Simplification of dosimetry in 90Y-radioembolization therapy by dual planar images
Abstract Aim The purpose was to provide a practical and effective method for performing reliable 90Y dosimetry based on 99mTc-MAA and SPEC/CT. The impact of scatter correction (SC) and attenuation correction (AC) on the injected 90Y activity, lung shunt fraction (LSF) and the delivered dose to lung...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2022-12-01
|
| Series: | BMC Cancer |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12885-022-10392-y |
| _version_ | 1811203720016297984 |
|---|---|
| author | Mohammad Abuqbeitah Özgür Taylan Akdağ Mustafa Demir Sertaç Asa Kerim Sönmezoğlu |
| author_facet | Mohammad Abuqbeitah Özgür Taylan Akdağ Mustafa Demir Sertaç Asa Kerim Sönmezoğlu |
| author_sort | Mohammad Abuqbeitah |
| collection | DOAJ |
| description | Abstract Aim The purpose was to provide a practical and effective method for performing reliable 90Y dosimetry based on 99mTc-MAA and SPEC/CT. The impact of scatter correction (SC) and attenuation correction (AC) on the injected 90Y activity, lung shunt fraction (LSF) and the delivered dose to lung and liver compartments was investigated within the scope of the study. Material and methods Eighteen eligible patients (F: 3, M: 15) were subjected to 90Y therapy. 99mTc-MAA (111-222 MBq) was injected into the targeted liver, followed by whole-body scan (WBS) with peak-window at 140 keV (15% width) and one down-scatter window. SPECT/CT scan was subsequently acquired encompassing lung and liver regions. The LSFs were fashioned from standard WBS LSFwb (St), scatter corrected WBS LSFwb (Sc), only scatter corrected SPECT LSFspect (NoAC-SC) and SPECT/CT with attenuation and scatter correction LSFspect (AC-SC). The absorbed doses that would be delivered to tumor and injected healthy liver were estimated using different calculation modes involving AC-SC (SPECT/CT), NoAC-SC (SPECT), NoAC-NoSC+LSFwb (SC), AC-SC + LSFwb (St), and NoAC-NoSC+LSFwb (St). Results The average deviations (range) in LSF values between standard LSFwb (St) and those from SPECT/CT (AC-SC), SPECT (NoAC-SC), and LSFwb (SC) were − 50% (− 29/− 71), − 32% (− 8/− 67), and − 45% (− 13/80), respectively. The suggested 90Y activity (GBq/Gy) was decreased within a range of 2-11%, 1-9%, and 2-7% by using LSFspect (AC-SC), LSFspect (NoAC-SC), and LSFwb (SC), respectively. Overall, two-sample t-test yielded no statistically significant difference (p < 0.05) in the absorbed doses to tumor and injected healthy liver between AC-SC (SPECT) and the rest of approaches with/and without AC and SC. However, a statistically significant difference (p < 0.05) was demonstrated in the lung shunt fractions and lung doses due to AC and SC. The LSFs from scatter corrected planar images LSFwb (SC) exhibited well agreement (R2 = 0.92) with SPECT/CT (AC-SC) and there was no statistically significant difference (P value > 0.05) between both methods. Conclusion It was deduced that SPECT/CT with attenuation and scatter correction plays a crucial role in the measurements of lung shunt fraction and dose as well as the total number of 90Y treatments. However, the absorbed dose to tumors and injected healthy liver was minimally affected by AC and SC. Besides, a good agreement was observed between LSF datasets from SPECT/CT versus scatter corrected WBS that can be alternatively and effectively used in 90Y dosimetry. |
| first_indexed | 2024-04-12T03:00:51Z |
| format | Article |
| id | doaj.art-812e2d269a1341f7a3b44a6e4568d7d2 |
| institution | Directory Open Access Journal |
| issn | 1471-2407 |
| language | English |
| last_indexed | 2024-04-12T03:00:51Z |
| publishDate | 2022-12-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Cancer |
| spelling | doaj.art-812e2d269a1341f7a3b44a6e4568d7d22022-12-22T03:50:41ZengBMCBMC Cancer1471-24072022-12-0122111010.1186/s12885-022-10392-ySimplification of dosimetry in 90Y-radioembolization therapy by dual planar imagesMohammad Abuqbeitah0Özgür Taylan Akdağ1Mustafa Demir2Sertaç Asa3Kerim Sönmezoğlu4Department of Nuclear Medicine, Istanbul University - Cerrahpasa, Cerrahpasa Faculty of MedicineDepartment of Nuclear Medicine, Istanbul University - Cerrahpasa, Cerrahpasa Faculty of MedicineDepartment of Nuclear Medicine, Istanbul University - Cerrahpasa, Cerrahpasa Faculty of MedicineDepartment of Nuclear Medicine, Istanbul University - Cerrahpasa, Cerrahpasa Faculty of MedicineDepartment of Nuclear Medicine, Istanbul University - Cerrahpasa, Cerrahpasa Faculty of MedicineAbstract Aim The purpose was to provide a practical and effective method for performing reliable 90Y dosimetry based on 99mTc-MAA and SPEC/CT. The impact of scatter correction (SC) and attenuation correction (AC) on the injected 90Y activity, lung shunt fraction (LSF) and the delivered dose to lung and liver compartments was investigated within the scope of the study. Material and methods Eighteen eligible patients (F: 3, M: 15) were subjected to 90Y therapy. 99mTc-MAA (111-222 MBq) was injected into the targeted liver, followed by whole-body scan (WBS) with peak-window at 140 keV (15% width) and one down-scatter window. SPECT/CT scan was subsequently acquired encompassing lung and liver regions. The LSFs were fashioned from standard WBS LSFwb (St), scatter corrected WBS LSFwb (Sc), only scatter corrected SPECT LSFspect (NoAC-SC) and SPECT/CT with attenuation and scatter correction LSFspect (AC-SC). The absorbed doses that would be delivered to tumor and injected healthy liver were estimated using different calculation modes involving AC-SC (SPECT/CT), NoAC-SC (SPECT), NoAC-NoSC+LSFwb (SC), AC-SC + LSFwb (St), and NoAC-NoSC+LSFwb (St). Results The average deviations (range) in LSF values between standard LSFwb (St) and those from SPECT/CT (AC-SC), SPECT (NoAC-SC), and LSFwb (SC) were − 50% (− 29/− 71), − 32% (− 8/− 67), and − 45% (− 13/80), respectively. The suggested 90Y activity (GBq/Gy) was decreased within a range of 2-11%, 1-9%, and 2-7% by using LSFspect (AC-SC), LSFspect (NoAC-SC), and LSFwb (SC), respectively. Overall, two-sample t-test yielded no statistically significant difference (p < 0.05) in the absorbed doses to tumor and injected healthy liver between AC-SC (SPECT) and the rest of approaches with/and without AC and SC. However, a statistically significant difference (p < 0.05) was demonstrated in the lung shunt fractions and lung doses due to AC and SC. The LSFs from scatter corrected planar images LSFwb (SC) exhibited well agreement (R2 = 0.92) with SPECT/CT (AC-SC) and there was no statistically significant difference (P value > 0.05) between both methods. Conclusion It was deduced that SPECT/CT with attenuation and scatter correction plays a crucial role in the measurements of lung shunt fraction and dose as well as the total number of 90Y treatments. However, the absorbed dose to tumors and injected healthy liver was minimally affected by AC and SC. Besides, a good agreement was observed between LSF datasets from SPECT/CT versus scatter corrected WBS that can be alternatively and effectively used in 90Y dosimetry.https://doi.org/10.1186/s12885-022-10392-y90Y therapyDosimetryLSFAttenuation & scatter correctionAbsorbed dose |
| spellingShingle | Mohammad Abuqbeitah Özgür Taylan Akdağ Mustafa Demir Sertaç Asa Kerim Sönmezoğlu Simplification of dosimetry in 90Y-radioembolization therapy by dual planar images BMC Cancer 90Y therapy Dosimetry LSF Attenuation & scatter correction Absorbed dose |
| title | Simplification of dosimetry in 90Y-radioembolization therapy by dual planar images |
| title_full | Simplification of dosimetry in 90Y-radioembolization therapy by dual planar images |
| title_fullStr | Simplification of dosimetry in 90Y-radioembolization therapy by dual planar images |
| title_full_unstemmed | Simplification of dosimetry in 90Y-radioembolization therapy by dual planar images |
| title_short | Simplification of dosimetry in 90Y-radioembolization therapy by dual planar images |
| title_sort | simplification of dosimetry in 90y radioembolization therapy by dual planar images |
| topic | 90Y therapy Dosimetry LSF Attenuation & scatter correction Absorbed dose |
| url | https://doi.org/10.1186/s12885-022-10392-y |
| work_keys_str_mv | AT mohammadabuqbeitah simplificationofdosimetryin90yradioembolizationtherapybydualplanarimages AT ozgurtaylanakdag simplificationofdosimetryin90yradioembolizationtherapybydualplanarimages AT mustafademir simplificationofdosimetryin90yradioembolizationtherapybydualplanarimages AT sertacasa simplificationofdosimetryin90yradioembolizationtherapybydualplanarimages AT kerimsonmezoglu simplificationofdosimetryin90yradioembolizationtherapybydualplanarimages |