UNC93B1 mediates differential trafficking of endosomal TLRs

UNC93B1 mediates differential trafficking of endosomal TLRs

UNC93B1, a multipass transmembrane protein required for TLR3, TLR7, TLR9, TLR11, TLR12, and TLR13 function, controls trafficking of TLRs from the endoplasmic reticulum (ER) to endolysosomes. The mechanisms by which UNC93B1 mediates these regulatory effects remain unclear. Here, we demonstrate that U...

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Bibliographic Details
Main Authors: Bettina L Lee, Joanne E Moon, Jeffrey H Shu, Lin Yuan, Zachary R Newman, Randy Schekman, Gregory M Barton
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2013-02-01
Series:eLife
Subjects:
Toll-like receptor
UNC93B1
trafficking
AP-2
Online Access:https://elifesciences.org/articles/00291

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