The SKP2‐p27 axis defines susceptibility to cell death upon CHK1 inhibition

The SKP2‐p27 axis defines susceptibility to cell death upon CHK1 inhibition

Checkpoint kinase 1 (CHK1; encoded by CHEK1) is an essential gene that monitors DNA replication fidelity and prevents mitotic entry in the presence of under‐replicated DNA or exogenous DNA damage. Cancer cells deficient in p53 tumor suppressor function reportedly develop a strong dependency on CHK1...

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Bibliographic Details
Main Authors: Michael Lohmüller, Bernhard F. Roeck, Tamas G. Szabo, Marina A. Schapfl, Fragka Pegka, Sebastian Herzog, Andreas Villunger, Fabian Schuler
Format: Article
Language:English
Published: Wiley 2022-08-01
Series:Molecular Oncology
Subjects:
apoptosis
cell cycle
CHK1 inhibition
DNA‐damage
p27
SKP2
Online Access:https://doi.org/10.1002/1878-0261.13264

Internet

https://doi.org/10.1002/1878-0261.13264

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