Triacylglycerol fatty acid composition in diet-induced weight loss in subjects with abnormal glucose metabolism--the GENOBIN study.
The effect of weight loss on different plasma lipid subclasses at the molecular level is unknown. The aim of this study was to examine whether a diet-induced weight reduction result in changes in the extended plasma lipid profiles (lipidome) in subjects with features of metabolic syndrome in a 33-we...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2008-07-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC2440352?pdf=render |
| _version_ | 1818511217770102784 |
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| author | Ursula Schwab Tuulikki Seppänen-Laakso Laxman Yetukuri Jyrki Agren Marjukka Kolehmainen David E Laaksonen Anna-Liisa Ruskeepää Helena Gylling Matti Uusitupa Matej Oresic GENOBIN Study Group |
| author_facet | Ursula Schwab Tuulikki Seppänen-Laakso Laxman Yetukuri Jyrki Agren Marjukka Kolehmainen David E Laaksonen Anna-Liisa Ruskeepää Helena Gylling Matti Uusitupa Matej Oresic GENOBIN Study Group |
| author_sort | Ursula Schwab |
| collection | DOAJ |
| description | The effect of weight loss on different plasma lipid subclasses at the molecular level is unknown. The aim of this study was to examine whether a diet-induced weight reduction result in changes in the extended plasma lipid profiles (lipidome) in subjects with features of metabolic syndrome in a 33-week intervention.Plasma samples of 9 subjects in the weight reduction group and 10 subjects in the control group were analyzed using mass spectrometry based lipidomic and fatty acid analyses. Body weight decreased in the weight reduction group by 7.8+/-2.9% (p<0.01). Most of the serum triacylglycerols and phosphatidylcholines were reduced. The decrease in triacylglycerols affected predominantly the saturated short chain fatty acids. This decrease of saturated short chain fatty acid containing triacylglycerols correlated with the increase of insulin sensitivity. However, levels of several longer chain fatty acids, including arachidonic and docosahexanoic acid, were not affected by weight loss. Levels of other lipids known to be associated with obesity such as sphingolipids and lysophosphatidylcholines were not altered by weight reduction.Diet-induced weight loss caused significant changes in global lipid profiles in subjects with abnormal glucose metabolism. The observed changes may affect insulin sensitivity and glucose metabolism in these subjects.ClinicalTrials.gov NCT00621205. |
| first_indexed | 2024-12-10T23:30:24Z |
| format | Article |
| id | doaj.art-8134e58d951a4533bf5d183eda29703e |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-10T23:30:24Z |
| publishDate | 2008-07-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-8134e58d951a4533bf5d183eda29703e2022-12-22T01:29:25ZengPublic Library of Science (PLoS)PLoS ONE1932-62032008-07-0137e263010.1371/journal.pone.0002630Triacylglycerol fatty acid composition in diet-induced weight loss in subjects with abnormal glucose metabolism--the GENOBIN study.Ursula SchwabTuulikki Seppänen-LaaksoLaxman YetukuriJyrki AgrenMarjukka KolehmainenDavid E LaaksonenAnna-Liisa RuskeepääHelena GyllingMatti UusitupaMatej OresicGENOBIN Study GroupThe effect of weight loss on different plasma lipid subclasses at the molecular level is unknown. The aim of this study was to examine whether a diet-induced weight reduction result in changes in the extended plasma lipid profiles (lipidome) in subjects with features of metabolic syndrome in a 33-week intervention.Plasma samples of 9 subjects in the weight reduction group and 10 subjects in the control group were analyzed using mass spectrometry based lipidomic and fatty acid analyses. Body weight decreased in the weight reduction group by 7.8+/-2.9% (p<0.01). Most of the serum triacylglycerols and phosphatidylcholines were reduced. The decrease in triacylglycerols affected predominantly the saturated short chain fatty acids. This decrease of saturated short chain fatty acid containing triacylglycerols correlated with the increase of insulin sensitivity. However, levels of several longer chain fatty acids, including arachidonic and docosahexanoic acid, were not affected by weight loss. Levels of other lipids known to be associated with obesity such as sphingolipids and lysophosphatidylcholines were not altered by weight reduction.Diet-induced weight loss caused significant changes in global lipid profiles in subjects with abnormal glucose metabolism. The observed changes may affect insulin sensitivity and glucose metabolism in these subjects.ClinicalTrials.gov NCT00621205.http://europepmc.org/articles/PMC2440352?pdf=render |
| spellingShingle | Ursula Schwab Tuulikki Seppänen-Laakso Laxman Yetukuri Jyrki Agren Marjukka Kolehmainen David E Laaksonen Anna-Liisa Ruskeepää Helena Gylling Matti Uusitupa Matej Oresic GENOBIN Study Group Triacylglycerol fatty acid composition in diet-induced weight loss in subjects with abnormal glucose metabolism--the GENOBIN study. PLoS ONE |
| title | Triacylglycerol fatty acid composition in diet-induced weight loss in subjects with abnormal glucose metabolism--the GENOBIN study. |
| title_full | Triacylglycerol fatty acid composition in diet-induced weight loss in subjects with abnormal glucose metabolism--the GENOBIN study. |
| title_fullStr | Triacylglycerol fatty acid composition in diet-induced weight loss in subjects with abnormal glucose metabolism--the GENOBIN study. |
| title_full_unstemmed | Triacylglycerol fatty acid composition in diet-induced weight loss in subjects with abnormal glucose metabolism--the GENOBIN study. |
| title_short | Triacylglycerol fatty acid composition in diet-induced weight loss in subjects with abnormal glucose metabolism--the GENOBIN study. |
| title_sort | triacylglycerol fatty acid composition in diet induced weight loss in subjects with abnormal glucose metabolism the genobin study |
| url | http://europepmc.org/articles/PMC2440352?pdf=render |
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