KYNA Derivatives with Modified Skeleton; Hydroxyquinolines with Potential Neuroprotective Effect
Kynurenic acid (KYNA) is an endogenous neuroprotective agent of increasing importance. Several derivatives have already been synthesized, bearing an abundance of functional groups attached to the main skeleton in different positions. Several of these compounds have already been tested in biological...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-11-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/22/21/11935 |
| _version_ | 1797512366814920704 |
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| author | Bálint Lőrinczi István Szatmári |
| author_facet | Bálint Lőrinczi István Szatmári |
| author_sort | Bálint Lőrinczi |
| collection | DOAJ |
| description | Kynurenic acid (KYNA) is an endogenous neuroprotective agent of increasing importance. Several derivatives have already been synthesized, bearing an abundance of functional groups attached to the main skeleton in different positions. Several of these compounds have already been tested in biological evaluations, with several of them targeting the same receptors and biological effects as KYNA. However, these modified compounds build upon the unmodified KYNA skeleton leaving a possible route for the synthesis of new, potentially neuroprotective derivatives with heteroatom-containing ring systems. The aim of this review is to summarize the syntheses of KYNA derivatives with altered skeletons and to pinpoint an appealing transformation for future medicinal lead molecules. |
| first_indexed | 2024-03-10T06:00:47Z |
| format | Article |
| id | doaj.art-813664015e134dd785086567adaecee0 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T06:00:47Z |
| publishDate | 2021-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-813664015e134dd785086567adaecee02023-11-22T21:00:10ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-11-0122211193510.3390/ijms222111935KYNA Derivatives with Modified Skeleton; Hydroxyquinolines with Potential Neuroprotective EffectBálint Lőrinczi0István Szatmári1Institute of Pharmaceutical Chemistry, University of Szeged, Eötvös u. 6, H-6720 Szeged, HungaryInstitute of Pharmaceutical Chemistry, University of Szeged, Eötvös u. 6, H-6720 Szeged, HungaryKynurenic acid (KYNA) is an endogenous neuroprotective agent of increasing importance. Several derivatives have already been synthesized, bearing an abundance of functional groups attached to the main skeleton in different positions. Several of these compounds have already been tested in biological evaluations, with several of them targeting the same receptors and biological effects as KYNA. However, these modified compounds build upon the unmodified KYNA skeleton leaving a possible route for the synthesis of new, potentially neuroprotective derivatives with heteroatom-containing ring systems. The aim of this review is to summarize the syntheses of KYNA derivatives with altered skeletons and to pinpoint an appealing transformation for future medicinal lead molecules.https://www.mdpi.com/1422-0067/22/21/11935kynurenic acidmodified hydroxyquinolinesConrad–Limpach reactionneuroprotectionmodified Mannich reaction |
| spellingShingle | Bálint Lőrinczi István Szatmári KYNA Derivatives with Modified Skeleton; Hydroxyquinolines with Potential Neuroprotective Effect International Journal of Molecular Sciences kynurenic acid modified hydroxyquinolines Conrad–Limpach reaction neuroprotection modified Mannich reaction |
| title | KYNA Derivatives with Modified Skeleton; Hydroxyquinolines with Potential Neuroprotective Effect |
| title_full | KYNA Derivatives with Modified Skeleton; Hydroxyquinolines with Potential Neuroprotective Effect |
| title_fullStr | KYNA Derivatives with Modified Skeleton; Hydroxyquinolines with Potential Neuroprotective Effect |
| title_full_unstemmed | KYNA Derivatives with Modified Skeleton; Hydroxyquinolines with Potential Neuroprotective Effect |
| title_short | KYNA Derivatives with Modified Skeleton; Hydroxyquinolines with Potential Neuroprotective Effect |
| title_sort | kyna derivatives with modified skeleton hydroxyquinolines with potential neuroprotective effect |
| topic | kynurenic acid modified hydroxyquinolines Conrad–Limpach reaction neuroprotection modified Mannich reaction |
| url | https://www.mdpi.com/1422-0067/22/21/11935 |
| work_keys_str_mv | AT balintlorinczi kynaderivativeswithmodifiedskeletonhydroxyquinolineswithpotentialneuroprotectiveeffect AT istvanszatmari kynaderivativeswithmodifiedskeletonhydroxyquinolineswithpotentialneuroprotectiveeffect |