Spectroscopic analysis of wild medicinal desert plants from wadi sanor (beni-suef), Egypt, and their antimicrobial and antioxidant activities
Desert plants possess untapped potential for medicinal applications due to their rich phytochemical profiles. However, they need to be more explored. Thus, this study integrates advanced analytical, biochemical, and molecular techniques to investigate the phytochemical composition and biological act...
| Hoofdauteurs: | , , , , , , , |
|---|---|
| Formaat: | Artikel |
| Taal: | English |
| Gepubliceerd in: |
Elsevier
2024-11-01
|
| Reeks: | Heliyon |
| Onderwerpen: | |
| Online toegang: | http://www.sciencedirect.com/science/article/pii/S2405844024156435 |
| _version_ | 1826979229697310720 |
|---|---|
| author | Amany H. El-Zairy Hussein S. Mohamed Shimaa A. Ahmed Sayed A. Ahmed Mohammad K. Okla Khaled El-Adl Hamada AbdElgawad Wael N. Hozzein |
| author_facet | Amany H. El-Zairy Hussein S. Mohamed Shimaa A. Ahmed Sayed A. Ahmed Mohammad K. Okla Khaled El-Adl Hamada AbdElgawad Wael N. Hozzein |
| author_sort | Amany H. El-Zairy |
| collection | DOAJ |
| description | Desert plants possess untapped potential for medicinal applications due to their rich phytochemical profiles. However, they need to be more explored. Thus, this study integrates advanced analytical, biochemical, and molecular techniques to investigate the phytochemical composition and biological activities (antimicrobial and antioxidant) of four desert plants (Pergularia tomentosa, Zygophyllum coccineum, Pulicaria undulata, and Ochradenus baccatus), collected from Wadi Sannor, Beni-Suef Governorate, Egypt, in March 2021. The volatile chemicals in the 70 % ethanol extracts of the selected plants were also analyzed using GC-MS. The extract exhibited strong antioxidant properties, as demonstrated by its FRAP (Ferric reducing ability of plasma) values, anti-lipid peroxidation, superoxide anion scavenging activity, and DPPH scavenging activity. Additionally, plants extracts showed high antimicrobial activities against seven pathogens, including three Gram-negative bacteria (Pseudomonas aeruginosa, Salmonella typhimurium, Escherichia coli) and four Gram-positive bacteria (Staphylococcus saprophyticus, Staphylococcus epidermidis, Enterococcus faecalis, Streptococcus salivarius). Lastly, molecular docking was conducted for cis-vaccenic acid, (E)-9-octadecenoic acid, the cyclohepta[b]furan-2-one scaffold, and URS-20(30)-en-3-ol against both the thymidylate kinase enzyme and the active sites of E. coli DNA gyrase. The results from the molecular docking studies showed a strong correlation with the biological data. Moreover, these compounds exhibited good, proposed absorption, distribution, metabolism, and excretion–toxicity (ADMET) profiles. Our study highlights the potential of P. tomentosa, Z. coccineum, P. undulata, and O. baccatus for future medical applications and the development of new pharmaceuticals derived from desert flora. |
| first_indexed | 2025-02-18T05:26:05Z |
| format | Article |
| id | doaj.art-813e6428af144c119c33f08c27913cb1 |
| institution | Directory Open Access Journal |
| issn | 2405-8440 |
| language | English |
| last_indexed | 2025-02-18T05:26:05Z |
| publishDate | 2024-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj.art-813e6428af144c119c33f08c27913cb12024-11-15T06:13:00ZengElsevierHeliyon2405-84402024-11-011021e39612Spectroscopic analysis of wild medicinal desert plants from wadi sanor (beni-suef), Egypt, and their antimicrobial and antioxidant activitiesAmany H. El-Zairy0Hussein S. Mohamed1Shimaa A. Ahmed2Sayed A. Ahmed3Mohammad K. Okla4Khaled El-Adl5Hamada AbdElgawad6Wael N. Hozzein7Chemistry of medicinal and aromatic plants department, Research Institute of Medicinal and Aromatic plants (RIMAP), Beni-Suef University, Beni-Suef, 62511, EgyptChemistry of medicinal and aromatic plants department, Research Institute of Medicinal and Aromatic plants (RIMAP), Beni-Suef University, Beni-Suef, 62511, Egypt; Corresponding author.Chemistry department, Faculty of Science, Beni-Suef University, Beni-Suef, 62511, EgyptChemistry department, Faculty of Science, Beni-Suef University, Beni-Suef, 62511, Egypt; Faculty of Engineering, Nahda University, Beni-Suef, EgyptBotany and Microbiology Department, College of Science, King Saud University, P.O. Box 2455, Riyadh, 11451, Saudi ArabiaChemistry Department, Faculty of Pharmacy, Heliopolis University for Sustainable Development, Cairo, Egypt; Pharmaceutical Medicinal Chemistry and Drug Design Department, Faculty of Pharmacy (Boys), Al-Azhar University, Nasr City, 11884, Cairo, EgyptIntegrated Molecular Plant Physiology Research (IMPRES), Department of Biology, University of Antwerp, BelgiumBotany and Microbiology Department, Faculty of Science, Beni-Suef University, Beni-Suef, EgyptDesert plants possess untapped potential for medicinal applications due to their rich phytochemical profiles. However, they need to be more explored. Thus, this study integrates advanced analytical, biochemical, and molecular techniques to investigate the phytochemical composition and biological activities (antimicrobial and antioxidant) of four desert plants (Pergularia tomentosa, Zygophyllum coccineum, Pulicaria undulata, and Ochradenus baccatus), collected from Wadi Sannor, Beni-Suef Governorate, Egypt, in March 2021. The volatile chemicals in the 70 % ethanol extracts of the selected plants were also analyzed using GC-MS. The extract exhibited strong antioxidant properties, as demonstrated by its FRAP (Ferric reducing ability of plasma) values, anti-lipid peroxidation, superoxide anion scavenging activity, and DPPH scavenging activity. Additionally, plants extracts showed high antimicrobial activities against seven pathogens, including three Gram-negative bacteria (Pseudomonas aeruginosa, Salmonella typhimurium, Escherichia coli) and four Gram-positive bacteria (Staphylococcus saprophyticus, Staphylococcus epidermidis, Enterococcus faecalis, Streptococcus salivarius). Lastly, molecular docking was conducted for cis-vaccenic acid, (E)-9-octadecenoic acid, the cyclohepta[b]furan-2-one scaffold, and URS-20(30)-en-3-ol against both the thymidylate kinase enzyme and the active sites of E. coli DNA gyrase. The results from the molecular docking studies showed a strong correlation with the biological data. Moreover, these compounds exhibited good, proposed absorption, distribution, metabolism, and excretion–toxicity (ADMET) profiles. Our study highlights the potential of P. tomentosa, Z. coccineum, P. undulata, and O. baccatus for future medical applications and the development of new pharmaceuticals derived from desert flora.http://www.sciencedirect.com/science/article/pii/S2405844024156435Biological activityChemical compositionGC-MSOchradenus baccatusPergularia tomentosaPulicaria undulata |
| spellingShingle | Amany H. El-Zairy Hussein S. Mohamed Shimaa A. Ahmed Sayed A. Ahmed Mohammad K. Okla Khaled El-Adl Hamada AbdElgawad Wael N. Hozzein Spectroscopic analysis of wild medicinal desert plants from wadi sanor (beni-suef), Egypt, and their antimicrobial and antioxidant activities Heliyon Biological activity Chemical composition GC-MS Ochradenus baccatus Pergularia tomentosa Pulicaria undulata |
| title | Spectroscopic analysis of wild medicinal desert plants from wadi sanor (beni-suef), Egypt, and their antimicrobial and antioxidant activities |
| title_full | Spectroscopic analysis of wild medicinal desert plants from wadi sanor (beni-suef), Egypt, and their antimicrobial and antioxidant activities |
| title_fullStr | Spectroscopic analysis of wild medicinal desert plants from wadi sanor (beni-suef), Egypt, and their antimicrobial and antioxidant activities |
| title_full_unstemmed | Spectroscopic analysis of wild medicinal desert plants from wadi sanor (beni-suef), Egypt, and their antimicrobial and antioxidant activities |
| title_short | Spectroscopic analysis of wild medicinal desert plants from wadi sanor (beni-suef), Egypt, and their antimicrobial and antioxidant activities |
| title_sort | spectroscopic analysis of wild medicinal desert plants from wadi sanor beni suef egypt and their antimicrobial and antioxidant activities |
| topic | Biological activity Chemical composition GC-MS Ochradenus baccatus Pergularia tomentosa Pulicaria undulata |
| url | http://www.sciencedirect.com/science/article/pii/S2405844024156435 |
| work_keys_str_mv | AT amanyhelzairy spectroscopicanalysisofwildmedicinaldesertplantsfromwadisanorbenisuefegyptandtheirantimicrobialandantioxidantactivities AT husseinsmohamed spectroscopicanalysisofwildmedicinaldesertplantsfromwadisanorbenisuefegyptandtheirantimicrobialandantioxidantactivities AT shimaaaahmed spectroscopicanalysisofwildmedicinaldesertplantsfromwadisanorbenisuefegyptandtheirantimicrobialandantioxidantactivities AT sayedaahmed spectroscopicanalysisofwildmedicinaldesertplantsfromwadisanorbenisuefegyptandtheirantimicrobialandantioxidantactivities AT mohammadkokla spectroscopicanalysisofwildmedicinaldesertplantsfromwadisanorbenisuefegyptandtheirantimicrobialandantioxidantactivities AT khaledeladl spectroscopicanalysisofwildmedicinaldesertplantsfromwadisanorbenisuefegyptandtheirantimicrobialandantioxidantactivities AT hamadaabdelgawad spectroscopicanalysisofwildmedicinaldesertplantsfromwadisanorbenisuefegyptandtheirantimicrobialandantioxidantactivities AT waelnhozzein spectroscopicanalysisofwildmedicinaldesertplantsfromwadisanorbenisuefegyptandtheirantimicrobialandantioxidantactivities |