The Fine-Tuned Release of Antioxidant from Superparamagnetic Nanocarriers under the Combination of Stationary and Alternating Magnetic Fields
Superparamagnetic magnetite nanoparticles (MNPs) with excellent biocompatibility and negligible toxicity were prepared by solvothermal method and stabilized by widely used and biocompatible polymer poly(ethylene glycol) PEG-4000 Da. The unique properties of the synthesized MNPs enable them to host t...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-07-01
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| Series: | Antioxidants |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2076-3921/10/8/1212 |
| _version_ | 1797524849027973120 |
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| author | Lucija Mandić Anja Sadžak Ina Erceg Goran Baranović Suzana Šegota |
| author_facet | Lucija Mandić Anja Sadžak Ina Erceg Goran Baranović Suzana Šegota |
| author_sort | Lucija Mandić |
| collection | DOAJ |
| description | Superparamagnetic magnetite nanoparticles (MNPs) with excellent biocompatibility and negligible toxicity were prepared by solvothermal method and stabilized by widely used and biocompatible polymer poly(ethylene glycol) PEG-4000 Da. The unique properties of the synthesized MNPs enable them to host the unstable and water-insoluble quercetin as well as deliver and localize quercetin directly to the desired site. The chemical and physical properties were validated by X-ray powder diffraction (XRPD), field emission scanning electron microscopy (FE–SEM), atomic force microscopy (AFM), superconducting quantum interference device (SQUID) magnetometer, FTIR spectroscopy and dynamic light scattering (DLS). The kinetics of in vitro quercetin release from MNPs followed by UV/VIS spectroscopy was controlled by employing combined stationary and alternating magnetic fields. The obtained results have shown an increased response of quercetin from superparamagnetic MNPs under a lower stationary magnetic field and s higher frequency of alternating magnetic field. The achieved findings suggested that we designed promising targeted quercetin delivery with fine-tuning drug release from magnetic MNPs. |
| first_indexed | 2024-03-10T09:03:24Z |
| format | Article |
| id | doaj.art-813b7cab401645949c7464e9b7bb746b |
| institution | Directory Open Access Journal |
| issn | 2076-3921 |
| language | English |
| last_indexed | 2024-03-10T09:03:24Z |
| publishDate | 2021-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj.art-813b7cab401645949c7464e9b7bb746b2023-11-22T06:35:45ZengMDPI AGAntioxidants2076-39212021-07-01108121210.3390/antiox10081212The Fine-Tuned Release of Antioxidant from Superparamagnetic Nanocarriers under the Combination of Stationary and Alternating Magnetic FieldsLucija Mandić0Anja Sadžak1Ina Erceg2Goran Baranović3Suzana Šegota4Ruđer Bošković Institute, 10000 Zagreb, CroatiaRuđer Bošković Institute, 10000 Zagreb, CroatiaRuđer Bošković Institute, 10000 Zagreb, CroatiaRuđer Bošković Institute, 10000 Zagreb, CroatiaRuđer Bošković Institute, 10000 Zagreb, CroatiaSuperparamagnetic magnetite nanoparticles (MNPs) with excellent biocompatibility and negligible toxicity were prepared by solvothermal method and stabilized by widely used and biocompatible polymer poly(ethylene glycol) PEG-4000 Da. The unique properties of the synthesized MNPs enable them to host the unstable and water-insoluble quercetin as well as deliver and localize quercetin directly to the desired site. The chemical and physical properties were validated by X-ray powder diffraction (XRPD), field emission scanning electron microscopy (FE–SEM), atomic force microscopy (AFM), superconducting quantum interference device (SQUID) magnetometer, FTIR spectroscopy and dynamic light scattering (DLS). The kinetics of in vitro quercetin release from MNPs followed by UV/VIS spectroscopy was controlled by employing combined stationary and alternating magnetic fields. The obtained results have shown an increased response of quercetin from superparamagnetic MNPs under a lower stationary magnetic field and s higher frequency of alternating magnetic field. The achieved findings suggested that we designed promising targeted quercetin delivery with fine-tuning drug release from magnetic MNPs.https://www.mdpi.com/2076-3921/10/8/1212release kineticssuperparamagnetismstationary magnetic fieldalternating magnetic fieldsmagnetic nanoparticlesquercetin |
| spellingShingle | Lucija Mandić Anja Sadžak Ina Erceg Goran Baranović Suzana Šegota The Fine-Tuned Release of Antioxidant from Superparamagnetic Nanocarriers under the Combination of Stationary and Alternating Magnetic Fields Antioxidants release kinetics superparamagnetism stationary magnetic field alternating magnetic fields magnetic nanoparticles quercetin |
| title | The Fine-Tuned Release of Antioxidant from Superparamagnetic Nanocarriers under the Combination of Stationary and Alternating Magnetic Fields |
| title_full | The Fine-Tuned Release of Antioxidant from Superparamagnetic Nanocarriers under the Combination of Stationary and Alternating Magnetic Fields |
| title_fullStr | The Fine-Tuned Release of Antioxidant from Superparamagnetic Nanocarriers under the Combination of Stationary and Alternating Magnetic Fields |
| title_full_unstemmed | The Fine-Tuned Release of Antioxidant from Superparamagnetic Nanocarriers under the Combination of Stationary and Alternating Magnetic Fields |
| title_short | The Fine-Tuned Release of Antioxidant from Superparamagnetic Nanocarriers under the Combination of Stationary and Alternating Magnetic Fields |
| title_sort | fine tuned release of antioxidant from superparamagnetic nanocarriers under the combination of stationary and alternating magnetic fields |
| topic | release kinetics superparamagnetism stationary magnetic field alternating magnetic fields magnetic nanoparticles quercetin |
| url | https://www.mdpi.com/2076-3921/10/8/1212 |
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