The Structure-Activity Relationship between Marine Algae Polysaccharides and Anti-Complement Activity
In this study, 33 different polysaccharides were prepared to investigate the structure-activity relationships between the polysaccharides, mainly from marine algae, and anti-complement activity in the classical pathway. Factors considered included extraction methods, fractionations, molecular weight...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2015-12-01
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| Series: | Marine Drugs |
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| Online Access: | http://www.mdpi.com/1660-3397/14/1/3 |
| _version_ | 1818035049879044096 |
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| author | Weihua Jin Wenjing Zhang Hongze Liang Quanbin Zhang |
| author_facet | Weihua Jin Wenjing Zhang Hongze Liang Quanbin Zhang |
| author_sort | Weihua Jin |
| collection | DOAJ |
| description | In this study, 33 different polysaccharides were prepared to investigate the structure-activity relationships between the polysaccharides, mainly from marine algae, and anti-complement activity in the classical pathway. Factors considered included extraction methods, fractionations, molecular weight, molar ratio of galactose to fucose, sulfate, uronic acid (UA) content, linkage, branching, and the type of monosaccharide. It was shown that the larger the molecular weights, the better the activities. The molar ratio of galactose (Gal) to fucose (Fuc) was a positive factor at a concentration lower than 10 µg/mL, while it had no effect at a concentration more than 10 µg/mL. In addition, sulfate was necessary; however, the sulfate content, the sulfate pattern, linkage and branching had no effect at a concentration of more than 10 µg/mL. Moreover, the type of monosaccharide had no effect. Laminaran and UA fractions had no activity; however, they could reduce the activity by decreasing the effective concentration of the active composition when they were mixed with the active compositions. The effect of the extraction methods could not be determined. Finally, it was observed that sulfated galactofucan showed good anti-complement activity after separation. |
| first_indexed | 2024-12-10T06:48:53Z |
| format | Article |
| id | doaj.art-8128d2918eb54ee98c461cfb366f20b3 |
| institution | Directory Open Access Journal |
| issn | 1660-3397 |
| language | English |
| last_indexed | 2024-12-10T06:48:53Z |
| publishDate | 2015-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Marine Drugs |
| spelling | doaj.art-8128d2918eb54ee98c461cfb366f20b32022-12-22T01:58:35ZengMDPI AGMarine Drugs1660-33972015-12-01141310.3390/md14010003md14010003The Structure-Activity Relationship between Marine Algae Polysaccharides and Anti-Complement ActivityWeihua Jin0Wenjing Zhang1Hongze Liang2Quanbin Zhang3Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071, ChinaKey Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071, ChinaThe School of Materials Sciences and Chemical Engineering, Ningbo University, Ningbo 315211, ChinaKey Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071, ChinaIn this study, 33 different polysaccharides were prepared to investigate the structure-activity relationships between the polysaccharides, mainly from marine algae, and anti-complement activity in the classical pathway. Factors considered included extraction methods, fractionations, molecular weight, molar ratio of galactose to fucose, sulfate, uronic acid (UA) content, linkage, branching, and the type of monosaccharide. It was shown that the larger the molecular weights, the better the activities. The molar ratio of galactose (Gal) to fucose (Fuc) was a positive factor at a concentration lower than 10 µg/mL, while it had no effect at a concentration more than 10 µg/mL. In addition, sulfate was necessary; however, the sulfate content, the sulfate pattern, linkage and branching had no effect at a concentration of more than 10 µg/mL. Moreover, the type of monosaccharide had no effect. Laminaran and UA fractions had no activity; however, they could reduce the activity by decreasing the effective concentration of the active composition when they were mixed with the active compositions. The effect of the extraction methods could not be determined. Finally, it was observed that sulfated galactofucan showed good anti-complement activity after separation.http://www.mdpi.com/1660-3397/14/1/3marine algae polysaccharidesanti-complement activitystructure-activity relationship |
| spellingShingle | Weihua Jin Wenjing Zhang Hongze Liang Quanbin Zhang The Structure-Activity Relationship between Marine Algae Polysaccharides and Anti-Complement Activity Marine Drugs marine algae polysaccharides anti-complement activity structure-activity relationship |
| title | The Structure-Activity Relationship between Marine Algae Polysaccharides and Anti-Complement Activity |
| title_full | The Structure-Activity Relationship between Marine Algae Polysaccharides and Anti-Complement Activity |
| title_fullStr | The Structure-Activity Relationship between Marine Algae Polysaccharides and Anti-Complement Activity |
| title_full_unstemmed | The Structure-Activity Relationship between Marine Algae Polysaccharides and Anti-Complement Activity |
| title_short | The Structure-Activity Relationship between Marine Algae Polysaccharides and Anti-Complement Activity |
| title_sort | structure activity relationship between marine algae polysaccharides and anti complement activity |
| topic | marine algae polysaccharides anti-complement activity structure-activity relationship |
| url | http://www.mdpi.com/1660-3397/14/1/3 |
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