New perspectives in signaling mediated by receptors coupled to stimulatory G protein: the emerging significance of cAMP efflux and extracellular cAMP-adenosine pathway.

New perspectives in signaling mediated by receptors coupled to stimulatory G protein: the emerging significance of cAMP efflux and extracellular cAMP-adenosine pathway.

G protein-coupled receptors (GPCR) linked to stimulatory G (Gs) proteins (GsPCR) mediate increases in intracellular cyclic AMP as consequence of activation of nine adenylyl cyclases (AC), which differ considerably in their cellular distribution and activation mechanisms. Once produced, cyclic AMP ma...

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Bibliographic Details
Main Authors: Rosely Oliveira Godinho, Thiago eDuarte, Enio Setsuo Arakaki Pacini
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-03-01
Series:Frontiers in Pharmacology
Subjects:
Adenosine
Cyclic AMP
ABC transporters
adenosine receptors
G protein-coupled receptors
cAMP efflux
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphar.2015.00058/full

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