Skeletal Deficits in Male and Female down Syndrome Model Mice Arise Independent of Normalized Dyrk1a Expression in Osteoblasts

Skeletal Deficits in Male and Female down Syndrome Model Mice Arise Independent of Normalized Dyrk1a Expression in Osteoblasts

Trisomy 21 (Ts21) causes alterations in skeletal development resulting in decreased bone mass, shortened stature and weaker bones in individuals with Down syndrome (DS). There is a sexual dimorphism in bone mineral density (BMD) deficits associated with DS with males displaying earlier deficits than...

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Bibliographic Details
Main Authors: Jared R. Thomas, Kourtney Sloan, Kelsey Cave, Joseph M. Wallace, Randall J. Roper
Format: Article
Language:English
Published: MDPI AG 2021-10-01
Series:Genes
Subjects:
DYRK1A
Down syndrome
osteoblasts
sexual dimorphism
gene dosage
skeletal abnormalities
Online Access:https://www.mdpi.com/2073-4425/12/11/1729

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