FAK activity in cancer‐associated fibroblasts is a prognostic marker and a druggable key metastatic player in pancreatic cancer

FAK activity in cancer‐associated fibroblasts is a prognostic marker and a druggable key metastatic player in pancreatic cancer

Abstract Cancer‐associated fibroblasts (CAFs) are considered the most abundant type of stromal cells in pancreatic ductal adenocarcinoma (PDAC), playing a critical role in tumour progression and chemoresistance; however, a druggable target on CAFs has not yet been identified. Here we report that foc...

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Bibliographic Details
Main Authors: Sonia Zaghdoudi, Emilie Decaup, Ismahane Belhabib, Rémi Samain, Stéphanie Cassant‐Sourdy, Julia Rochotte, Alexia Brunel, David Schlaepfer, Jérome Cros, Cindy Neuzillet, Manon Strehaiano, Amandine Alard, Richard Tomasini, Vinothini Rajeeve, Aurélie Perraud, Muriel Mathonnet, Oliver MT Pearce, Yvan Martineau, Stéphane Pyronnet, Corinne Bousquet, Christine Jean
Format: Article
Language:English
Published: Springer Nature 2020-11-01
Series:EMBO Molecular Medicine
Subjects:
cancer‐associated fibroblasts
extracellular matrix remodelling
focal adhesion kinase
metastasis
pancreatic ductal adenocarcinoma
Online Access:https://doi.org/10.15252/emmm.202012010

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