Transcriptomic and fluxomic changes in Streptomyces lividans producing heterologous protein

Transcriptomic and fluxomic changes in Streptomyces lividans producing heterologous protein

Abstract Background The Gram-positive Streptomyces lividans TK24 is an attractive host for heterologous protein production because of its high capability to secrete proteins—which favors correct folding and facilitates downstream processing—as well as its acceptance of methylated DNA and its low end...

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Bibliographic Details
Main Authors: Wouter Daniels, Jeroen Bouvin, Tobias Busche, Christian Rückert, Kenneth Simoens, Spyridoula Karamanou, Lieve Van Mellaert, Ólafur H. Friðjónsson, Bart Nicolai, Anastassios Economou, Jörn Kalinowski, Jozef Anné, Kristel Bernaerts
Format: Article
Language:English
Published: BMC 2018-12-01
Series:Microbial Cell Factories
Subjects:
Streptomyces lividans
Heterologous protein production and secretion
$$^{13}\hbox {C}$$ 13 C -based metabolic flux
RNA-seq analysis
Gene clustering analysis
Online Access:http://link.springer.com/article/10.1186/s12934-018-1040-6

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