Primary biliary cirrhosis and hepatic sarcoidosis: A case report
Introduction. Primary biliary cirrhosis (PBC) is an immunemediated chronic progressive inflammatory liver disease leading to destruction of small interlobular bile ducts. Sarcoidosis is a chronic disorder of unknown etiology characterized by non-caseous granulomas. Case report. We reported...
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| Format: | Article |
| Language: | English |
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Military Health Department, Ministry of Defance, Serbia
2014-01-01
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| Series: | Vojnosanitetski Pregled |
| Subjects: | |
| Online Access: | http://www.doiserbia.nb.rs/img/doi/0042-8450/2014/0042-84501401083A.pdf |
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| author | Alempijević Tamara Sokić-Milutinović Aleksandra Tončev Ljubiša Pavlović-Marković Aleksandra Đuranović Srđan Tomanović Nada Drulović Jelena |
| author_facet | Alempijević Tamara Sokić-Milutinović Aleksandra Tončev Ljubiša Pavlović-Marković Aleksandra Đuranović Srđan Tomanović Nada Drulović Jelena |
| author_sort | Alempijević Tamara |
| collection | DOAJ |
| description | Introduction. Primary biliary cirrhosis (PBC) is an immunemediated chronic
progressive inflammatory liver disease leading to destruction of small
interlobular bile ducts. Sarcoidosis is a chronic disorder of unknown
etiology characterized by non-caseous granulomas. Case report. We reported a
69-year-old female patient with abdominal pain, malaise, vertigo, headaches,
hands tremor and partial loss of hearing. Initial laboratory findings
revealed elevated liver function tests and cholesterol with positive
antimytochondrial and antinuclear antibodies. Liver biopsy revealed granuloma
typical for PBC and granulomatous lesions typical for sarcoidosis. Elevated
serum angiotensin-converting enzyme and granulomatous lesion on the brain
magnetic resonance imaging (MRI) were detected and the patient was diagnosed
with overlap of PBC and liver sarcoidosis and neurosarcoidosis. The patient
was treated with ursodeoxicholic acid (UDCA) and prednisolone. Six months
later the patient was symptom-free with laboratory findings within normal
range. Conclusion. In PBC patients it is important to consider coexisting
granulomatous liver diseases if elevated liver function tests persist despite
UDCA therapy. |
| first_indexed | 2024-12-12T01:02:41Z |
| format | Article |
| id | doaj.art-813f7a1d9b434b388d2672f4eee5f8da |
| institution | Directory Open Access Journal |
| issn | 0042-8450 |
| language | English |
| last_indexed | 2024-12-12T01:02:41Z |
| publishDate | 2014-01-01 |
| publisher | Military Health Department, Ministry of Defance, Serbia |
| record_format | Article |
| series | Vojnosanitetski Pregled |
| spelling | doaj.art-813f7a1d9b434b388d2672f4eee5f8da2022-12-22T00:43:40ZengMilitary Health Department, Ministry of Defance, SerbiaVojnosanitetski Pregled0042-84502014-01-01711838610.2298/VSP1401083A0042-84501401083APrimary biliary cirrhosis and hepatic sarcoidosis: A case reportAlempijević Tamara0Sokić-Milutinović Aleksandra1Tončev Ljubiša2Pavlović-Marković Aleksandra3Đuranović Srđan4Tomanović Nada5Drulović Jelena6Clinical Center of Serbia, Clinic for Gastroenterology and Hepatology, Belgrade + Faculty of Medicine, BelgradeClinical Center of Serbia, Clinic for Gastroenterology and Hepatology, Belgrade + Faculty of Medicine, BelgradeClinical Center of Serbia, Clinic for Gastroenterology and Hepatology, BelgradeClinical Center of Serbia, Clinic for Gastroenterology and Hepatology, Belgrade + Faculty of Medicine, BelgradeClinical Center of Serbia, Clinic for Gastroenterology and Hepatology, Belgrade + Faculty of Medicine, BelgradeFaculty of Medicine, BelgradeFaculty of Medicine, Belgrade + Clinical Center of Serbia, Clinic for Neurology, BelgradeIntroduction. Primary biliary cirrhosis (PBC) is an immunemediated chronic progressive inflammatory liver disease leading to destruction of small interlobular bile ducts. Sarcoidosis is a chronic disorder of unknown etiology characterized by non-caseous granulomas. Case report. We reported a 69-year-old female patient with abdominal pain, malaise, vertigo, headaches, hands tremor and partial loss of hearing. Initial laboratory findings revealed elevated liver function tests and cholesterol with positive antimytochondrial and antinuclear antibodies. Liver biopsy revealed granuloma typical for PBC and granulomatous lesions typical for sarcoidosis. Elevated serum angiotensin-converting enzyme and granulomatous lesion on the brain magnetic resonance imaging (MRI) were detected and the patient was diagnosed with overlap of PBC and liver sarcoidosis and neurosarcoidosis. The patient was treated with ursodeoxicholic acid (UDCA) and prednisolone. Six months later the patient was symptom-free with laboratory findings within normal range. Conclusion. In PBC patients it is important to consider coexisting granulomatous liver diseases if elevated liver function tests persist despite UDCA therapy.http://www.doiserbia.nb.rs/img/doi/0042-8450/2014/0042-84501401083A.pdfliver cirrhosis, biliarysarcoidosisdiagnosis, differentialhistological techniquestreatment outcome |
| spellingShingle | Alempijević Tamara Sokić-Milutinović Aleksandra Tončev Ljubiša Pavlović-Marković Aleksandra Đuranović Srđan Tomanović Nada Drulović Jelena Primary biliary cirrhosis and hepatic sarcoidosis: A case report Vojnosanitetski Pregled liver cirrhosis, biliary sarcoidosis diagnosis, differential histological techniques treatment outcome |
| title | Primary biliary cirrhosis and hepatic sarcoidosis: A case report |
| title_full | Primary biliary cirrhosis and hepatic sarcoidosis: A case report |
| title_fullStr | Primary biliary cirrhosis and hepatic sarcoidosis: A case report |
| title_full_unstemmed | Primary biliary cirrhosis and hepatic sarcoidosis: A case report |
| title_short | Primary biliary cirrhosis and hepatic sarcoidosis: A case report |
| title_sort | primary biliary cirrhosis and hepatic sarcoidosis a case report |
| topic | liver cirrhosis, biliary sarcoidosis diagnosis, differential histological techniques treatment outcome |
| url | http://www.doiserbia.nb.rs/img/doi/0042-8450/2014/0042-84501401083A.pdf |
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