira de Medicina Tropical (SBMT)Revista da Sociedade Brasileira de Medicina Tropical1678-98492012-12-0145676176310.1590/S0037-86822012000600021S0037-86822012000600021Severity of atopic dermatitis and Ascaris lumbricoides infection: an evaluation of CCR4+ and CXCR3+ helper T cell frequencyMaria Teresa Nascimento Silva0Vlaudia Assis Costa1Teobaldo Gonzaga Realço Pereira2Iana Rafaela Fernandes Sales3Silvana Ferreira da Silva4Maria Amélia Vieira Maciel5Elizabeth Malagueño6Valdênia Maria Oliveira Souza7Universidade Federal de Campina GrandeUniversidade Federal de PernambucoUniversidade Federal de Campina GrandeUniversidade Federal de PernambucoUniversidade Federal de PernambucoUniversidade Federal de PernambucoUniversidade Federal de PernambucoUniversidade Federal de PernambucoINTRODUCTION: Ascaris lumbricoides-infected patients present lower prevalence of severe atopic dermatitis. METHODS: Peripheral blood of infected children with atopic dermatitis was assessed by flow cytometry of the frequency of Th1 and Th2 cells through the expression of CXCR3 and CCR4 chemokine receptors, respectively. RESULTS: Helminth-free patients with atopic dermatitis presented a high frequency of CCR4+Th2 cells. Parasitized patients with atopic dermatitis showed a lower frequency of CXCR3+Th1 cells compared to infected individuals only. CONCLUSIONS: Ascariasis modifies the blood traffic of Th2 cells in atopic dermatitis patients, while the allergic disease down-regulates the traffic of Th1 cells in parasitized patients.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822012000600021&lng=en&tlng=enDermatite atópicaAscaris lumbricoidesReceptores CCR4 e CXCR3 |
| spellingShingle | Maria Teresa Nascimento Silva Vlaudia Assis Costa Teobaldo Gonzaga Realço Pereira Iana Rafaela Fernandes Sales Silvana Ferreira da Silva Maria Amélia Vieira Maciel Elizabeth Malagueño Valdênia Maria Oliveira Souza Severity of atopic dermatitis and Ascaris lumbricoides infection: an evaluation of CCR4+ and CXCR3+ helper T cell frequency Revista da Sociedade Brasileira de Medicina Tropical Dermatite atópica Ascaris lumbricoides Receptores CCR4 e CXCR3 |
| title | Severity of atopic dermatitis and Ascaris lumbricoides infection: an evaluation of CCR4+ and CXCR3+ helper T cell frequency |
| title_full | Severity of atopic dermatitis and Ascaris lumbricoides infection: an evaluation of CCR4+ and CXCR3+ helper T cell frequency |
| title_fullStr | Severity of atopic dermatitis and Ascaris lumbricoides infection: an evaluation of CCR4+ and CXCR3+ helper T cell frequency |
| title_full_unstemmed | Severity of atopic dermatitis and Ascaris lumbricoides infection: an evaluation of CCR4+ and CXCR3+ helper T cell frequency |
| title_short | Severity of atopic dermatitis and Ascaris lumbricoides infection: an evaluation of CCR4+ and CXCR3+ helper T cell frequency |
| title_sort | severity of atopic dermatitis and ascaris lumbricoides infection an evaluation of ccr4 and cxcr3 helper t cell frequency |
| topic | Dermatite atópica Ascaris lumbricoides Receptores CCR4 e CXCR3 |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822012000600021&lng=en&tlng=en |
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