Pituitary-testicular axis dysfunction in methimazole-induced hypothyroidism in rats
Introduction: Thyroid hormones play a major role in the regulation of testicular maturation and growth and in the control of Sertoli and Leydig cell functions in adulthood. When naturally occurring, hypothyroidism causes male hypogonadotropic hypogonadism and Sertoli cell function disorders, but whe...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Sciendo
2019-03-01
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| Series: | Journal of Veterinary Research |
| Subjects: | |
| Online Access: | https://doi.org/10.2478/jvetres-2019-0008 |
| _version_ | 1819242095851864064 |
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| author | Gołyński Marcin Metyk Michał Szkodziak Piotr Lutnicki Krzysztof Kalisz Grzegorz Szczepanik Marcin Wilkołek Piotr Dobrowolski Piotr |
| author_facet | Gołyński Marcin Metyk Michał Szkodziak Piotr Lutnicki Krzysztof Kalisz Grzegorz Szczepanik Marcin Wilkołek Piotr Dobrowolski Piotr |
| author_sort | Gołyński Marcin |
| collection | DOAJ |
| description | Introduction: Thyroid hormones play a major role in the regulation of testicular maturation and growth and in the control of Sertoli and Leydig cell functions in adulthood. When naturally occurring, hypothyroidism causes male hypogonadotropic hypogonadism and Sertoli cell function disorders, but when iatrogenic and methimazole-induced its influence on the pituitary-testicular axis function with respect to Sertoli cells is poorly known. |
| first_indexed | 2024-12-23T14:34:22Z |
| format | Article |
| id | doaj.art-813d7bb1afcd440baedad929d85a13c3 |
| institution | Directory Open Access Journal |
| issn | 2450-8608 |
| language | English |
| last_indexed | 2024-12-23T14:34:22Z |
| publishDate | 2019-03-01 |
| publisher | Sciendo |
| record_format | Article |
| series | Journal of Veterinary Research |
| spelling | doaj.art-813d7bb1afcd440baedad929d85a13c32022-12-21T17:43:25ZengSciendoJournal of Veterinary Research2450-86082019-03-0163116116610.2478/jvetres-2019-0008jvetres-2019-0008Pituitary-testicular axis dysfunction in methimazole-induced hypothyroidism in ratsGołyński Marcin0Metyk Michał1Szkodziak Piotr2Lutnicki Krzysztof3Kalisz Grzegorz4Szczepanik Marcin5Wilkołek Piotr6Dobrowolski Piotr7Department and Clinic of Animal Internal Diseases, Faculty of Veterinary Medicine, University of Life Sciences, 20-612Lublin, PolandDepartment and Clinic of Animal Internal Diseases, Faculty of Veterinary Medicine, University of Life Sciences, 20-612Lublin, Poland3rd Chair and Department of Gynecology, Medical University of Lublin, 20-954Lublin, PolandDepartment and Clinic of Animal Internal Diseases, Faculty of Veterinary Medicine, University of Life Sciences, 20-612Lublin, PolandDepartment of Biopharmacy, Chair of Chemistry, Faculty of Pharmacy with Medical Analytics Division, Medical University of Lublin, 20-093Lublin, PolandDepartment and Clinic of Animal Internal Diseases, Faculty of Veterinary Medicine, University of Life Sciences, 20-612Lublin, PolandDepartment and Clinic of Animal Internal Diseases, Faculty of Veterinary Medicine, University of Life Sciences, 20-612Lublin, PolandDepartment of Comparative Anatomy and Anthropology, Maria Curie-Skłodowska University, 20-033Lublin, PolandIntroduction: Thyroid hormones play a major role in the regulation of testicular maturation and growth and in the control of Sertoli and Leydig cell functions in adulthood. When naturally occurring, hypothyroidism causes male hypogonadotropic hypogonadism and Sertoli cell function disorders, but when iatrogenic and methimazole-induced its influence on the pituitary-testicular axis function with respect to Sertoli cells is poorly known.https://doi.org/10.2478/jvetres-2019-0008ratshypogonadisminhibinssex hormonesthionaminesthyroid gland |
| spellingShingle | Gołyński Marcin Metyk Michał Szkodziak Piotr Lutnicki Krzysztof Kalisz Grzegorz Szczepanik Marcin Wilkołek Piotr Dobrowolski Piotr Pituitary-testicular axis dysfunction in methimazole-induced hypothyroidism in rats Journal of Veterinary Research rats hypogonadism inhibins sex hormones thionamines thyroid gland |
| title | Pituitary-testicular axis dysfunction in methimazole-induced hypothyroidism in rats |
| title_full | Pituitary-testicular axis dysfunction in methimazole-induced hypothyroidism in rats |
| title_fullStr | Pituitary-testicular axis dysfunction in methimazole-induced hypothyroidism in rats |
| title_full_unstemmed | Pituitary-testicular axis dysfunction in methimazole-induced hypothyroidism in rats |
| title_short | Pituitary-testicular axis dysfunction in methimazole-induced hypothyroidism in rats |
| title_sort | pituitary testicular axis dysfunction in methimazole induced hypothyroidism in rats |
| topic | rats hypogonadism inhibins sex hormones thionamines thyroid gland |
| url | https://doi.org/10.2478/jvetres-2019-0008 |
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