Poly-ion complex (PIC) formation of heparin and polyamines: PIC with tetrakis (3-aminopropyl) ammonium allows sustained release of heparin

Poly-ion complex (PIC) formation of heparin and polyamines: PIC with tetrakis (3-aminopropyl) ammonium allows sustained release of heparin

Physical mixtures of cationic polymers and heparin have been developed to overcome the limitations of unfractionated heparin. In this study, we found that heparin associates with natural polyamines in water, resulting in the generation of a poly-ion complex (PIC). PIC formation (or stability) was in...

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Bibliographic Details
Main Authors: Daichi Ito, Dan Ge, Noriyuki Kogure, Hitomi Manaka, Yusuke Terui, Hiromitsu Takayama, Robert J. Linhardt, Toshihiko Toida, Kyohei Higashi
Format: Article
Language:English
Published: Elsevier 2020-10-01
Series:Heliyon
Subjects:
Poly-ion complex
Polyamine
Sustained release of heparin
Materials application
Materials characterization
Biotechnology
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844020320119

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